In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 179057-10-4, name is Methyl 4-(1H-pyrazol-5-yl)benzoate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Product Details of 179057-10-4
Example 168: 1-(4-Benzoyl-2-methyl-piperazin-1-V-)-2-r4-(2H-pyraz?l-3- yl)-phen yli-etha?e-1.2-dio?e; To a solution of 4-(2/-/-pyrazol-3-yl)-benzoic acid methyl ether (0.2 g, 1 mmol) and (4-benzoyl-2-methyl-piperazin-1-yl)-acetonitrile (0.24 g, 1 mmol) in anhydrous THF (2 mL) was added by drops 1.06 M solution LiHMDS in THF (4 mL, 4 mmol). The reaction mixture was stirred for 1 hour, and m-CPBA was added (0.67 g, 4 mmol). The mixture was stirred for 1 hour additionally, quenched with water, extracted with EtOAc, dried over sodium sulfate, filtered and evaporated. The residue was purified by SiO2 chromatography using 10% MeOH/ethyl acetate as eluent to obtain 1-(4-benzoyl-2-methyl-piperazin-1-yl)- 2-[4-(2H-pyrazol-3-yl)-phenyl]-ethane-1,2-dione (0.09 g, 22%). LCMS: CaICd for C23H22N4O3 ? H+: m/z = 403.5. Found: m/z = 403, 404. 1H NMR (DMSO- d6): 13.59 and 13.16 (two br s, 1H, NH-pyrazole); 8.06 (m, 2H); 7.95-7.86 (m, 3H); 7.45-7.40 (m, 5H); 6.89 (br s, 1 H); 4.68-4.30 (br signal, 2 H); 3.29-3.43
The synthetic route of 179057-10-4 has been constantly updated, and we look forward to future research findings.