Category: 50-33-9

Application of 50-33-9,Some common heterocyclic compound, 50-33-9, name is Phenylbutazone, molecular formula is C19H20N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

3-((2R,3R)-1-(Dimethylamino)-2-methylpentan-3-yl)phenol (250 mg) was dissolved while heating in as little ethanol as possible. 4-Butyl-1 ,2-diphenylpyrazolidine-3,5- dione (Phenylbutazone, 339 mg) was dissolved in H2O/ethanol under heating. The solutions were mixed, heated to reflux for 12 hours and allowed to cool to room temperature overnight. The solvent was removed in vacuo and the residue was dried by freeze drying to obtain a white solid (589 mg).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Phenylbutazone, its application will become more common.

Reference:
Patent; GRUeNENTHAL GMBH; WO2007/128412; (2007); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Related Products of 50-33-9, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 50-33-9, Name is Phenylbutazone, SMILES is O=C(C1CCCC)N(C2=CC=CC=C2)N(C3=CC=CC=C3)C1=O, belongs to pyrazoles-derivatives compound. In a article, author is Moremi, Mamolatelo J., introduce new discover of the category.

The crystal structure of fac-tricarbonyl(4,4-dimethyl-2,2-dipyridyl-kappa N-2,N ‘-(pyrazole-kappa N)rhenium(I) nitrate, C18H16O3N4Re

C18H16O3N4Re, monoclinic, P2(1)/c (no. 14), a = 9.8409(6) angstrom, b = 14.0933(9) angstrom, c = 13.9153(9) angstrom, beta = 90.558(2)degrees, V = 1929.8(2) angstrom(3), Z = 4, R-gt(F) = 0.0266, wR(ref)(F-2) = 0.0584, T = 100(2) K.

Related Products of 50-33-9, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 50-33-9.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

In an article, author is Kuthyala, Sharanya, once mentioned the application of 50-33-9, Name is Phenylbutazone, molecular formula is C19H20N2O2, molecular weight is 308.37, MDL number is MFCD00005500, category is pyrazoles-derivatives. Now introduce a scientific discovery about this category, Recommanded Product: 50-33-9.

Synthesis, Characterization, and Anticancer Studies of Some Pyrazole-Based Hybrid Heteroatomics

Defined with a dual-mode of action, the hybrid molecule synthesis is an attractive strategy to endure the scientific challenges in drug discovery. Besides worthy development in cancer therapy, it is still a leading cause of death across the globe. Failure in terms of efficacy, selectivity and toxicity, the statistics of a potential drug to concrete the cancer is rather in bleak. In the present study, synthesized hybrid molecules were well characterized by spectroscopy techniques. The single-crystal X-ray crystallography study revealed the monoclinic crystal system of Dimethyl 1,4-dihydro-2,6-dimethyl-4-(3-(5-methyl-1-phenyl-1H-pyrazol-4-yl)-1H-pyrazol-4-yl)pyridine-3,5-dicarboxylate (5 b) with spacegroupC2/c. MTT assay provided the anticancer property of the compounds Diethyl1,4-dihydro-3,5-dimethyl-4-(3-(5-methyl-1-phenyl-1H-pyrazol-4-yl)-1H-pyrazol-4-yl)pyridine-2,6-dicarboxylate (5 a) and 5-methyl-1-phenyl-4-(4-(4,5-diphenyl-1H-imidazol-2-yl)-1H-pyrazol-3-yl)-1H-pyrazole (6 a) against A549 cell lines with the IC(50)values of 42.79 mu M and 55.13 mu M respectively. The AO-EB staining assay for cell death analysis confirmed the selective action of both5 aand6 a. Further, molecular docking confirmed the effective binding with cyclin-dependent kinase (CDK2) protein, suggesting that the target compounds are remarkable inhibitors in dysregulating the CDK2 protein in cancer cells.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 50-33-9, Recommanded Product: 50-33-9.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 50-33-9, Name is Phenylbutazone, SMILES is O=C(C1CCCC)N(C2=CC=CC=C2)N(C3=CC=CC=C3)C1=O, belongs to pyrazoles-derivatives compound. In a document, author is Xia, Xiao Li, introduce the new discover, Name: Phenylbutazone.

Highly sensitive ruthenium complex-based fluorescent probe for copper ion detection

A Ru(II) complex 1 ([Ru(bpy)(2)(L)](PF6)(2) (L = 2-(1H-pyrazol-5-yl)-1H-imidazo-[4,5-f] [1,10] phenanthroline, bpy = 2,2′-bipyridine)), which included adjacent imidazole and pyrazole moieties as responsive bidentate ligand, had been designed and synthesized as a ‘turn-off fluorescent probe for sensitively and selectively detecting Cu2+ in methanol and test strips. It displayed easy synthesis, large Stokes shift (178 nm) and long emission wavelength (633 nm). After addition of Cu2+, the probe 1 exhibited obvious fluorescence quenching (ca. 83%) and color change from red to dark. The detection limit of Cu2+ ions was as low as 1.78 x 10(-8) M, which was far lower than the permissible level of copper ion (similar to 20 mu M) in drinking water set by the EPA (Environmental Protection Agency). Moreover, the results of test strip experiments and real water sample detection experiments demonstrated the probe 1 possesses potential application of ions recognition in environment. (C) 2020 Published by Elsevier Ltd.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 50-33-9 is helpful to your research. Name: Phenylbutazone.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Chemistry, like all the natural sciences, Formula: C19H20N2O2, begins with the direct observation of nature¡ª in this case, of matter.50-33-9, Name is Phenylbutazone, SMILES is O=C(C1CCCC)N(C2=CC=CC=C2)N(C3=CC=CC=C3)C1=O, belongs to pyrazoles-derivatives compound. In a document, author is Deivasigamani, Gavaskar, introduce the new discover.

A facile atom – economical synthesis of highly substituted pyrazolo-N-methyl-piperidine grafted spiro-indenoquinoxaline pyrrolidine heterocycles via a sequential multicomponent reaction

An expedient one-pot sequential five component synthesis of highly substituted pyrazolo-N-methyl-piperidine grafted spiro-indenoquinoxaline pyrrolidine heterocycles involving [3 + 2]-cycloaddition of azomethine ylides as the key step is described. The protocol provides a mild reaction condition, high yield of the products, high regioselectivity and operational simplicity to assemble complex structural entity in a single operation. The structure of the product was confirmed by spectroscopic techniques and elemental analysis.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 50-33-9. Formula: C19H20N2O2.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Mumtaz, Amara, once mentioned the application of 50-33-9, Name is Phenylbutazone, molecular formula is C19H20N2O2, molecular weight is 308.37, MDL number is MFCD00005500, category is pyrazoles-derivatives. Now introduce a scientific discovery about this category, Category: pyrazoles-derivatives.

Bisthioureas of pimelic acid and 4-methylsalicylic acid derivatives as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP) and intestinal alkaline phosphatase (IAP): Synthesis and molecular docking studies

Alkaline phosphatases (ALPs) are membrane bound metalloenzymes, distributed all over the body. Recent studies have revealed that by targeting ALPs can lead towards the treatment of many deadliest diseases including cardiac, cancerous and brain diseases. Thioureas and their derivatives are of considerable significance and are privileged scaffolds in medicinal chemistry. They show a wide range of pharmacological activities such as an-tibacterial, antiparasitic, anti-inflammatory and antioxidants etc. On the other hand, salicylic acid and its de-rivatives are known for its broad spectrum of activities. The work presented comprises of synthesis of N-acyl-N’- aryl substituted bisthioureas of pimelic acid (1-7) and 3,5-dimethyl pyrazole (11), 1-aroyl-3-aryl thiourea (12) and 1,3,4-oxadiazole (13) derivatives of 4-methyl salicylic acid. Structures of all the synthesized compounds were characterized by FT-IR and H-1 NMR spectroscopic analysis. Synthesized compounds were evaluated for their alkaline phosphatases inhibition potential and exhibited high potency as well as selectivity towards h-TNAP and h-IAP. Compound 7 and 12 which were the bisthiourea derivative of pimmelic acid and thiourea derivative of 4-methyl salicylic acid, respectively, showed excellent selectivity against h-TNAP and h-IAP, respectively.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 50-33-9, Category: pyrazoles-derivatives.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Quality Control of Phenylbutazone, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 50-33-9, Name is Phenylbutazone, molecular formula is C19H20N2O2. In an article, author is Li, Dongying,once mentioned of 50-33-9.

K2CO3-Promoted Pyrazoles Synthesis from 1,3-Dipolar Cycloaddition ofN-Tosylhydrazones with Acetylene Gas

1,3-Dipolar cycloaddition ofN-tosylhydrazones with acetylene gas on balloon was investigated. Bases and solvents were screened and K(2)CO(3)was verified to be an efficient base to promote this process. DMSO gave the better result in the reaction ofN-tosylhydrazones derived from aldehyde, and NMP was a better suitable solvent in the reaction of ketoneN-tosylhydrazones. And a series of pyrazoles were provided in mediate to good yields. This process was easy to handle and suitable to the industrial application.

If you¡¯re interested in learning more about 50-33-9. The above is the message from the blog manager. Quality Control of Phenylbutazone.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 50-33-9, Name is Phenylbutazone, SMILES is O=C(C1CCCC)N(C2=CC=CC=C2)N(C3=CC=CC=C3)C1=O, in an article , author is Yildirim, Fati, once mentioned of 50-33-9, Recommanded Product: Phenylbutazone.

New disazo dyes derived from aminopyrazoles: synthesis, spectroscopic properties, computational study and structural properties

In this study, five new pyrazolyazo pyrazole dyestuff syntheses are reported. For this purpose, 5-amino-4-arylazo-3-methyl-1H-pyrazoles were diazotised and coupled with 3-amino-5-hydroxy-1H-pyrazole. Fourier Transform-infrared, ultraviolet-visible and proton nuclear magnetic resonance spectroscopy were used to investigate the properties of aminopyrazole-based dyes obtained in this study. The maximum absorption wavelengths of these dyes in various solvents were determined. The theoretical calculations of the molecules in the ground state were performed with the density functional theory/Becke 3-parameter and Lee-Yang-Parr/6-311G(d,p) method by using the Gaussian 0.9 W program. The results were compared with the corresponding experimental data. Acid-base and substituent effects on the absorption spectra of dyes were also examined and reported.

Interested yet? Read on for other articles about 50-33-9, you can contact me at any time and look forward to more communication. Recommanded Product: Phenylbutazone.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Recommanded Product: 50-33-9, 50-33-9, Name is Phenylbutazone, SMILES is O=C(C1CCCC)N(C2=CC=CC=C2)N(C3=CC=CC=C3)C1=O, in an article , author is Sharma, Sahil, once mentioned of 50-33-9.

Recent advancements in the development of heterocyclic anti-inflammatory agents

Most of the anti-inflammatory drugs in clinical practice are becoming outdated owing to their potential side and adverse effects. These are found to be highly unsafe for long term use. Thus, since last few years, new anti-inflammatory agents are being developed and number of them are in advanced stages of clinical trials. Heterocyclic molecules have gained great attention of chemists due to their similarity to different biological precursors. In the current review, we have highlighted the recent developments (2015 onwards) in designing and synthesis of various heterocyclic anti-inflammatory molecules along with detailed SAR studies. The principal objective of this review is to provide a profound overview of the recently explored heterocyclic anti-inflammatory agents belonging to various classes such as pyrazole, pyrimidine, benzimidazole, indole, and other related heterocyclic compounds. In addition, an enlarged view on potential interactions of synthetic preparations with target inflammatory enzymes or cytokines has been provided. We have also enlisted lead compounds undergoing different clinical trials against inflammation. The elementary aim of this review is to provide restructured knowledge regarding heterocyclic molecules which will be valuable for the scientists working in the field of anti-inflammatory chemistry. The authors believe that lead compounds mentioned in the report will help to design and develop novel anti-inflammatory drug molecules targeting various factors involved in the progression of inflammation. (C) 2020 Elsevier Masson SAS. All rights reserved.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 50-33-9, you can contact me at any time and look forward to more communication. Recommanded Product: 50-33-9.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Titi, Abderrahim, once mentioned the application of 50-33-9, Name is Phenylbutazone, molecular formula is C19H20N2O2, molecular weight is 308.37, MDL number is MFCD00005500, category is pyrazoles-derivatives. Now introduce a scientific discovery about this category, Product Details of 50-33-9.

One-pot liquid microwave-assisted green synthesis of neutral trans-Cl2Cu (NNOH)(2): XRD/HSA-interactions, antifungal and antibacterial evaluations

In the present work, the ethyl-1-(hydroxymethyl)-5-methy-3-carboxylatel pyrazole)NNOH(polydentate ligand was used to synthesize a new trans-Cl2Cu(NNOH)(2) complex via one-port microwave short procedure using water medium with no side products. The complex composition was analyzed based on FT-IR, UV-Vis, CHN-EA and EDX. Its crystal structure was determined by single crystal X-ray diffraction analysis. Hirshfeld surface analysis (HSA) and two-dimension figure-print (2D-FP) for the complex have been performed. The antibacterial activities were investigated using four types of gram-negative and gram-positive bacteria. Furthermore, the antifungal activities were evaluated using four types of fungi.

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Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics