1239726-11-4 | pyrazoles-derivatives

Application of 1239726-11-4,Some common heterocyclic compound, 1239726-11-4, name is 1-(2-Fluorophenyl)-5-methoxy-1H-pyrazole-3-carboxylic acid, molecular formula is C11H9FN2O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Synthesis example 9Ethyl (S)-3-{[1 -(2-fluoro-phenyl)-5-methoxy-1 H-pyrazole-3-carbonyl]-amino}-3-(2- methyl-phenyl)-propionate Step 1 : 1 -(2-Fluoro-phenyl)-5-methoxy-1 H-pyrazole-3-carbonyl chlorideA suspension of 1 -(2-fluoro-phenyl)-5-methoxy-1 H-pyrazole-3-carboxylic acid (39.1 g, 167 mmol) in 2-methyltetrahydrofuran (300 ml) was cooled to 0 C and DMF (293 muIota, 3.81 mmol) was added. Oxalyl chloride (23.1 g, 182 mmol) was added dropwise. After 16 h at room temperature ca. 100 ml of the solvent were removed by distillation. The resulting suspension of the title compound was used directly in the next step.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-(2-Fluorophenyl)-5-methoxy-1H-pyrazole-3-carboxylic acid, its application will become more common.

Reference:
Patent; SANOFI; RUF, Sven; PERNERSTORFER, Josef; SADOWSKI, Thorsten; HORSTICK, Georg; SCHREUDER, Herman; BUNING, Christian; OLPP, Thomas; SCHEIPER, Bodo; WIRTH, Klaus; WO2011/92187; (2011); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Electric Literature of 1239726-11-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1239726-11-4, name is 1-(2-Fluorophenyl)-5-methoxy-1H-pyrazole-3-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows.

Synthesis example 174-Bromo-1 -(2-fluoro-phenyl)-5-methoxy-1 H-pyrazole-3-carboxylic acid 50 mg (0.21 mmol) of 1 -(2-fluoro-phenyl)-5-methoxy-1 H-pyrazole-3-carboxylic acid were dissolved in 1 .5 ml of acetic acid, sodium acetate (35 mg, 0.42 mmol) and bromine (50 mg, 0.21 mmol) were added and the mixture was stirred for 60 min. The solvent was removed in vacuo and the residue subjected to an aqueous work-up. The obtained crude title compound (60 mg) was used in the next step without further purification.

The chemical industry reduces the impact on the environment during synthesis 1-(2-Fluorophenyl)-5-methoxy-1H-pyrazole-3-carboxylic acid. I believe this compound will play a more active role in future production and life.

Category: 1239726-11-4

Discovery of 1-(2-Fluorophenyl)-5-methoxy-1H-pyrazole-3-carboxylic acid

Analyzing the synthesis route of 1239726-11-4