Category: 66121-71-9

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 66121-71-9, name is 4-Cyano-1-methylpyrazole, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 4-Cyano-1-methylpyrazole

Step 3: 5-( 1-methyl-I H-pyrazol-4-yI)-2H-tetrazole1-mcthyl-IH-pyrazole-4-carbonitrile (18 gm, 0.168 moles) obtained instep 2, tn-nbutyl tin chloride (65 gm, 0.218 moles), sodium azide (14 gm, 0.20 Imoles) were taken in toluene (180 ml). The reaction mixture was stirred for 24 hours at 110-120C. The progress of the reaction was monitored by HPLC. The above reaction mixture was cooled to 10-15C, to this added 10% ethanolic HC1 solution (100 ml, pH= 1-2). The reaction mixture was stirred for 1-1.5 hours at 10i5C, filtered off the inorganic salts, washed with ethanol (30 ml). Themother liquor and washings were collected and toluene and ethanol were recovered at 50-55C at reduced pressure. To the abOve residue at 20-25C, added di-isopropyl ether (100ml), stirred for 1-2 hours at 20-25C, filtered the solid, washed with.di-isopropyl ether (30ml) and dried at 60-65C to yield the product, 5-(1-methyl-1H-pyrazol-4-yl)-2H-tetrazole.Drywt 25gmYield 1.4 w/w (99%)

According to the analysis of related databases, 66121-71-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; RALLIS INDIA LIMITED; PALIMKAR, Sanjay Sambhajirao; PAWAR, Jivan Dhanraj; SANKAR, B; KADAM, Subhash Rajaram; HINDUPUR, Rama Mohan; PRABHU, Venkatesh M; PATI, Hari Narayan; SUPHALA, Vadiraj Gopinath; MANE, Avinash Sheshrao; WO2014/2110; (2014); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Electric Literature of 66121-71-9, These common heterocyclic compound, 66121-71-9, name is 4-Cyano-1-methylpyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

dissolved in Et2O (30 mL) and was added, and the the solution stirred for 30 min. 1 -Methyl- lH-pyrazole-4-carbonitrile (1 g, 9.34 mmol) was added in Et2O (20 mL) at -78 0C and the reaction was allowed to warm to room temperature over 1 h, then MeOH (10 mL) containing ammonium acetate (0.720 g, 9.34 mmol) was added. The solvents were evaporated and the residue taken up in DCM and water. The organic layer was separated and the aqueous phase extracted with DCM. The combined organic phases were shaken with Brine and dried over MgSO4, filtered and the solvent evaporated to give the product (1.4 g, 68% yield): MS (ES) m/z 220 [M+l]+.

Statistics shows that 4-Cyano-1-methylpyrazole is playing an increasingly important role. we look forward to future research findings about 66121-71-9.

Electric Literature of 66121-71-9, The chemical industry reduces the impact on the environment during synthesis 66121-71-9, name is 4-Cyano-1-methylpyrazole, I believe this compound will play a more active role in future production and life.

1-Methyl-1H-pyrazole-4-carbonitrile (18 gm, 0.168 moles) obtained in step 2, tn-nbutyl tin chloride (65 gm, 0.2 18 moles), sodium azide (14 gm, 0.20lmoles) were taken in toluene (180 ml). The reaction mixture.was stirred for 24 hours at 100-120C. The progress of the reaction was monitored by HPLC. The above reaction mixture was cooled to 10- 15C, to this added 10% ethanolic HCI solution (100 ml, pH= 1-2). The reaction mixturewas stirred for 1-1.5 hours at 10-15C, filtered off the inorganic salts, washed with ethanol (30 ml). The mother liquor and washings were collected and toluene and ethanol were recovered at 50-55C at reduced pressure. To the above residue at 20-25C, added diisopropyl ether (100 ml), stirred for 1-2 hours at 20-25C, filtered the solid, washed with diisopropyl ether (30 ml) and air dried the product, 5-(1-methyl-IH-pyrazol-4-yl)-2H-tetrazole at 60-65C.Drywt25gm1.4 w/w (99%)1.40w/wYieldTheoretical yield

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Cyano-1-methylpyrazole, other downstream synthetic routes, hurry up and to see.