Category: 51395-52-9

Pathak, Sudipta et al. published their research in RSC Advances in 2014 | CAS: 51395-52-9

4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Formula: C4H5BrN2O

Monobromomalononitrile: an efficient regioselective mono brominating agent towards active methylene compounds and enamines under mild conditions was written by Pathak, Sudipta;Kundu, Ashis;Pramanik, Animesh. And the article was included in RSC Advances in 2014.Formula: C4H5BrN2O This article mentions the following:

The potential of monobromomalononitrile (MBM) as a convenient source of cationic bromine in organic bromination reaction was explored. Studies reveal that MBM could be a good substitute for N-bromosuccinimide (NBS) in various respects. Enamines and active methylene compounds bearing aromatic rings were selectively mono brominated on the vinylic and active methylene group resp. on reaction with MBM. This methodol. had the advantages of easy preparation of MBM, shorter reaction time and high yields of the product formation and is environment friendly. Mono bromination reaction occurred only on active methylene groups even after addition of excess amount of MBM. Enamines containing electron withdrawing, electron donating and ortho substituted amines reacted smoothly affording only the vinylic mono bromo products in good yields without producing any side products. In the experiment, the researchers used many compounds, for example, 4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9Formula: C4H5BrN2O).

4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Formula: C4H5BrN2O

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Bischoff, Christian et al. published their research in Journal fuer Praktische Chemie/Chemiker-Zeitung in 1994 | CAS: 51395-52-9

4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.Computed Properties of C4H5BrN2O

Oxidation of pyrazolinones was written by Bischoff, Christian;Ramm, Matthias;Schroeder, Edith;Jancke, Harald. And the article was included in Journal fuer Praktische Chemie/Chemiker-Zeitung in 1994.Computed Properties of C4H5BrN2O This article mentions the following:

Oxidation of pyrazolinones I (R = H, Ph, CONH2) with H2O2/HCOOH gave dimer II which underwent cleavage on treatment with either phenylhydrazine or Br2 to pyrazolinones III (Q = :NNHPh, Br, resp.). In the experiment, the researchers used many compounds, for example, 4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9Computed Properties of C4H5BrN2O).

4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.Computed Properties of C4H5BrN2O

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Devi, S. et al. published their research in Journal of the Indian Chemical Society in 1983 | CAS: 51395-52-9

4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Quality Control of 4-Bromo-3-methyl-1H-pyrazol-5(4H)-one

Synthesis and fungitoxicity of derivatives of thiopyrazolone and their oxidation products was written by Devi, S.;Mitra, P.;Mishra, S. B.;Mittra, A. S.. And the article was included in Journal of the Indian Chemical Society in 1983.Quality Control of 4-Bromo-3-methyl-1H-pyrazol-5(4H)-one This article mentions the following:

On treatment with P2S5, pyrazolones afford thiopyrazolones which on condensation with 4-monobromo- and dibromopyrazolones in 1:1 and 1:2 ratio, resp., yield mixed bis and tris derivatives, i.e. I and II. The bis compounds of thiopyrazolone were also prepared These compounds with their oxidized derivatives were assayed for antifungal activity against Pyricularia oryzae and Helminthosporium oryzae. Some of the compounds show a very good fungicidal activity and are compared with standard com. fungicides. In the experiment, the researchers used many compounds, for example, 4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9Quality Control of 4-Bromo-3-methyl-1H-pyrazol-5(4H)-one).

4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Quality Control of 4-Bromo-3-methyl-1H-pyrazol-5(4H)-one

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Das, N. B. et al. published their research in Journal of the Indian Chemical Society in 1979 | CAS: 51395-52-9

4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Computed Properties of C4H5BrN2O

Synthesis of quinazolone and its derivatives as potential fungicides was written by Das, N. B.;Mittra, A. S.. And the article was included in Journal of the Indian Chemical Society in 1979.Computed Properties of C4H5BrN2O This article mentions the following:

Condensation of 4-bromo-2-pyrazolin-5-one with 2-mercapto-3-aryl-4-quinazolones afforded quinazolones I (R = aryl,R1 = H, Ph). They are fungitoxic against the rice blast pathogen Pyricularia oryzae and brown leaf spot pathogen Helminthosporium oryzae. In the experiment, the researchers used many compounds, for example, 4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9Computed Properties of C4H5BrN2O).

4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Computed Properties of C4H5BrN2O

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Bakavoli, Mehdi et al. published their research in Journal of Chemical Research in 2014 | CAS: 51395-52-9

4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.SDS of cas: 51395-52-9

One-pot, procedure for the preparation of some thiazino[2,3-b]quinoxaline derivatives was written by Bakavoli, Mehdi;Eshghi, Hossein;Azizollahi, Hamid;Saberi, Sattar;Bazrafshan, Faezeh. And the article was included in Journal of Chemical Research in 2014.SDS of cas: 51395-52-9 This article mentions the following:

An efficient and convenient synthesis of new thiazino[2,3-b]quinoxaline derivatives I (R = CH3, C6H5, 4-MeC6H4, etc.) has been developed by employing a one-pot cyclocondensation of several α-haloketones and 3-aminoquinoxaline-2-thiol in acetic acid. A similar reaction with 4-bromo-3-methyl-4,5-dihydro-1H-5-pyrazolone gave a new heterocyclic system, 3-methyl-1,4-dihydropyrazolo[4′,3′:5,6][1,4]thiazino[2,3-b]quinoxaline. In the experiment, the researchers used many compounds, for example, 4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9SDS of cas: 51395-52-9).

4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.SDS of cas: 51395-52-9

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Chande, Madhukar S. et al. published their research in Indian Journal of Chemistry in 2000 | CAS: 51395-52-9

4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.Product Details of 51395-52-9

Synthesis of new heterocycles by using thiocarbohydrazide and thiosemicarbazides was written by Chande, Madhukar S.;Pankhi, Mohd Aslam;Ambhaikar, Shireesh B.. And the article was included in Indian Journal of Chemistry in 2000.Product Details of 51395-52-9 This article mentions the following:

3-Amino-2-alkyl/arylimino-5-carbethoxy-thiazolidin-4-ones, 2-hydrazino-6-carbethoxy-4H,6H-1,3,4-thiadiazin-5-one, 2-hydrazino-7-substituted, 5,7-disubstituted-4H-pyrazolo[5,4-e]1,3,4-thiadiazines and 2-hydrazino-7-phenyl-4H-isoxazolo[5,4-e]-1,3,4-thiadiazine have been synthesized. The compounds have been characterized by chem. reactions, alternate syntheses and spectral data. In the experiment, the researchers used many compounds, for example, 4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9Product Details of 51395-52-9).

4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.Product Details of 51395-52-9

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Brief introduction of 51395-52-9

The synthetic route of 51395-52-9 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 51395-52-9,Some common heterocyclic compound, 51395-52-9, name is 4-Bromo-3-methyl-1H-pyrazol-5(4H)-one, molecular formula is C4H5BrN2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of 2-amino-3-quinoxalinethiol (0.177 g, 1 mmol) and the appropriate alpha-haloketones (1 mmol) in glacial acetic acid (10 mL) was heated under reflux for the appropriate time. The solvent was evaporated under reduced pressure and the precipitate was collected and recrystallised from ethanol.

The synthetic route of 51395-52-9 has been constantly updated, and we look forward to future research findings.