Category: 938066-17-2

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 938066-17-2, name is 4-Iodo-1-(tetrahydropyran-2-yl)-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., Safety of 4-Iodo-1-(tetrahydropyran-2-yl)-1H-pyrazole

lodopyrazole (153 g, 550 mmol, 1.1 equiv.) was dissolved in THF (2 L) under N2 and the solution was cooled in an ice-water bath. i-PrMgC1 (2 M in THF, 300 mL, 600 mmol,1.2 equiv.) was added dropwise with vigorous stirring. After 60 minutes, solid benzoxazinonesubstrate was added, and the ice bath was removed. After 45 minutes, 10% aqueous NaOH (720mL, 2 mol, 4 equiv.) was added, and the mixture was heated to 65 C. After five hours, thereaction mixture was cooled to room temperature, quenched with 10% aqueous HC1 (690 mL, 2 mol, 4 equiv.), and extracted with EtOAc. The combined organic extracts were dried and concentrated to afford a viscous yellow/orange oil that was used without further purification.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 938066-17-2.

Reference:
Patent; ARCUS BIOSCIENCES, INC.; LELETI, Manmohan, Reddy; MILES, Dillon, Harding; POWERS, Jay, Patrick; ROSEN, Brandon, Reid; SHARIF, Ehesan, Ul; THOMAS-TRAN, Rhiannon; (154 pag.)WO2018/204661; (2018); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 938066-17-2, name is 4-Iodo-1-(tetrahydropyran-2-yl)-1H-pyrazole, A new synthetic method of this compound is introduced below., COA of Formula: C8H11IN2O

(2) 27.8 g of the intermediate 4-bromo-1- (tetrahydro-2H-pyran-2-yl) -1H-pyrazole obtained in (1) was dissolved in 200 ml of THF,Cool to minus 75 degrees,48 ml (0.12 mol) of n-butyl lithium solution with a concentration of 2.5 mol / L was added dropwise,Maintain the temperature around minus 75 degrees,After dropping, keep warm for half an hour,Subsequently, 8.8 g (0.12 mol) of N, N-dimethylformamide is added at this temperature, and the reaction formula of step (2) is as follows:After the reaction is completed, naturally warm to room temperature,Add dilute hydrochloric acid to quench until the system pH is less than 1, stir at room temperature for 3-4 hours, neutralize with sodium bicarbonate, and extract with ethyl acetate.After drying and concentration, it was purified by silica gel short column adsorption to obtain the target product 4-formylpyrazole 7.2 g.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Changsha Luxing Biological Technology Co., Ltd.; Tan Yongjun; Yang Bing; Zhu Zhiping; Zhang Jianhua; (10 pag.)CN110734401; (2020); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics