Category: 153912-60-8

Reference of 153912-60-8, These common heterocyclic compound, 153912-60-8, name is 1,5-Dimethyl-1H-pyrazol-3-yl-methanol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[5-Cyano-7-(1,5-dimethyl-1H-pyrazol-3-ylmethoxy)-8-methyl-1-propyl-1,3,4,9-tetrahydro pyrano[3,4-b]indol-1-yl]-acetic acid To a solution of 5-cyano-7-hydroxy-8-methyl-1-propyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indol-1-yl)-acetic acid methyl ester (50 mg, 0.15 mmoles) in DCM (1 mL) was added (1,5-dimethyl-1H-pyrazol-3-yl)-methanol (20 mg, 0.17 mmoles) and triphenylphosphine (95 mg, 0.37 mmol). To this was added 1,1′-(azodicarbonyl)dipiperidine (ADDP, 92 mg, 0.37 mmoles). The reaction was stirred for 1.5 hours, diluted with EtOAc and washed twice with H2O and brine. The EtOAc layer was dried (MgSO4) and concentrated. Flash chromatography on SiO2 eluding with 1:1 hexane/EtOAc yielded 53 mg (80%) of a yellow oil that crystallized upon standing.

Statistics shows that 1,5-Dimethyl-1H-pyrazol-3-yl-methanol is playing an increasingly important role. we look forward to future research findings about 153912-60-8.

Reference:
Patent; Condon, Stephen M.; Jackson, Randy William; Laporte, Matthew G.; Burns, Christopher J.; Herbertz, Torsten; Gaboury, Janet A.; US2007/219212; (2007); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Related Products of 153912-60-8, The chemical industry reduces the impact on the environment during synthesis 153912-60-8, name is 1,5-Dimethyl-1H-pyrazol-3-yl-methanol, I believe this compound will play a more active role in future production and life.

To a solution of (1 ,5-dimethyl-i H-pyrazol-3-yl)methanol (250 mg, 1.98 mmol) in CH2CI2 (15 mL) was added MesCI (0.16 mL, 2.08 mmol) and TEA (0.83 mL, 5.95 mmol). The reaction mixture was stirred at RT overnight, concentrated and the product used in the next step without further purification.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,5-Dimethyl-1H-pyrazol-3-yl-methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NOVARTIS AG; ALTMANN, Eva; HOMMEL, Ulrich; LORTHIOIS, Edwige, Liliane, Jeanne; MAIBAUM, Juergen, Klaus; OSTERMANN, Nils; QUANCARD, Jean; RANDL, Stefan, Andreas; VULPETTI, Anna; WO2014/2054; (2014); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 153912-60-8, name is 1,5-Dimethyl-1H-pyrazol-3-yl-methanol, A new synthetic method of this compound is introduced below., Formula: C6H10N2O

Preparation of 3-(chloromethyl)-l,5-dimethyl-lH-pyrazole hydrochloride: To (l,5-dimethyl-lH-pyrazol-3-yl)methanol (5.01 g, 39.71 mmol) in DCM (80 mL) at 0 C was cautiously added thionyl chloride (25 mL, 343.6 mmol). The cold bath was removed and the reaction mixture was stirred at ambient temperature for 3 hours. The reaction mixture was concentrated under reduced pressure to give crude product (7.32 g).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.