Category: 89179-62-4

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 89179-62-4, name is 1-Methyl-1H-pyrazole-3-carboxamide belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 89179-62-4

To a solution of 1-methyl-1H-pyrazole-3-carboxamide (400 mg, 3.2 mmol) in dioxane (30mL) was added LAH (365 mg, 9.6 mmol). The resulting mixture was stirred for 3 h at 100°C.After it was cooled to 0°C, it was quenched with 0.4 ml water, 0.4 mL 15percent NaOH aqueous, 1.2mL water in tum. Anhydrous sodium sulfate was added to the solution. The mixture was filteredand concentrated to give the crude product which was used for the next step directly.

The synthetic route of 89179-62-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott D.; MCCOMAS, Casey C.; REGER, Thomas S.; QI, Changhe; WO2014/139150; (2014); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 89179-62-4, name is 1-Methyl-1H-pyrazole-3-carboxamide, This compound has unique chemical properties. The synthetic route is as follows., Safety of 1-Methyl-1H-pyrazole-3-carboxamide

Description 30; (1-Methvl-pvrazole-3-methanamine) A solution of Description 29 (0.08g) in anhydrous tetrahydrofuran (5ml) was treated with a 1 M solution of borane/tetrahydrofuran complex in tetrahydrofuran (3. 5mi) and the mixture was heated at 65¡ãC for 18hrs. On cooling the mixture was cautiously quenched by dropwise addition of methanol followed by 2N hydrochloric acid. The solvents were removed by evaporation, and the residue was made basic with triethylamine and concentrated in vacuo. The mixture was dissolved in a small volume of methanol applied onto a sulphonic acid SCX ion exchange cartridge (10g), eluting with methanol followed by 10percent 0. 880 ammonia in methanol. The basic fraction was evaporated in vacuo to give the title compound (0.054g) as a colourless oil which also contained-10percent of 1 H- pyrazole-3-methanamine [CAS No. 37599-58-9]. 1H nmr (D4MeOH), No. 3. 84 (2H, s, CH2) ; 3. 86 (3H, s, Me); 6.28 (1H , m, Ar); 7.53 (1H, m, Ar).

According to the analysis of related databases, 89179-62-4, the application of this compound in the production field has become more and more popular.