Category: 90253-21-7

Adding a certain compound to certain chemical reactions, such as: 90253-21-7, name is 4-Cyclopropyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 90253-21-7, HPLC of Formula: C6H8N2

To a 20 ml vial, compound 211 I-135 (25.0 mg, 0.084 mmol) and 195 copper iodide (1.607 mg, 8.44 mumol) were added followed by 213 4-cyclopropyl-1H-pyrazole (9.13 mg, 0.084 mmol) and 196 trans-N,N?-dimethylcyclohexane-1,2-diamine (2.401 mg, 0.017 mmol). This mixture was then evacuated and backfilled with nitrogen (3 times). Then dry, degassed 214 1,2-dioxane (338 mul) was added. The mixture was heated at 110 C. for 24 h and cooled to RT. The crude material was purified by mass-directed reversed phase chromatography (ACN/water gradient with 0.1% 19 TFA modifier) to afford the 215 title compound. MS (ESI) [M+H]+: m/z 324. 1H NMR (600 MHz, DMSO-d6) delta 8.22 (s, 1H), 7.70 (d, J=8.4 Hz, 2H), 7.59 (q, J=6.1, 5.5 Hz, 1H), 7.51 (d, J=18.9 Hz, 1H), 7.39 (d, J=8.4 Hz, 2H), 2.96 (p, J=7.0 Hz, 2H), 2.77-2.62 (m, 2H), 2.33 (dq, J=19.2, 10.1, 9.3 Hz, 2H), 1.86-1.68 (m, 3H), 1.32 (p, J=7.1 Hz, 2H), 0.86 (t, J=6.2 Hz, 2H), 0.70 (t, J=7.3 Hz, 3H), 0.58 (d, J=4.0 Hz, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Cyclopropyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Merck Sharp & Dohme Corp.; Han, Yongxin; Achab, Abdelghani; Deng, Yongqi; Fradera, Xavier; Gibeau, Craig; Hopkins, Brett A.; Li, Derun; Liu, Kun; McGowan, Meredeth A.; Sciammetta, Nunzio; Sloman, David; White, Catherine; Zhang, Hongjun; Zhou, Hua; US2019/144433; (2019); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 90253-21-7, name is 4-Cyclopropyl-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., name: 4-Cyclopropyl-1H-pyrazole

Preparation 23b: {3-[4-(4-cyclopropylpyrazol-1 -yl)benzyl]-4-difluoromethoxy-2-ethyl- 8-fluoroquinolin-5-yloxy}acetic acid methyl ester; A mixture of (4-{[4-difluoromethoxy-2-ethyl-8-fluoro-5-(2-methoxy-2-oxoethoxy) quinolin-3-yl]methyl}phenyl)boronic acid (0.1 g), 4-cyclopropyl-1 H-pyrazole (0.047 g), cuprous acetate (0.078 g) and pyridine (3 ml_) was heated at 40 0C for 24 hours. The mixture was cooled to room temperature, diluted with water (10 mL) and extracted with ethyl acetate. The combined extracts were washed with saturated aqueous sodium chloride solution, dried over magnesium sulphate and then concentrated under reduced pressure. Purification of the residue by column chromatography on silica gel, eluting with a mixture of cyclohexane and ethyl acetate (1 :0 to 7:3 by volume) gave title compound as pale green oil (0.09 g).MS: ESI (+ve) (Method B): 526 (M+H)+, Retention time 4.5 min

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 90253-21-7.

Reference:
Patent; ARGENTA DISCOVERY LIMITED; WO2008/122784; (2008); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 90253-21-7, name is 4-Cyclopropyl-1H-pyrazole, A new synthetic method of this compound is introduced below., name: 4-Cyclopropyl-1H-pyrazole

A mixture of 3-iodo-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine (Example 18, step 1, 163 mg, 0.54 mmol), 4-cyclopropyl-1H-pyrazole (116 mg, 1.1 mmol), K2CO3(s) (149 mg, 1.1 mmol), copper (I) iodide (21 mg, 0.11 mmol), and (1R,2R)-N1,N2-dimethylcyclohexane-1,2- diamine (43 muL, 0.27 mmol) in DMF (5.38 mL) was sparged with Ar(g) and stirred at 110C until completion as determined by chromatographic (TLC or LC) monitoring. The resulting mixture was purified with silica chromatography (0 to 20% MeOH in DCM) to afford the title compound (115 mg, 75.5%). MS (apci) m/z = 284.1 [M+H].

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; ARRAY BIOPHARMA INC.; BLAKE, James F.; DAI, Donghua; HAAS, Julia; JIANG, Yutong; KOLAKOWSKI,, Gabrielle R.; METCALF, Andrew T.; MORENO, David A.; PRIGARO, Brett; REN, Li; (330 pag.)WO2019/143991; (2019); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics