Category: 694-31-5

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 694-31-5 as follows. Quality Control of 1,5-Dimethyl-1H-pyrazole

N-Iodosuccinimide (35.8 g, 159 mmol) was added to a 10 C. solution of 1,5-dimethyl-1H-pyrazole (15.3 g, 159 mmol) in N,N-dimethylformamide (20 mL). The reaction mixture was stirred at 10 C. for 16 hours, and at 15 C. for 48 hours, whereupon it was diluted with ethyl acetate (500 mL) and washed sequentially with water (3*100 mL), aqueous sodium sulfite solution (100 mL), and saturated aqueous sodium chloride solution (50 mL). The organic layer was dried over sodium sulfate, filtered, and concentrated in vacuo to afford the product as a white solid. Yield: 28.0 g, 126 mmol, 79%. 1H NMR (400 MHz, CDCl3) delta 7.41 (s, 1H), 3.85 (s, 3H), 2.29 (s, 3H).

According to the analysis of related databases, 694-31-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Pfizer Inc.; Kablaoui, Natasha Mariam; Green, Michael Eric; Montgomery, Justin Ian; Brodney, Michael Aaron; Verhoest, Patrick Robert; Kauffman, Gregory Wayne; Rankic, Danica Antonia; Mente, Scot Richard; Rogers, Bruce Nelsen; Arora, Kapildev Kashmirilal; Dunn, Matthew Francis; (98 pag.)US2018/148432; (2018); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 694-31-5, name is 1,5-Dimethyl-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 1,5-Dimethyl-1H-pyrazole

General procedure: To a solution of pyrazole 1a (50.0 g, 0.45 mol) in pyridine (200 mL,2.6 mol) cooled to 0 C (CF3CO)2O (69.5 mL, 0.50 mol) was added dropwise. The mixture was stirred at r.t. for 12 h. H2O (1000 mL) was added. The formed suspension was washed with CH2Cl2 (3 × 500 mL). The organic layer was dried (Na2SO4), filtered, and evaporated under vacuum. The residue was purified by vacuum distillation (bp 107-110 C/26.7 mbar) to afford pure 2a (78.6 g, 0.38 mmol, 84%) as a yellowish liquid.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 694-31-5.

Reference:
Article; Yarmoliuk, Dmytro V.; Arkhipov, Viatcheslav V.; Stambirskyi, Maksym V.; Dmytriv, Yurii V.; Shishkin, Oleg V.; Tolmachev, Andrei A.; Mykhailiuk, Pavel K.; Synthesis; vol. 46; 9; (2014); p. 1254 – 1260;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Electric Literature of 694-31-5,Some common heterocyclic compound, 694-31-5, name is 1,5-Dimethyl-1H-pyrazole, molecular formula is C5H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In this example, the preparation of 1,5-dimethylpyrazole hydrobromide is as follows:1.442 g (15 mmol) of 1,5-dimethylpyrazole and 3.102 g (18 mmol) of hydrobromic acid were respectively added to 100 mL of three neck Bottle, stirring 15 ~ 30h; After the reaction, the addition of water, the product was washed with ethyl acetate and dried to give a white solid 1,5-dimethylpyrazole hydrobromide ionic liquid, a yield of 70%

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,5-Dimethyl-1H-pyrazole, its application will become more common.