Category: 18213-75-7

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 18213-75-7, name is 5-Amino-1-methyl-1H-pyrazole-4-carboxamide, A new synthetic method of this compound is introduced below., Formula: C5H8N4O

The mixture of 5-amino-1-methyl-1H-pyrazole-4-carboxamide (70 g, 0.49 mol), EtONa (117 g, 1.72 mol) and the intermediate from Step B ( (272 g, 1.16 mol) in EtOH (1 L) was stirred in a sealed bottle at 120C overnight. The mixture was concentrated and the residue was diluted with H2O (2 L) and then adjusted to pH = 6 with 2 N aqueous HC1 solution. The mixture was extracted with EtOAc (1 L x 3). The combined organic layer was dried over Na2SO4, filtered and concentrated. The residue was purified by silica gel column chromatography using petroleum ether/EtOAc = 1 : 1 to give the title product.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; MERCK SHARP & DOHME CORP.; HAN, Xiaoqing; WHITEHEAD, Alan; RAGHAVAN, Subharekha; CERNAK, Timothy, A.; DREHER, Spencer; GROEPER, Jonathan; GUO, Jian; ZHANG, Yong; WO2015/88886; (2015); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Related Products of 18213-75-7, A common heterocyclic compound, 18213-75-7, name is 5-Amino-1-methyl-1H-pyrazole-4-carboxamide, molecular formula is C5H8N4O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

5-Amino-I-methyl-I H-pyrazole-4-carboxylic acid amide (1.49 g; 10.618 mmol and 4,4-dimethyl-dihydro-pyran-2,6-dione (2.26 g; 15.898 mmol) was heatedto 170 C for 6 h. The reaction mixture was cooled to room temperature, 10% aqueous sodium hydroxide solution (56.00 mL) was added and the mixture was heated to 100 C for 2h. The reaction mixture was cooled to 0 C, acidified with acetic acid and extracted with dichloromethane. The combinedorganic layers were dried with sodium sulfate, filtered by suction and concentrated. The residue was triturated with petrol ether and ethyl acetate (1/I), the resulting solid was filtered and dried. Yield: 0.80 g (28%) colorless solid: LC/MS (B), Rt: 1.84 mm; (M+H) 265.0. ?H NMR (400 MHz, DMSO-d6) 6 13.00 (brs, IH), 12.12 (brs, IH), 7.92 (s, IH), 3.86 (s, 3H), 2.68 (5, 2H), 2.22(s, 2H), 1.04 (s, 6H)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; MERCK PATENT GMBH; BUCHSTALLER, Hans-Peter; DORSCH, Dieter; (111 pag.)WO2017/76484; (2017); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 18213-75-7, name is 5-Amino-1-methyl-1H-pyrazole-4-carboxamide, A new synthetic method of this compound is introduced below., SDS of cas: 18213-75-7

To 5 -amino- 1 -methyl- lH-pyrazole-4-carboxamide (2 g, 14.3 mmol) and sodium 2,2-difluoro-2-(5-fluoropyridin-2-yl)acetate (3.64 g, 17.12 mmol) was added trimethylsilyl polyphosphate (20 mL) and the mixture was heated at 130 C overnight. The solution was cooled, equal volumes of EtOAc and water were added, and the mixture was stirred for 30 min. The organic layer was washed with brine, separated, dried over Na2S04, filtered, and concentrated under reduced pressure. The residue was dissolved in DCM and extracted with 1 N aqueous NaOH. The aqueous layer was washed with DCM and then acidified with 4 N HC1 and extracted with EtOAc. The organic layer was separated, dried over Na2S04, filtered, and concentrated under reduced pressure to afford 6-(difluoro(5-fluoropyridin-2- yl)methyl)-l -methyl- lH-pyrazolo[3,4-d]pyrimidin-4-ol (1.85 g, 44%) as a solid, which was used without further purification. H NMR (300 MHz, DMSO-t 6) delta 11.67 (s, 1H), 8.77 (s, 1H), 7.95 – 8.21 (m, 3H), 3.74 (s, 3H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Application of 18213-75-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 18213-75-7, name is 5-Amino-1-methyl-1H-pyrazole-4-carboxamide belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Diphosgene (50 mmol) was dissolved in 1 ,4-dioxane (150 mL) and 3g (21 mmol) of 3 was added; the reaction mixture was heated to 80 0C and stirred at this temperature for 12 hours, then cooled and concentrated under reduced pressure. The white precipitate was filtered and washed with ether. The yield was 2.1 g, 62 %. 1H NMR DMSO-d6 delta, ppm: 3.80 s (3H), 7.76 s (1 H)1 10.80 s (1H), 12.0 s (1 H).

The synthetic route of 5-Amino-1-methyl-1H-pyrazole-4-carboxamide has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 18213-75-7 as follows. Computed Properties of C5H8N4O

Example 1.2.: 1-methyl-1H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione (3) 7 g (50 mmol) of 5-amino-1-methyl-1H-pyrazole-4-carboxamide (2) is mixed with an excess of urea (50 g) and the mixture is heated at 200C for 3 h. The reaction cake is cooled to RT and the residue is dissolved in 500 mL of chloroform. The organic phase is washed with 5% aqueous acetic acid. The organic phase is separated and the solvent is evaporated. The title compound is purified by crystallization from water.

According to the analysis of related databases, 18213-75-7, the application of this compound in the production field has become more and more popular.