Category: 37687-18-6

Application of 37687-18-6, The chemical industry reduces the impact on the environment during synthesis 37687-18-6, name is 1-(1-Methyl-1h-pyrazol-4-yl)-ethanone, I believe this compound will play a more active role in future production and life.

Method 31 Synthesis of 2-bromo-1-(6-methyl-3-pyridyl)ethanone (Intermediate 45) To a solution of R-12 (10 g, 79.3 mmol) in MeCN (200 mL) at 0 C. is added N,O-dimethylhydroxylaminehydrochloride (8.5 g, 87.2 mmol), EDCI (18.2 g, 95.2 mmol), 1-hydroxybenzotriazole (3.2 g, 23.8 mmol) followed by triethylamine (20.5 mL, 158 mmol) and stirred at room temperature 15 h. The reaction mixture is partitioned between water and EtOAc. The collected organics are dried with anhydrous Na2SO4, filtered, and concentrated in vacuo to give I-43 (12 g) m/z 170.0 [M+H].

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(1-Methyl-1h-pyrazol-4-yl)-ethanone, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BARTOLOZZI, Alessandra; CHEN, Zhidong; DINES, Jonathon Alan; LO, Ho Yin; LOKE, Pui Leng; OLAGUE, Alan; RIETHER, Doris; TYE, Heather; WU, Lifen; ZINDELL, Renee M.; US2013/196967; (2013); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Reference of 37687-18-6, These common heterocyclic compound, 37687-18-6, name is 1-(1-Methyl-1h-pyrazol-4-yl)-ethanone, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

B. Synthesis of 2-bromo-1-(1-methyl-1H-pyrazol-4-yl)ethanone A solution of 1-(1-methyl-1H-pyrazol-4-yl)ethanone (28.5 g, 230 mmol) in dichloromethane (400 mL) was diluted with absolute ethanol (100 mL) and treated portion-wise with pyridinium tribromide (95%, 77.3 g, 230 mmol). The reaction was stirred at room temperature for 3 hours, during which time it solidified; the mixture was diluted with dichloromethane (300 mL) and water (400 mL), treated with sodium sulfite (5 g) and stirred for 10 minutes. The organic layer was dried over magnesium sulfate, filtered and concentrated in vacuo. The residue was washed with water (200 mL), collected by filtration, washed again with water, and dried to afford the product as an off-white solid. Yield: 41.6 g, 205 mmol, 89%. 1H NMR (500 MHz, CDCl3) delta 7.97-7.98 (m, 1H), 7.95 (br s, 1H), 4.17 (s, 2H), 3.95-3.96 (m, 3H).

Statistics shows that 1-(1-Methyl-1h-pyrazol-4-yl)-ethanone is playing an increasingly important role. we look forward to future research findings about 37687-18-6.

Reference:
Patent; Pfizer Inc.; US2012/214791; (2012); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 37687-18-6, name is 1-(1-Methyl-1h-pyrazol-4-yl)-ethanone belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C6H8N2O

General procedure: Selenium dioxide (8.0 g, 0.072 mol) was dissolved in 50 mL 1,4-dioxane by warming to 50 oC. Compound 53c (16.2 g, 0.072 mol) was added to the resulting solution, and the reaction mixture was heated under reflux for 5 h. The reaction mixture was filtered, and the filtrate was concentrated. The residue was dissolved in 100 mL DCM, triethyl orthoformate (21.5 g, 0.145 mol) and p-toluene sulfonic acid monohydrate (0.3 g, 0.002 mol) were added, and the resulting mixture was heated under reflux for 1 h and concentrated. The residue was purified by silica gel chromatography (DCM)

The synthetic route of 37687-18-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zhan, Zhengsheng; Peng, Xia; Liu, Qiufeng; Chen, Fang; Ji, Yinchun; Yao, Shanyan; Xi, Yong; Lin, Yipeng; Chen, Tiantian; Xu, Yechun; Ai, Jing; Geng, Meiyu; Duan, Wenhu; European Journal of Medicinal Chemistry; vol. 116; (2016); p. 239 – 251;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Related Products of 37687-18-6, The chemical industry reduces the impact on the environment during synthesis 37687-18-6, name is 1-(1-Methyl-1h-pyrazol-4-yl)-ethanone, I believe this compound will play a more active role in future production and life.

Method 31 Synthesis of 2-bromo-1-(6-methyl-3-pyridyl)ethanone (Intermediate 45) To a solution of R-12 (10 g, 79.3 mmol) in MeCN (200 mL) at 0 C. is added N,O-dimethylhydroxylaminehydrochloride (8.5 g, 87.2 mmol), EDCI (18.2 g, 95.2 mmol), 1-hydroxybenzotriazole (3.2 g, 23.8 mmol) followed by triethylamine (20.5 mL, 158 mmol) and stirred at room temperature 15 h. The reaction mixture is partitioned between water and EtOAc. The collected organics are dried with anhydrous Na2SO4, filtered, and concentrated in vacuo to give I-43 (12 g) m/z 170.0 [M+H].

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(1-Methyl-1h-pyrazol-4-yl)-ethanone, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BARTOLOZZI, Alessandra; CHEN, Zhidong; DINES, Jonathon Alan; LO, Ho Yin; LOKE, Pui Leng; OLAGUE, Alan; RIETHER, Doris; TYE, Heather; WU, Lifen; ZINDELL, Renee M.; US2013/196967; (2013); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

These common heterocyclic compound, 37687-18-6, name is 1-(1-Methyl-1h-pyrazol-4-yl)-ethanone, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 1-(1-Methyl-1h-pyrazol-4-yl)-ethanone

Lithium bis(trimethylsilyl)amide (1.0 M in THF, 9.5 mL, 9.5 mmol) was added to a solution of methyl 5-bromo-l-(2-trimethylsilylethoxymethyl)-l,2,4-triazole-3-carboxylate (2.0 g, 5.9 mmol) and l -(l-methylpyrazol-4-yl)ethanone (1.20 g, 9.5 mmol) in THF (40 mL) at 0C. After, the reaction was warmed to rt and stirred for 1 h. The reaction was diluted with water and isopropyl acetate. A 5% citric acid solution was added and the aqueous layer was extracted with isopropyl acetate (4 x 100 mL). The combined organic layers were dried with sodium sulfate, concentrated and the crude residue was purified by flash column chromatography (silica, 0% to 100% isopropyl acetate – heptane) to givel -[5-bromo-l -(2-trimethylsilylethoxymethyl)-l ,2,4-triazol-3-yl]-3-(l -methylpyrazol-4- yl)propane-l,3-dione (2.40 g, 5.60 mmol, 94% yield). LCMS RT = 1.57 min, m/z = 427.9 [M + H]+.

The synthetic route of 1-(1-Methyl-1h-pyrazol-4-yl)-ethanone has been constantly updated, and we look forward to future research findings.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; PATEL, Snahel; HAMILTON, Gregory; ZHAO, Guiling; CHEN, Huifen; DANIELS, Blake; STIVALA, Craig; (358 pag.)WO2019/12063; (2019); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Reference of 37687-18-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 37687-18-6 as follows.

1-(1-Methyl-1H-pyrazol-4-yl)ethanone (18 g, 145 mmol) and NBS (31 g, 174 mmol) were added to the reaction flask.Add CCl4 (80 mL) to dissolve, and add AIBN (2.4 g, 14.5 mmol) in portions under reflux, and react under 365 nm UV irradiation for 24 h.After the reaction is completed, the system is poured into ice water, extracted with dichloromethane, dried over anhydrous sodium sulfate, and the solvent is removed for column chromatography.(eluent: Petroleum ether/EtOAc (v/v) = 5/1),5.9 g of a yellow oily product were obtained in a yield: 20%.

According to the analysis of related databases, 37687-18-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Dongguan Dongyang Guang Ke Research And Development Co., Ltd.; Li Yitao; Lin Jian; Chi Weilin; Zeng Shuiming; (43 pag.)CN110294747; (2019); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Related Products of 37687-18-6, A common heterocyclic compound, 37687-18-6, name is 1-(1-Methyl-1h-pyrazol-4-yl)-ethanone, molecular formula is C6H8N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Intermediate 282-Bromo- 1 -( 1 -methyl- 1 H-pyrazol-4-vDethanoneIn a 25 mL flask, 1 -(I -methyl- lH-pyrazol-4-yl)ethanone (0.602 g, 4.85 mmol) was dissolved in chloroform (20 mL). The colorless solution was made acidic with the addition of a few drops of HBr in acetic acid (3.92 mg, 0.05 mmol). A chloroform solution containing Br2 (0.262 mL, 5.09 mmol) was added dropwise via an addition funnel. The reaction mixture was stirred at room temperature for 1 h, and then concentrated under reduced pressure. The crude solid was triturated in ethyl acetate, filtered, and dried in vacuo. The free base was obtained by triturating the product in 5% NaHCCb for 2 h. The solid was collected by filtration, washed with water, isopropyl alcohol and then dried in vacuo. Isolation gave 874 mg of the title compound.LC/MS (ES+)[(M+H)+]: 204 for C6H7BrN2O.1H NMR (300 MHz, d6-DMSO): 3.88 (s, 3H), 4.56 (s, 2H), 7.99 (s, IH), 8.47 (s, IH).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.