Category: 13808-62-3

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 13808-62-3 as follows. Recommanded Product: 13808-62-3

EXAMPLE 126 alpha-Bromo-N,N,4-trimethyl-3-phenylpyrazole-1-propionamide Following the procedure of Example 121, but substituting 2,3-dibromo-N,N-dimethylpropionamide for 2-bromo-N,N,2-trimethylpropionamide and 4-methyl-3-phenylpyrazole for 3-phenylpyrazole there was obtained alpha-bromo-N,N,4-trimethyl-3-phenylpyrazole-1-propionamide having a melting point of 104-107 C. Analysis: Calc’d. for C15 H18 BrN3 O: C, 53.58; H, 5.39; N, 12.50; Br, 23.77. Found: C, 53.99; H, 5.51; N, 12.63; Br, 23.43.

According to the analysis of related databases, 13808-62-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; The Upjohn Company; US4072498; (1978); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13808-62-3, name is 4-Methyl-3-phenyl-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Formula: C10H10N2

Alternative Synthesis for N,N,alpha,4-tetramethyl-3-phenylpyrazole-1-acetamide A mixture of 4-methyl-3-phenylpyrazole (3.65 g., 0.023 mole) N,N-dimethyl-2-chloropropionamide (3.78 g., 0.027 mole) and anhydrous potassium carbonate (4.4 g., 0.032 mole) was heated with stirring at 130 C. for 6 hours. The reaction mixture was cooled and crystallized from 50% aqueous methanol to give 4.5 g. of N,N,alpha,4-tetramethyl-3-phenylpyrazole-1-acetamide as large rods, m.p. 87-89 C.

The synthetic route of 13808-62-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; The Upjohn Company; US4072498; (1978); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13808-62-3, name is 4-Methyl-3-phenyl-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C10H10N2

Part A — alpha,4-Dimethyl-3-phenylpyrazole-1-acetic acid Sodium hydride (50.0 g., 57% in oil, 1.2 mole) was added over 20 minutes to a stirred solution of 4-methyl-3-phenylpyrazole (158 g., 1.0 mole) in THF (1.0 l.) maintained at 10-20 C. Ethyl 2-bromopropionate (235 g., 1.3 mole) was added and the solution stirred for 18 hours, after which time ethanol was added and the solvent was removed by evaporation at reduced pressure. The residue was treated at 90 C. with sodium hydroxide (100 g., 2.5 mole) in 800 ml. 60% aqueous methanol for 30 minutes. After cooling, the solution was extracted with ether (3 * 200 ml.), and the aqueous phase was acidified with concentrated hydrochloric acid to give 148 g. of crude alpha,4-dimethyl-3-phenylpyrazole-1-acetic acid, m.p. 151-162 C. Recrystallization from aqueous methanol gave 111 g. of product, m.p. 168-172 C. The analytical sample was recrystallized from ethyl acetate, m.p. 170-172 C. Analysis: Calc’d for C13 H14 N2 O2: C, 67.81; H, 6.13; N, 12.17. Found: C, 68.32; H, 6.14; N, 12.06.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 13808-62-3.

Reference:
Patent; The Upjohn Company; US4072498; (1978); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 13808-62-3, name is 4-Methyl-3-phenyl-1H-pyrazole, A new synthetic method of this compound is introduced below., COA of Formula: C10H10N2

General procedure: A mixture of (E)-2-methyl-3-phenylacrylaldehyde (1c) (146 mg, 1.0 mmol) and TsNHNH2 (205 mg, 1.1 mmol) in CH3CN (2 mL) were stirred at room temperature for 3 h and then CH3CN (2 mL), NaOH (44 mg, 1.1 mmol) were added and the mixture was heated at reflux for 15 h, then NaOH (60 mg, 1.5 mmol) and benzyl bromide (255 mg, 1.5 mmol) were subsequently added and the mixture was stirred at room temperature for 2 h. The product was extracted with Et2O and the organic layer was washed with brine, dried over anhydrous MgSO4, filtered, and concentrated in vacuo. Purification by chromatography on silica gel afforded the desired product 4k as colorless oil (233 mg, 94%).

The synthetic route of 13808-62-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Tang, Meng; Zhang, Fu-Min; Tetrahedron; vol. 69; 5; (2013); p. 1427 – 1433;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 13808-62-3 as follows. Quality Control of 4-Methyl-3-phenyl-1H-pyrazole

EXAMPLE 126 alpha-Bromo-N,N,4-trimethyl-3-phenylpyrazole-1-propionamide Following the procedure of Example 121, but substituting 2,3-dibromo-N,N-dimethylpropionamide for 2-bromo-N,N,2-trimethylpropionamide and 4-methyl-3-phenylpyrazole for 3-phenylpyrazole there was obtained alpha-bromo-N,N,4-trimethyl-3-phenylpyrazole-1-propionamide having a melting point of 104-107 C. Analysis: Calc’d. for C15 H18 BrN3 O: C, 53.58; H, 5.39; N, 12.50; Br, 23.77. Found: C, 53.99; H, 5.51; N, 12.63; Br, 23.43.

According to the analysis of related databases, 13808-62-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; The Upjohn Company; US4072498; (1978); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Reference of 13808-62-3,Some common heterocyclic compound, 13808-62-3, name is 4-Methyl-3-phenyl-1H-pyrazole, molecular formula is C10H10N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of (E)-2-methyl-3-phenylacrylaldehyde (1c) (146 mg, 1.0 mmol) and TsNHNH2 (205 mg, 1.1 mmol) in CH3CN (2 mL) were stirred at room temperature for 3 h and then CH3CN (2 mL), NaOH (44 mg, 1.1 mmol) were added and the mixture was heated at reflux for 15 h, then NaOH (60 mg, 1.5 mmol) and benzyl bromide (255 mg, 1.5 mmol) were subsequently added and the mixture was stirred at room temperature for 2 h. The product was extracted with Et2O and the organic layer was washed with brine, dried over anhydrous MgSO4, filtered, and concentrated in vacuo. Purification by chromatography on silica gel afforded the desired product 4k as colorless oil (233 mg, 94%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Methyl-3-phenyl-1H-pyrazole, its application will become more common.

Reference:
Article; Tang, Meng; Zhang, Fu-Min; Tetrahedron; vol. 69; 5; (2013); p. 1427 – 1433;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Electric Literature of 13808-62-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13808-62-3, name is 4-Methyl-3-phenyl-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Alternate Synthesis for alpha-ethyl-N,N,4-trimethyl-3-phenylpyrazole-1-acetamide Sodium methoxide powder (216 g., 4.0 mole) was added over 10 minutes at a stirred solution of 4-methyl-3-phenylpyrazole (632 g., 4.0 mole) in tetrahydrofuran (1.0 liter) at 10 C. 2-Bromo-N,N-dimethylbutyramide (911 g., 4.7 mole) was added dropwise over 30 minutes while maintaining the temperature of the reaction solution below 30 C. by external cooling. The solution was stirred for an additional 30 minutes at room temperature, and the THF was then removed under reduced pressure. The residual oil was partitioned between chloroform and water. The chloroform layer was evaporated and the residual oil was recrystallized from benzene:Skellysolve B to give 772 g. of alpha-ethyl-N,N,4-trimethyl-3-phenylpyrazole-1-acetamide, m.p. 85.5-87.5 C. Evaporation of the crystallization mother liquors gave 365 g. of oil containing additional product.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Methyl-3-phenyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.