Category: 143426-49-7

Related Products of 143426-49-7,Some common heterocyclic compound, 143426-49-7, name is (4-Pyrazol-1-yl-phenyl)methanol, molecular formula is C10H10N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

4-(b) tert-Butyl [tert-butoxycarbonyl(6-{(pyridin-3-ylsulfonyl)[4-(pyrazol-1-yl)benzyl]-aminomethyl}pyridin-2-yl)amino]acetate To 65 ml of a tetrahydrofuran solution containing 5.26 g (11.0 mmol) of tert-butyl (tert-butoxycarbonyl{6-[(pyridin-3-ylsulfonyl)aminomethyl]pyridin-2-yl}amino)-acetate obtained by the same manner as in Reference example 4-(a) were added 2.00 g (11.5 mmol) of 4-(pyrazol-1-yl)benzyl alcohol (see European Journal of Medicinal Chemistry, 219, 27 (1992)), 4.0 ml (16 mmol) of tri-n-butylphosphine and 2.84 g (16.5 mmol) of N,N,N’,N’-tetramethylazodicarboxamide, and the mixture was stirred at room temperature for 16 hours. After completion of the reaction, water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with a saturated sodium chloride solution, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The obtained residue was applied to silica gel column chromatography (eluent; n-hexane:ethyl acetate=1:2 (V/V)), and the fractions containing the objective material were concentrated under reduced pressure to obtain 6.57 g of the title compound as white foam. (Yield: 94%) Mass spectrum (FAB, m/z): 635 (M++1). 1H-NMR spectrum (CDCl3, delta ppm): 8.95 (dd, J=2.3, 0.7 Hz, 1H), 8.71 (dd, J=4.9, 1.6 Hz, 1H), 7.91 (dd, J=2.5, 0.6 Hz, 1H), 7.87 (ddd, J=8.0, 2.3, 1.6 Hz, 1H), 7.72 (dd, J=1.8, 0.6 Hz, 1H), 7.71 (d, J=8.4 Hz, 1H), 7.63-7.60 (m, 2H), 7.51 (dd, J=8.4, 7.3 Hz, 1H), 7.35-7.30 (m, 3H), 6.85 (d, J=7.3 Hz, 1H), 6.47 (dd, J=2.5, 1.8 Hz, 1H), 4.61 (s, 2H), 4.39 (s, 2H), 4.35 (s, 2H), 1.53 (s, 9H), 1.42 (s, 9H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (4-Pyrazol-1-yl-phenyl)methanol, its application will become more common.

Reference:
Patent; Ube Industries, Ltd.; EP2476678; (2012); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 143426-49-7, name is (4-Pyrazol-1-yl-phenyl)methanol belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C10H10N2O

H) 1- [4- (chloromethyl) phenyl] -lH-pyrazole To a solution of [ 4- ( lH-pyrazol-l-yl ) phenyl] methanol (24.0 g) in 1 , 2-dichloroethane (200 mL) was added dropwise thionyl chloride (26.3 g) under ice-cooling, and the mixture was stirred at room temperature for 16 hr. The reaction mixture was concentrated under reduced pressure, and the residue was washed with tert-butyl methyl ether to give the title compound (23.5 g) . 1HNMR (400 MHz, CDC13) delta 4.62 (2H, s) , 6.48 (1H, t, J = 2.0 Hz), 7.47 (2H, d, J = 8.8 Hz), 7.69 (2H, d, J = 8.8 Hz), 7.73 (1H, d, J = 2.0 Hz), 7.93 (1H, d, J = 2.4 Hz).

The synthetic route of 143426-49-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; YAMADA, Masami; SUZUKI, Shinkichi; SUGIMOTO, Takahiro; NAKAMURA, Minoru; SAKAMOTO, Hiroki; KAMATA, Makoto; WO2015/163485; (2015); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 143426-49-7, name is (4-Pyrazol-1-yl-phenyl)methanol belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C10H10N2O

To a solution of l-(4-hydroxymethylphenyl)-lH-pyrazole (1.0 g, 0.005 mole) in DCM (25 mL) at 0 C under N2, was added phosphorus tribromide (0.64 mL, 0.0068 mole) drop wise. Reaction mixture was warmed to RT and stirred for 2 h. The reaction mixture was diluted with DCM (75 mL), treated with saturated aqueous sodium bicarbonate (20 mL). Organic layer was washed with water (30 mL), brine solution (30 mL) and dried over Na2S04 and concentrated under vacuum to obtain the title compound. (0227) Yield: 1.25 g; 1H – NMR (DMSO -d6, 400 MHz) d ppm: 4.76 (s, 2H), 6.55 (s, 1H), 7.56 – 7.58 (d, J = 8.5 Hz, 2H), 7.75 (s, 1H), 7.82 – 7.84 (d, J = 8.4 Hz, 2H), 8.51 – 8.52 (d, J = 2.4 Hz, 1H); Mass (m/z): 236.9 (M+H)+, 239 (M+H)+.

The synthetic route of 143426-49-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SUVEN LIFE SCIENCES LIMITED; NIROGI, Ramakrishna; SHINDE, Anil Karbhari; MOHAMMED, Abdul Rasheed; BADANGE, Rajesh Kumar; PALACHARLA, Raghava Choudary; JASTI, Venkateswarlu; (61 pag.)WO2019/102365; (2019); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Reference of 143426-49-7, A common heterocyclic compound, 143426-49-7, name is (4-Pyrazol-1-yl-phenyl)methanol, molecular formula is C10H10N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred solution of 4-(1 H-pyrazol-1 -yl)phenyl)methanol (0.2 g, 1.14 mmol) in DCM (10 mL), SOCI2 (0.2 mL, 2.29 mmol) was added at 0 C and the reaction mixture was stirred for 2 h. After completion of reaction, the reaction mixture was concentrated under vacuum and co-distilled with DCM to get the title compound. It was used in the next step without further purification. Yield: (0.170 g, brown gummy solid). LCMS: (Method A) 193.1 (M+H), Rt. 3.46 min, 94.32% (Max).

The synthetic route of 143426-49-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASCENEURON S. A.; QUATTROPANI, Anna; WISHART, Grant; KULKARNI, Santosh S.; RAKESH, Paul; (338 pag.)WO2020/39027; (2020); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Electric Literature of 143426-49-7, A common heterocyclic compound, 143426-49-7, name is (4-Pyrazol-1-yl-phenyl)methanol, molecular formula is C10H10N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 4 N-[1-(6-{[4-(1H-pyrazol-1-yl)benzyl]oxy}-1-benzofuran-3-yl)ethyl]acetamide To a solution of N-[1-(6-hydroxy-1-benzofuran-3-yl)ethyl]acetamide (35.0 mg, 0.160 mmol) obtained in Reference Example 4 in THF (5 mL) were added [4-(1H-pyrazol-1-yl)phenyl]methanol (41.8 mg, 0.240 mmol), triphenylphosphine (63.0 mg, 0.240 mmol) and 2.2 M diethyl azodicarboxylate toluene solution (0.110 mL, 0.240 mmol), and the mixture was stirred at room temperature for 30 min. The solvent was evaporated under reduced pressure and the obtained residue was purified by preparative HPLC to give the title compound (29.4 mg, yield 33%) as a white solid. preparation system: Waters large scale preparation system (UV Purification System)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Takeda Pharmaceutical Company Limited; EP2351743; (2011); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Reference of 143426-49-7,Some common heterocyclic compound, 143426-49-7, name is (4-Pyrazol-1-yl-phenyl)methanol, molecular formula is C10H10N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a suspension of (4-(1H-pyrazol-1-yl)phenyl)methanol (22.5 g) in acetonitrile (500 mL) was added N-fluoro-N’-(chloromethyl)triethylenediamine bis(tetrafluoroborate) (108 g) at room temperature, and the mixture was stirred at 80C for 16 hr. The reaction solution was diluted with ethyl acetate, washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated. The residue was purified by silica gel chromatography (petroleum ether-ethyl acetate) to give the title compound (4.5 g). 1H NMR (400 MHz, CDCl3) delta 4.73 (2H, s), 7.45 (2H, d, J = 8.0 Hz), 7.57 (1H, d, J = 4.0 Hz), 7.61 (2H, d, J = 8.0 Hz), 7.80 (1H, d, J = 4.8 Hz).

The synthetic route of 143426-49-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Takeda Pharmaceutical Company Limited; SUGIMOTO, Takahiro; NAKAMURA, Minoru; SAKAMOTO, Hiroki; SUZUKI, Shinkichi; YAMADA, Masami; KAMATA, Makoto; KOJIMA, Takuto; FUJIMORI, Ikuo; SHIMOKAWA, Kenichiro; EP2921480; (2015); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Electric Literature of 143426-49-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 143426-49-7, name is (4-Pyrazol-1-yl-phenyl)methanol belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a stirred solution of 4-(1 H-pyrazol-1 -yl)phenyl)methanol (0.2 g, 1.14 mmol) in DCM (10 mL), SOCI2 (0.2 mL, 2.29 mmol) was added at 0 C and the reaction mixture was stirred for 2 h. After completion of reaction, the reaction mixture was concentrated under vacuum and co-distilled with DCM to get the title compound. It was used in the next step without further purification. Yield: (0.170 g, brown gummy solid). LCMS: (Method A) 193.1 (M+H), Rt. 3.46 min, 94.32% (Max).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (4-Pyrazol-1-yl-phenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ASCENEURON S. A.; QUATTROPANI, Anna; WISHART, Grant; KULKARNI, Santosh S.; RAKESH, Paul; (338 pag.)WO2020/39027; (2020); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics