Synthetic Route of 3273-44-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3273-44-7, name is 5-Methyl-1H-pyrazole-3-carbaldehyde belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
Step 1: tert-Butyl 3-formyl-5-methyl-lH-pyrazole-l-carboxylate 5-Methyl-lH-pyrazole-3-carbaldehyde (5.4 g, 49 mmol) was dissolved in acetonitrile (200 mL) and cooled to 0 C with stirring. DMAP (0.60 g, 4.9 mmol) and di-tert-butyldicarbonate (12.9 g, 59.q mmol) were added and the solution was allowed to warm to rt and stir for 16 h. The reaction was diluted with EtOAc (200 mL). Then the mixture was washed with IN HC1 (aq.) (2xl00mL), saturated aq NaHC03 (2xl00mL), dried over magnesium sulfate, filtered and concentrated. The residue was purified on silica gel to give tert-butyl 3-formyl-5-methyl-lH-pyrazole-l-carboxylate (3.9 g, 38%) as a clear oil. ‘H NMR (CDC13) delta 10.10 (s, 1H), 6.65 (s, 1H), 2.60 (s, 3H), 1.72 (s, 9H).
The synthetic route of 5-Methyl-1H-pyrazole-3-carbaldehyde has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MILLENNIUM PHARMACEUTICALS, INC.; DUFFEY, Matthew, O.; ENGLAND, Dylan, B.; HU, Zhigen; ITO, Mitsuhiro; LANGSTON, Steven, P.; MCINTYRE, Charles; MIZUTANI, Hirotake; XU, He; WO2015/2994; (2015); A2;,
Pyrazole – Wikipedia,
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