Category: 51516-68-8

Some common heterocyclic compound, 51516-68-8, name is 5-Amino-1-(3-chlorophenyl)-1H-pyrazole-4-carbonitrile, molecular formula is C10H7ClN4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 5-Amino-1-(3-chlorophenyl)-1H-pyrazole-4-carbonitrile

General procedure: 5-amino-1-aryl-1H-pyrazole-4-carbonitriles 4(aei) (0.001 mol),2.0 mL of 1,2-diaminoethane (ethylenediamine) and carbon disulfide(0.004 mol) were added into a 50 mL round-bottom flaskadapted with a glass condenser. The mixture was kept at 110-115oCfor 12-14 hours. After that, the productwas poured into cold water,the precipitate was filtered out and washed with cold water. Thereactions were accompanied by means of TLC and dichloromethaneas eluent.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 51516-68-8, its application will become more common.

Reference:
Article; Monteiro; Lechuga; Lara; Souto; Vigano; Bourguignon; Calvet; Oliveira; Alves; Souza-Silva; Santos; Pereira; European Journal of Medicinal Chemistry; vol. 182; (2019);,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 51516-68-8, name is 5-Amino-1-(3-chlorophenyl)-1H-pyrazole-4-carbonitrile, This compound has unique chemical properties. The synthetic route is as follows., Formula: C10H7ClN4

Title compound 2A, 5-amino-1-(3-chloro-phenyl)-1H pyrazole-4-carbonitrile (0.2 g, 0.91 mmol) was suspended in formamide (10 ml). The suspension was heated to 210C for 1 hour then allowed to cool to room temperature. To the reaction mixture was added water (10 ml), the resultant precipitate was collected by filtration, washed with water (2 x 10 ml) and dried on the filter. The crude solid was then purified by column chromatography with ethyl acetate/heptane (1: 1) as the eluent to give the title compound as a white solid (68 mg, 0.278 mmol, 30%). LC-MS: [M+H]+=246, Rt = 1.06 min, 98% purity.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 51516-68-8.

Reference:
Patent; DeveloGen Aktiengesellschaft; Evotec AG; EP1746099; (2007); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Electric Literature of 51516-68-8,Some common heterocyclic compound, 51516-68-8, name is 5-Amino-1-(3-chlorophenyl)-1H-pyrazole-4-carbonitrile, molecular formula is C10H7ClN4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The experimental procedure was similar to synthesis of analogs1(aei). 5-amino-1-aryl-1H-pyrazole-4-carbonitriles 4(aei)(0.001 mol) were reacted with 2.0 mL of 1,3-diaminopropane andcarbon disulfide (0.004 mol). The temperaturewas 85-95oC and thereaction time was 14-16 hours. The reaction mixture was pouredinto cold water, the precipitate was filtered out and washed withcold water. The reactions were accompanied by means of TLC anddichloromethane as eluent.

The synthetic route of 51516-68-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Monteiro; Lechuga; Lara; Souto; Vigano; Bourguignon; Calvet; Oliveira; Alves; Souza-Silva; Santos; Pereira; European Journal of Medicinal Chemistry; vol. 182; (2019);,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Reference of 51516-68-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 51516-68-8, name is 5-Amino-1-(3-chlorophenyl)-1H-pyrazole-4-carbonitrile, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: 5-Amino-1-aryl-1H-pyrazole-4-carbonitriles 1a-j (10 mmol) and SnCl4 (2.3 mL, 20 mmol) were added to a stirred solution of acetylacetone (10 mmol) in dry toluene (20 mL). The reaction mixture was stirred under nitrogen at room temperature for 30 min and then heated under reflux for 5-6 h. The reaction mixture was cooled and poured into water and titrated to pH 12-13 with a saturated aqueous solution of Na2CO3. After filtration, the filtrate was extracted three times with ethyl acetate and the organic layer was dried and evaporated at reduced pressure to give the solid product. The product was purified by silica gel column chromatography and eluted with ethyl acetate/petroleum (1:3, v:v) to give 3a-h and 4a-j.

The chemical industry reduces the impact on the environment during synthesis 5-Amino-1-(3-chlorophenyl)-1H-pyrazole-4-carbonitrile. I believe this compound will play a more active role in future production and life.