Category: 1151814-36-6

Synthetic Route of 1151814-36-6,Some common heterocyclic compound, 1151814-36-6, name is 1-Cyclopropyl-1H-pyrazole, molecular formula is C6H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

step 1 1-cyclopropyl-4-iodo -1H- pyrazole-pyrazole 100 mg, cyclopropyl boronic acid 253 mg, sodium carbonate 312 mg 1,2-dichloroethane in addition to 2.5 ml, was added dropwise 1,2-dichloroethane 5ml with copper acetate 267mg and 2,2-bipyridine 230mg was suspended and stirred for 4 hours at 70 C..After dilution with ethyl acetate, saturated aqueous ammonium chloride solution, washed successively with water and saturated brine, and dried over magnesium sulfate.Under reduced pressure, after the evaporation of the solvent gave 148mg as a yellow oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Cyclopropyl-1H-pyrazole, its application will become more common.

Reference:
Patent; NIPPON SHINYAKU COMPANY LIMITED; FUJIHARA, HIDETAKA; ASAKI, TETSUO; HORI, KATSUTOSHI; NAITO, HARUNA; (146 pag.)JP5668756; (2015); B2;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 1151814-36-6, name is 1-Cyclopropyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1151814-36-6, category: pyrazoles-derivatives

To a solution of crude 1 -cyclopropyl- lH-pyrazole (108 mg, 1.00 mmol) in CEtaCI3 (4 mL) at room temperature was added Br2 (51 uL, 1.0 mmol) via syringe. The orange solution was stirred for 1 h. The reaction was diluted with saturated aqueous Na2S2O3 (3 mL) and saturated aqueous NaHCO3 (3 mL). The mixture was extracted with CH2Cl2 (3 x 5 mL). The combined organic layers were dried over Na2Stheta4 and concentrated on a rotary evaporator without heating the sample to give 4-bromo-l -cyclopropyl- lH-pyrazole as a volatile, light yellow liquid that was used without further purification, m/z 187.3 [M + H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Cyclopropyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; LEMIEUX, Rene, Marc; BRUNETTE, Steven, Richard; HORAN, Joshua, Courtney; KOWALSKI, Jennifer, A.; LAWLOR, Michael, David; MCKIBBEN, Bryan; MILLER, Craig, Andrew; BARBOSA, Antonio, J.M.; WO2010/141273; (2010); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 1151814-36-6, name is 1-Cyclopropyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1151814-36-6, Computed Properties of C6H8N2

To a solution of crude 1 -cyclopropyl- lH-pyrazole (108 mg, 1.00 mmol) in CEtaCI3 (4 mL) at room temperature was added Br2 (51 uL, 1.0 mmol) via syringe. The orange solution was stirred for 1 h. The reaction was diluted with saturated aqueous Na2S2O3 (3 mL) and saturated aqueous NaHCO3 (3 mL). The mixture was extracted with CH2Cl2 (3 x 5 mL). The combined organic layers were dried over Na2Stheta4 and concentrated on a rotary evaporator without heating the sample to give 4-bromo-l -cyclopropyl- lH-pyrazole as a volatile, light yellow liquid that was used without further purification, m/z 187.3 [M + H]+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.