Category: 70500-80-0

Ramalingam, Tamilarasan’s team published research in Journal of Heterocyclic Chemistry in 2017 | CAS: 70500-80-0

Ethyl 5-amino-1-methyl-1H-pyrazole-3-carboxylate(cas: 70500-80-0) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Application In Synthesis of Ethyl 5-amino-1-methyl-1H-pyrazole-3-carboxylate

《A Facile and Solvent-Free Silica-Supported Route for the Preparation of Pyrazolium Salts and Its Catalytic Responses》 was published in Journal of Heterocyclic Chemistry in 2017. These research results belong to Ramalingam, Tamilarasan; Kilivelu, Ganesan. Application In Synthesis of Ethyl 5-amino-1-methyl-1H-pyrazole-3-carboxylate The article mentions the following:

Synthesis of di/trimeric substituted pyrazolium salts, e.g., I was carried out under a conventional/solvent-free silica-supported muffle furnace method. The solid phase method observed remarkable response compared with the conventional method for the preparation of pyrazolium salts. Di/trimeric substituted pyrazolium salts were acted as a very good catalyst for diaryl glycolic acid RC6H4C(OH)(COOH)(C6H4R) (R = H, 2-NO2, 3-MeO, 4-OH) preparation while compared with existing literatures. In addition to this study using Ethyl 5-amino-1-methyl-1H-pyrazole-3-carboxylate, there are many other studies that have used Ethyl 5-amino-1-methyl-1H-pyrazole-3-carboxylate(cas: 70500-80-0Application In Synthesis of Ethyl 5-amino-1-methyl-1H-pyrazole-3-carboxylate) was used in this study.

Ethyl 5-amino-1-methyl-1H-pyrazole-3-carboxylate(cas: 70500-80-0) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Application In Synthesis of Ethyl 5-amino-1-methyl-1H-pyrazole-3-carboxylate

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Brief introduction of Ethyl 5-amino-1-methyl-1H-pyrazole-3-carboxylate

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 5-amino-1-methyl-1H-pyrazole-3-carboxylate, its application will become more common.

Electric Literature of 70500-80-0,Some common heterocyclic compound, 70500-80-0, name is Ethyl 5-amino-1-methyl-1H-pyrazole-3-carboxylate, molecular formula is C7H11N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 6-chloro-N-cyclopropyl-8-((4-methoxybenzyl)(methyl) amino)imidazo [1 ,2-bjpyridazine-3 -carboxamide (id) (125 mg, 0.324 mmol), ethyl 5-amino-i-methyl- 1H-pyrazole-3 -carboxylate [Free based (sodium bicarbonate solutionlEtOAc) from HC1 salt purchased from Acorn Pharma. Tech.j (88 mg, 0.5 18 mmol), Pd2(dba)3 (29.7 mg, 0.032 mmol), XANTPHOS (37.5 mg, 0.065 mmol) and Cs2CO3 (422 mg, 1.296 mmol) in DMA (2 mL) was degassed by bubbling N2 through the mixture for 5 minutes. The reaction vessel was sealed and heated to 125 C for 2 hr. After cooling to rt, the reaxtion mixture was partitioned between EtOAc (50 ml) and water (50 ml). The organic layer was washed with 10%LiC1 solution (2 x 50 ml) and brine (50 ml). After drying (Na2SO4) and filtration the organic layer was concentrated toafford a tan solid that was chromatographed on a 12 gm ISCO silica gel cartridge, eluting with a 0-1 OO%EtOAc/Hex gradient. The pure fractions were concentrated to afford ethyl 5 -((3-(cyclopropylcarbamoyl)-8-((4-methoxybenzyl)(methyl)amino)imidazo [1,2- bjpyridazin-6-yl)amino)- 1-methyl-i H-pyrazole-3 -carboxylate (39a) (126 mg, 0.243 mmol, 75 % yield) as atan solid. LC retention time 2.77 mm [Cj. MS (E+) m/z: 519(MHj.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 5-amino-1-methyl-1H-pyrazole-3-carboxylate, its application will become more common.