Category: 1904-24-1

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1904-24-1, name is 3-Amino-5-ethylpyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C5H9N3

Method 65; 4- (5-Ethvl-lH-pyrazol-3-vlamino)-2-chloropyrimidine A mixture of 2, 4-dichloropyrimidine (2.97g, 20mmol), 5-amino-3-ethyl-1H-pyrazole (2.44g, 22mmol) and N, N-diisopropylethylamine (3. 8ml, 22mmol) in dry THF (75ml) was heated at 60C for 18 hours. The volatiles were removed by evaporation, and the residue was triturated with a mixture of DCM and water. The solid product was collected by filtration, washed with water and ether, and dried to give the title compound (1.55g, 35%) as a colourless crystalline solid. NMR (DMSO): 1.20 (t, 3H), 2.60 (q, 2H), 6.06 (s, 1H), 7.15 (s, 1H), 8.10 (d, 1H), 9.80 (s, 1H), 11.83 (br s, 1H); m/z 224 [MH] +.

The synthetic route of 1904-24-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2005/40159; (2005); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Electric Literature of 1904-24-1,Some common heterocyclic compound, 1904-24-1, name is 3-Amino-5-ethylpyrazole, molecular formula is C5H9N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Method 79; 6-Ethyl-2-chloro-4- (5-ethyl-lH-pvrazol-3-ylamino) pyrimidine 2,4-Dichloro-6-ethyl-pyrimidine (J. Am. Chem. Soc. 1936, 58, 78) (1.33g 7.53mmol) was stirred in ethanol (50ml) and 5-ethyl-lH-3-amino-pyrazole (Method 6 of WO 03/048133) (0. 836g, 7.53mmol) was added followed by sodium carbonate (1.25g) and the mixture stirred at 40C for 4 days then at 55C overnight. The insoluble inorganics were removed by filtration and solvent removed from the filtrate by evaporation. Water (100ml) was added and the mixture extracted with EtOAc (3 x 50ml). The extracts were combined and washed with water (50ml), brine (50ml), dried (MgS04) and solvent removed by evaporation. The residue was purified by column chromatography on silica gel eluting with hexane/EtOAc (100: 0 increasing in polarity to 0: 100) to give the title compound (210mg, 11%) a white solid. NMR (DMSO-d6 at 100C) : 1.20 (m, 6H), 2.50-2. 70 (m, 4H), 6.05 (s, 1H), 7.05 (br s, 1H), 9.70 (br s, 1H), 11.85 (br s, 1H) ; m/z 252 [MH] +.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Amino-5-ethylpyrazole, its application will become more common.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2005/40159; (2005); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1904-24-1 as follows. Safety of 3-Amino-5-ethylpyrazole

A. 4-(2,4-dichlorophenyl)-7-ethyl-2-methyl-pyrazolo[1,5-a]-1,3,5-triazine A mixture of 3-amino-5-ethylpyrazole (10.3 g, 39.3 mmol) and N-(1-(methylthio)ethylidene)-2,4-dichloro-benzamide (4.0 g, 35.7 mmol) in anhydrous dioxan (20 mL) was stirred at reflux temperatrue under a nitrogen atmosphere for 16 h. After being cooled to ambient temperature, the reaction mix was concentrated in vacuo and the residue was treated with dichloromethane. The resulting supsension was filtered and the filtrate was concentrated in vacuo to afford an oil (1.5 g, 14% yield): NMR (CDCl3, 300 MHz): delta 7.62 (d, 1H, J=8), 7.59 (d, 1H, J=2), 7.45 (dd, 1H, J=8,2), 6.42 (s, 1H), 2.82 (q, 2H, J=8), 2.73 (s, 3H), 1.30 (t, 3H, J=8).

According to the analysis of related databases, 1904-24-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Gilligan, Paul J.; Wilde, Richard G.; US2002/147338; (2002); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics