Category: 187998-35-2

These common heterocyclic compound, 187998-35-2, name is 1-(4-Chlorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C11H9ClN2O2

(3) Reference Example 1 [(trifluoromethyl) pyridin-5-yl] (3) 5-methyl-1 in -1H- pyrazole-4-carboxylic acid in place of Reference Example 6 in 1 – (4-chlorophenyl) -5-methyl -1H- pyrazole-4-carboxylic acid, the reaction process using the same acid under ice-cooling and the reaction mixture (281mg) by 1- (5-amino-3-cyano It was added to a pyridine solution of the no-2-yl) -4-cyano nopi piperidine (228mg) and, after stirring 0.25 hours at the same temperature, tri ethyl amine was added, was stirred at room temperature for 2 hours. After the reaction, water was added, and the precipitated solid was collected and then filtered, washed by suspension to give the title compound (425mg) as a white solid

The synthetic route of 1-(4-Chlorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; Watanabe, Masayuki; Furukawa, Hiroyuki; Hamada, Maiko; Fuji, Naoto; Ushio, Hiroyuki; Takashima, Toru; (81 pag.)KR2015/2661; (2015); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

These common heterocyclic compound, 187998-35-2, name is 1-(4-Chlorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C11H9ClN2O2

(3) Reference Example 1 [(trifluoromethyl) pyridin-5-yl] (3) 5-methyl-1 in -1H- pyrazole-4-carboxylic acid in place of Reference Example 6 in 1 – (4-chlorophenyl) -5-methyl -1H- pyrazole-4-carboxylic acid, the reaction process using the same acid under ice-cooling and the reaction mixture (281mg) by 1- (5-amino-3-cyano It was added to a pyridine solution of the no-2-yl) -4-cyano nopi piperidine (228mg) and, after stirring 0.25 hours at the same temperature, tri ethyl amine was added, was stirred at room temperature for 2 hours. After the reaction, water was added, and the precipitated solid was collected and then filtered, washed by suspension to give the title compound (425mg) as a white solid

The synthetic route of 1-(4-Chlorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; Watanabe, Masayuki; Furukawa, Hiroyuki; Hamada, Maiko; Fuji, Naoto; Ushio, Hiroyuki; Takashima, Toru; (81 pag.)KR2015/2661; (2015); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 187998-35-2, name is 1-(4-Chlorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 1-(4-Chlorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid

To Example 1E (10 mg, 0.037 mniol) and 1-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid (13.7 mg, 0.0580 mmol) in DMF (880 mu), was added DIEA (46.0 mu, 0.264 mmol), followed by addition of BOP (25.7 mg, 0.0580 mmol). The reaction mixture was stirred at rt for 4 h then quenched by the addition of a few a drops of water, diluted with methanol, filtered and purified on preparative HPLC to yield Example 1 (11 mg, 44%) as a white powder. MS (ESI) m/z: 486.0, 1H NMR (500 MHz, DMSO-de) delta 8.20 (s, 1H), 7.92 (br s, 1H), 7.75- 7.43 (m, 3H), 7.33- 7.15 (m, 1H), 6.60 – 6.25 (m, 3H), 3.59 (br d, J=6.1 Hz, 2H), 3.19 (br s, 1H), 2.70 (s, 3H), 2.55 (s, 3H), 1.65 (d, J=6.8 Hz, 2H), 1.02 (d, J=6.3 Hz, 3H).

According to the analysis of related databases, 187998-35-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; GLUNZ, Peter W.; LADZIATA, Vladimir; DE LUCCA, Indawati; TORA, George O.; MAISHAL, Tarun Kumar; TANGIRALA, Raghuram; THIYAGARAJAN, Kamalraj; (216 pag.)WO2019/14308; (2019); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application of 187998-35-2, These common heterocyclic compound, 187998-35-2, name is 1-(4-Chlorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of l-(4-chloro-phenyl)-5-methyl-lH-pyrazole-4-carboxylic acid (1.5 g, 6.3 mmol) in thionyl chloride (18 rnL) is warmed to reflux for 1 hour. After cooling to room temperature, the reaction mixture is concentrated in vacuo to afford l-(4-chloro-phenyl)- 5-methyl-lH-pyrazole-4-carbonyl chloride as a tan solid (1.6 g, 100 %) which is used without further purification.

The synthetic route of 187998-35-2 has been constantly updated, and we look forward to future research findings.