Category: 5775-86-0

Adding a certain compound to certain chemical reactions, such as: 5775-86-0, name is 4-Bromo-1,5-dimethylpyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5775-86-0, Safety of 4-Bromo-1,5-dimethylpyrazole

To a solution of 1.5 (lg, 3.22mmol, leq) in 1,4- dioxane (7 .2mL) and water (2. 8mL) was added 4-bromo- 1,5 -dimethyl- 1 H-pyrazole (0. 780g, 4.83mmol,1.5eq),and potassium carbonate (1.27g, 9.67mmol, 3eq).The reaction mixture was degassed by argon for 30 mm. [1,1 ?-Bi sdiphenylphosphinoferrocene]palladium(II) dichloride CH2C12 complex (0.080g, 9.67mmol, 0.O3eq), was added into reaction mixture and again reaction mixture was degassed by argon for 30 mm. Further reaction mixture was stirred at 100C for 4h. Upon completion, reaction mixture transferred into water and extracted with ethyl acetate. Organic layers were combined, dried over Na2SO4 and concentrated in vacuo to obtain crude product. This was purified by column chromatography and compound was eluted in 20% ethyl acetate in hexane to obtain pure 631.6 (0.530g, 59.06%). MS(ES): m/z 279.37 [M+H]t

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-1,5-dimethylpyrazole, and friends who are interested can also refer to it.

Reference:
Patent; NIMBUS LAKSHMI, INC.; GREENWOOD, Jeremy Robert; LEIT DE MORADEI, Silvana Marcel; MASSE, Craig E.; MCLEAN, Thomas H.; MONDAL, Sayan; (869 pag.)WO2018/75937; (2018); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Electric Literature of 5775-86-0, The chemical industry reduces the impact on the environment during synthesis 5775-86-0, name is 4-Bromo-1,5-dimethylpyrazole, I believe this compound will play a more active role in future production and life.

To compound 264.4(5.Og, l6mmol, 1.Oeq) and 4- bromo-1,5-dimethyl-1H-pyrazole (2.74g, l4mmol, 0.84eq) in 1,4-dioxane (4OmL), potassium carbonate (6.96g, 48mmol, 3.Oeq) was added. Argon gas was purged through the reaction for 10- 1 5mm. Then, [1,1 ?-Bis(diphenylphosphino)ferrocene]dichloropalladium(II)] complex with CH2C12 (0.41g, 0.48mmol, 0.O3eq) was added. Reaction mixture was stirred at 100-110 C for 3h. After completion of the reaction, the reaction mixture was transferred to water and extracted with ethyl acetate. Organic layers were combined, dried over anhydrous Na2SO4, filtered and evaporated under vacuum to obtain 264.5 (1.5g, 33.6%). MS(ES): m/z 266.37 [M+H]t

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-1,5-dimethylpyrazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NIMBUS LAKSHMI, INC.; GREENWOOD, Jeremy Robert; LEIT DE MORADEI, Silvana Marcel; MASSE, Craig E.; MCLEAN, Thomas H.; MONDAL, Sayan; (869 pag.)WO2018/75937; (2018); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application of 5775-86-0, These common heterocyclic compound, 5775-86-0, name is 4-Bromo-1,5-dimethylpyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of tert-butyl (3S)-3-[[4-[1-(benzenesulfonyl)-6-(4,4,5,5-tetramethyl]-1,3,2-dioxaborolan-2-yl)indol-3-yl]-5-(trifluoromethyl)pyrimidin-2-yl]amino]piperidine-1-carboxylate (120.00 mg, 164.93 umol) and 4-bromo-1,5-dimethyl-pyrazole (31.75 mg, 181.42 umol) in dioxane (5 mL) and H2O (500 uL) was added Pd(PPh3)4 (19.06 mg, 16.49 umol) and Cs2CO3 (107.47 mg, 329.85 umol). The mixture was stirred at 100 C for 4 h under N2. The mixture was poured into water (100 mL). The aqueous phase was extracted with EA (50 mL*3). The combined organic phase was washed with brine (100 mL), dried with anhydrous Na2SO4, filtered and concentrated. The residue was purified by column chromatography (SiO2, Petroleum ether/ethyl acetate=5/1 to 2:1) to give to afford the title compound (150 mg, crude).

Statistics shows that 4-Bromo-1,5-dimethylpyrazole is playing an increasingly important role. we look forward to future research findings about 5775-86-0.