Category: 29004-73-7

In 2018,Wuji Huaxue Xuebao included an article by Li, Song; Gan, Xian-xue; Tang, Liang-fu. Quality Control of (3-methyl-1H-pyrazol-5-yl)methanol. The article was titled 《Syntheses and catalytic properties of metal carbonyl derivatives with hydroxymethyl functionalized pyrazoles》. The information in the text is summarized as follows:

Reaction of tungsten or molybdenum carbonyl with 3(5)-hydroxymethyl-5(3)-methylpyrazole (L1), 4-hydroxymethylpyrazole (L2) and bis(3-hydroxymethyl-5-methylpyrazol-1-yl)methane (L3) yielded complexes LW(CO)5 (L = L1 or L2) and L3M(CO)4 (M = Mo or W), resp. These complexes have been fully characterized by NMR, IR and x-ray crystal structural analyses, indicating that they form 1D or 2D organometallic supramol. architectures through O-H···O, N-H···O and O-H···OC-M hydrogen bonding interactions, and these structures are significantly affected by the relative position of the hydroxymethyl group on the pyrazole ring. In addition, these complexes show moderate catalytic activity for the cyclotrimerization reaction of phenylacetylene. The experimental part of the paper was very detailed, including the reaction process of (3-methyl-1H-pyrazol-5-yl)methanol(cas: 29004-73-7Quality Control of (3-methyl-1H-pyrazol-5-yl)methanol)

(3-methyl-1H-pyrazol-5-yl)methanol(cas: 29004-73-7) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Quality Control of (3-methyl-1H-pyrazol-5-yl)methanol

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

The author of 《A new synthesis of azolooxazines》 were Lupo, B.; Tarrago, G.. And the article was published in Synthetic Communications in 1982. COA of Formula: C5H8N2O The author mentioned the following in the article:

Pyrazolooxazine derivative I was prepared from 3(5)-hydroxymethyl-5(3)-methylpyrazole (II) in two steps. II was heated with propargyl bromide in DMF to yield a mixture of III (R = CH2OH, R1 = Me) and III (R = Me, R1 = CH2OH) (IV). A mixture of IV, Bu4N+ Br-, and NaOH in C6H6 was stirred 4 h at 60° to give I. In the experiment, the researchers used many compounds, for example, (3-methyl-1H-pyrazol-5-yl)methanol(cas: 29004-73-7COA of Formula: C5H8N2O)

(3-methyl-1H-pyrazol-5-yl)methanol(cas: 29004-73-7) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. COA of Formula: C5H8N2O

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

HPLC of Formula: 29004-73-7On March 31, 2020, Wu, Yumeng; Tang, Chengrun; Rui, Ruomei; Yang, Liumeng; Ding, Wei; Wang, Jiangyuan; Li, Yiming; Lai, Christopher C.; Wang, Yueping; Luo, Ronghua; Xiao, Weilie; Zhang, Hongbing; Zheng, Yongtang; He, Yanping published an article in Acta Pharmaceutica Sinica B. The article was 《Synthesis and biological evaluation of a series of 2-(((5-akly/aryl-1H-pyrazol-3-yl)methyl)thio)-5-alkyl-6-(cyclohexylmethyl)-pyrimidin-4(3H)-ones as potential HIV-1 inhibitors》. The article mentions the following:

A series of 2-(((5-akly/aryl-1H-pyrazol-3-yl)methyl)thio)-5-alkyl-6-(cyclohexylmethyl)-pyrimidin-4(3H)-ones I [R1 = H, Me, Ph, etc.; R2 = H, Me, Et; X = H, Cl] were synthesized and their anti-HIV-1 activities were evaluated. Most of these compounds were highly active against wild-type (WT) HIV-1 strain (IIIB) with EC50 values in the range of 0.0038-0.4759μmol/L. Among those compounds,I [R1 = 4-hydroxyphenyl, R2 = Et, X = H (II)] had an EC50 value of 3.8 nmol/L and SI (selectivity index) of up to 25,468 indicating excellent activity against WT HIV-1. In vitro anti-HIV-1 activity and resistance profile studies suggested that compounds (II) and I [R1 = 4-(methylsulfanyl)phenyl, R2 = Et, X = H (III)] displayed potential anti-HIV-1 activity against laboratory adapted strains and primary isolated strains including different subtypes and tropism strains (EC50s range from 4.3 to 63.6 nmol/L and 18.9-219.3 nmol/L, resp.). On the other hand, it was observed that those two compounds (II) and (III) were less effective with EC50 values of 2.77 and 4.87μmol/L for HIV-1A17 (K103N + Y181C). The activity against reverse transcriptase (RT) was also evaluated for those compounds Both (II) and (III) obtained sub-micromolar IC50 values showed their potential in RT inhibition. The pharmacokinetics examination in rats indicated that compound (II) has acceptable pharmacokinetic properties and bioavailability. Preliminary structure-activity relationships and mol. modeling studies were also discussed. In the experiment, the researchers used (3-methyl-1H-pyrazol-5-yl)methanol(cas: 29004-73-7HPLC of Formula: 29004-73-7)

(3-methyl-1H-pyrazol-5-yl)methanol(cas: 29004-73-7) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.HPLC of Formula: 29004-73-7

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

HPLC of Formula: 29004-73-7On March 31, 2020, Wu, Yumeng; Tang, Chengrun; Rui, Ruomei; Yang, Liumeng; Ding, Wei; Wang, Jiangyuan; Li, Yiming; Lai, Christopher C.; Wang, Yueping; Luo, Ronghua; Xiao, Weilie; Zhang, Hongbing; Zheng, Yongtang; He, Yanping published an article in Acta Pharmaceutica Sinica B. The article was 《Synthesis and biological evaluation of a series of 2-(((5-akly/aryl-1H-pyrazol-3-yl)methyl)thio)-5-alkyl-6-(cyclohexylmethyl)-pyrimidin-4(3H)-ones as potential HIV-1 inhibitors》. The article mentions the following:

A series of 2-(((5-akly/aryl-1H-pyrazol-3-yl)methyl)thio)-5-alkyl-6-(cyclohexylmethyl)-pyrimidin-4(3H)-ones I [R1 = H, Me, Ph, etc.; R2 = H, Me, Et; X = H, Cl] were synthesized and their anti-HIV-1 activities were evaluated. Most of these compounds were highly active against wild-type (WT) HIV-1 strain (IIIB) with EC50 values in the range of 0.0038-0.4759μmol/L. Among those compounds,I [R1 = 4-hydroxyphenyl, R2 = Et, X = H (II)] had an EC50 value of 3.8 nmol/L and SI (selectivity index) of up to 25,468 indicating excellent activity against WT HIV-1. In vitro anti-HIV-1 activity and resistance profile studies suggested that compounds (II) and I [R1 = 4-(methylsulfanyl)phenyl, R2 = Et, X = H (III)] displayed potential anti-HIV-1 activity against laboratory adapted strains and primary isolated strains including different subtypes and tropism strains (EC50s range from 4.3 to 63.6 nmol/L and 18.9-219.3 nmol/L, resp.). On the other hand, it was observed that those two compounds (II) and (III) were less effective with EC50 values of 2.77 and 4.87μmol/L for HIV-1A17 (K103N + Y181C). The activity against reverse transcriptase (RT) was also evaluated for those compounds Both (II) and (III) obtained sub-micromolar IC50 values showed their potential in RT inhibition. The pharmacokinetics examination in rats indicated that compound (II) has acceptable pharmacokinetic properties and bioavailability. Preliminary structure-activity relationships and mol. modeling studies were also discussed. In the experiment, the researchers used (3-methyl-1H-pyrazol-5-yl)methanol(cas: 29004-73-7HPLC of Formula: 29004-73-7)

(3-methyl-1H-pyrazol-5-yl)methanol(cas: 29004-73-7) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.HPLC of Formula: 29004-73-7

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 1972,Acta Pharmaceutica Suecica included an article by Carlson, Lars A.; Hedbom, Christina; Helgstrand, Erik; Sjoberg, Berndt; Stjernstrom, Nils E.. Synthetic Route of C5H8N2O. The article was titled 《Potential hypolipidemic agents. III. Heterocyclic compounds affecting free fatty acid mobilization in vivo》. The information in the text is summarized as follows:

Compounds such as 3-methyl-5-isoxazolecarboxylic acid [4857-42-5], 5-fluoronicotinic acid [402-66-4], 5-fluoro-3-pyridylacetic acid [38129-24-7], and 3-methylpyrazole [1453-58-3] exhibited the highest inhibition of free fatty acid mobilization in blood among 188 heterocyclic compounds tested in dogs, while compounds such as 5-methyl-3-isoxazolecarboxylic acid [3405-77-4], 2-fluoronicotinic acid [393-55-5], and 3-aminobenzoic acid [99-05-8] had no effect on free fatty acid mobilization. In the experiment, the researchers used (3-methyl-1H-pyrazol-5-yl)methanol(cas: 29004-73-7Synthetic Route of C5H8N2O)

(3-methyl-1H-pyrazol-5-yl)methanol(cas: 29004-73-7) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Synthetic Route of C5H8N2O

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

The author of 《3-Methyl-5-carboxamidopyrazole, a long-lasting inhibitor of lipolysis》 were Bizzi, Adalgisa; Codegoni, A. M.; Garattini, Silvio. And the article was published in Farmaco, Edizione Scientifica in 1967. Related Products of 29004-73-7 The author mentioned the following in the article:

Nineteen 3-methyl-5-carboxypyrazole (I) derivatives were tested orally in rats for their capacity to lower plasma free fatty acids. Esterification or the reduction of the carboxy radical did not affect the properties of I; the presence of N1-substituted Me or benzyl reduced the lipolytic effect. 3-Methyl-5-carboxamidopyrazole (II) was the longest lasting compound II prevented and counteracted the increased deposition of liver triglycerides induced by ACTH (200 I.U./kg., given s.c.) or 50% EtOH (16 ml./kg.) and it reduced the plasma ketone body concentration in fasted animals. 16 references. After reading the article, we found that the author used (3-methyl-1H-pyrazol-5-yl)methanol(cas: 29004-73-7Related Products of 29004-73-7)

(3-methyl-1H-pyrazol-5-yl)methanol(cas: 29004-73-7) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Related Products of 29004-73-7

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Waszkowycz, Bohdan; Smith, Kate M.; McGonagle, Alison E.; Jordan, Allan M.; Acton, Ben; Fairweather, Emma E.; Griffiths, Louise A.; Hamilton, Niall M.; Hamilton, Nicola S.; Hitchin, James R.; Hutton, Colin P.; James, Dominic I.; Jones, Clifford D.; Jones, Stuart; Mould, Daniel P.; Small, Helen F.; Stowell, Alexandra I. J.; Tucker, Julie A.; Waddell, Ian D.; Ogilvie, Donald J. published their research in Journal of Medicinal Chemistry on December 13 ,2018. The article was titled 《Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides》.Synthetic Route of C5H8N2O The article contains the following contents:

DNA damage repair enzymes are promising targets in the development of new therapeutic agents for a wide range of cancers and potentially other diseases. The enzyme poly(ADP-ribose) glycohydrolase (PARG) plays a pivotal role in the regulation of DNA repair mechanisms; however, the lack of potent drug-like inhibitors for use in cellular and in vivo models has limited the investigation of its potential as a novel therapeutic target. Using the crystal structure of human PARG in complex with the weakly active and cytotoxic anthraquinone 8a, novel quinazolinedione sulfonamides PARG inhibitors have been identified by means of structure-based virtual screening and library design. 1-Oxetan-3-ylmethyl derivatives 33d and 35d were selected for preliminary investigations in vivo. X-ray crystal structures help rationalize the observed structure-activity relationships of these novel inhibitors. After reading the article, we found that the author used (3-methyl-1H-pyrazol-5-yl)methanol(cas: 29004-73-7Synthetic Route of C5H8N2O)

(3-methyl-1H-pyrazol-5-yl)methanol(cas: 29004-73-7) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Synthetic Route of C5H8N2O

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Grotjahn, Douglas B.; Van, Sang; Combs, David; Lev, Daniel A.; Schneider, Christian; Rideout, Marc; Meyer, Christoph; Hernandez, Genaro; Mejorado, Lupe published their research in Journal of Organic Chemistry on December 27 ,2002. The article was titled 《New Flexible Synthesis of Pyrazoles with Different, Functionalized Substituents at C3 and C5》.Recommanded Product: 29004-73-7 The article contains the following contents:

Pyrazoles functionalized at the 3 and 5 positions without carbon substituents at nitrogen are prepared in short sequences from THP-protected 3-propyn-1-ol and 4-propyn-1-ol. Lithiation of protected alkynes THPO(CH2)nCCH (n = 1,2) followed by transmetalation with zinc chloride and addition of acid chlorides RCOCl (R = Me, Me2CH, Me3C, Ph) provides alkynones THPO(CH2)nCCCOR; the alkynones are also prepared by palladium-catalyzed coupling reactions of protected alkynols and acid chlorides RCOCl (R = Me2CH, Me3C, Ph, 1-adamantyl)in triethylamine. Exothermic addition of hydrazine hydrate to alkynones THPO(CH2)nCCCOR (n = 1,2; R = Me, Me2CH, Me3C, Ph, 1-adamantyl) provides pyrazoles I (n = 1,2; R = Me, Me2CH, Me3C, Ph, 1-adamantyl; R1 = THPO); acid deprotection followed by chlorination with thionyl chloride provides pyrazolealkyl chlorides I (n = 1,2; R = Me, Me2CH, Me3C, Ph, 1-adamantyl; R1 = Cl). Substitution of I with lithium diphenylphosphide or thiolate salts generated in situ provides I (n = 1,2; R = Me, Me2CH, Me3C, Ph, 1-adamantyl; R1 = Ph2P, MeS, PhS, HOCH2CH2S, Me3CS) with potential use as neutral monodentate ligands. Compounds such as I (n = 1; R = Me3C; R1 = Cl) have been prepared in 2 d on a 30 g scale in 71% overall yield. In the experiment, the researchers used many compounds, for example, (3-methyl-1H-pyrazol-5-yl)methanol(cas: 29004-73-7Recommanded Product: 29004-73-7)

(3-methyl-1H-pyrazol-5-yl)methanol(cas: 29004-73-7) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Recommanded Product: 29004-73-7

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

The author of 《Inhibition of fatty acid release by pyrazole derivatives》 were Bizzi, Adalgisa. And the article was published in Progress in Biochemical Pharmacology in 1968. Recommanded Product: (3-methyl-1H-pyrazol-5-yl)methanol The author mentioned the following in the article:

In rats, 3,5-dimethylpyrazole (I) is quiet active in decreasing free fatty acid (FFA) and glycerol in adipose tissue as well as in plasma with doses as low as 50 μg/kg, i.p. In plasma after 2 hr, I and 5-carboxyl-3-methylpyrazole (II) appear more active than 3-methylpyrazole. When tested in vitro on the release of FFA from adipose tissue, II appeared to be the most active. The 3 compounds when given orally in doses of 0.75-30 mg/kg also produce up to a 50% decrease in plasma triglycerides. This effect is proportional to the dose used. The experimental part of the paper was very detailed, including the reaction process of (3-methyl-1H-pyrazol-5-yl)methanol(cas: 29004-73-7Recommanded Product: (3-methyl-1H-pyrazol-5-yl)methanol)

(3-methyl-1H-pyrazol-5-yl)methanol(cas: 29004-73-7) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Recommanded Product: (3-methyl-1H-pyrazol-5-yl)methanol

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

《Inhibition of the acid corrosion of iron with new pyrazole derivatives》 was written by Aouniti, A.; Hammouti, B.; Brighli, M.; Kertit, S.; Berhili, F.; El-Kadiri, S.; Ramdani, A.. Application of 29004-73-7 And the article was included in Journal de Chimie Physique et de Physico-Chimie Biologique on August 31 ,1996. The article conveys some information:

Some new synthesized pyrazole organic-type compounds have been tested as inhibitors for the corrosion of iron in 1M HCl by weight-loss and electrochem. polarization methods. Both technique gave the same order of inhibition. The compound 1,3-bis(3′-chloromethyl-5′-methyl-1′-pyrazolyl)propane (Inh.9) was the best inhibitor and its inhibition efficiency increased with increasing concentration, reaching 95% at 4.10-4M. Polarization measurements have shown that the pyrazole substances studied inhibited both the anodic reaction of iron dissolution and the cathodic reaction of hydrogen evolution. These products act without changing the mechanism of the cathodic hydrogen evolution reaction. The corrosion inhibition of pyrazole studied is regarded by a simple blocked fraction of the electrode surface related to adsorption of inhibitor species according to Langmuir isotherm model on the iron surface. The introduction in the pyrazole ring of a substitute such as -OH, -CO2H, -CO2CH3, and -Cl in the position 3, enhances the inhibiting effect of the pyrazole compounds The effect of temperature on the corrosion behavior of iron indicated that inhibition efficiencies of (Inh. 9) increased with increasing temperature in the range of 25-50°C. The apparent activation energy for iron corrosion process are modified by addition of (Inh. 9). In addition to this study using (3-methyl-1H-pyrazol-5-yl)methanol, there are many other studies that have used (3-methyl-1H-pyrazol-5-yl)methanol(cas: 29004-73-7Application of 29004-73-7) was used in this study.

(3-methyl-1H-pyrazol-5-yl)methanol(cas: 29004-73-7) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Application of 29004-73-7

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics