Category: 25016-16-4

Synthetic Route of 25016-16-4, These common heterocyclic compound, 25016-16-4, name is 1-(1H-Pyrazol-4-yl)ethanone, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 3-bromo-5-fluoropyridine (4.1 g, 9.1 mmol), l -(lH-pyrazol-4- yl)ethanone (5, 1.6 g, 9.1 mmol) and Cs2C03(3.55 g, 10.9 mmol) in 15 mL of DMF was heated at 120 C in a microwave oven for 30 minutes. The reaction was cooled to room temperature and diluted with 150 mL of water and filtered. The solid was collected and dried to provide the desired compound (6, 2 g, 7.5 mmol, 83% yield).

Statistics shows that 1-(1H-Pyrazol-4-yl)ethanone is playing an increasingly important role. we look forward to future research findings about 25016-16-4.

Reference:
Patent; ELAN PHARMACEUTICALS, INC.; XU, Ying-Zi; ARTIS, Dean, R.; BOWERS, Simeon; HOM, Roy, K.; SHAM, Hing, L.; YUAN, Shendong; WO2013/142613; (2013); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 25016-16-4, name is 1-(1H-Pyrazol-4-yl)ethanone, A new synthetic method of this compound is introduced below., Formula: C5H6N2O

2-Chloro-N-[(dimethylamino)methylene]-5-nitrobenzenesulfonamide (2.02 g, 6.94 mmol) and 1-(1H-pyrazol-4-yl)ethanone (1.00 g, 10.4 mmol) were dissolved in acetonitrile,powdered potassium carbonate (2.88 g, 20.8 mmol) was added and the reaction mixture was stirred at 10000 overnight. Then, it was concentrated in vacuo and was extracted with dichioromethane/water. The organic phase was washed again with brine, followed by drying over sodium sulfate and concentration in vacuo.As the protection group was partly lost, it was redissolved in DMF (6.6 mL) and 1,1- dimethoxy-N,N-dimethylmethanamine (0.882 g, 7.4 mmol) was added. It was stirred overnight, concentrated in vacuo and extracted with dichloromethane/water. The organic phase was washed again with brine, followed by drying over sodium sulfate and concentration in vacuo to provide 1 .3 g of crude N-[(dimethylamino)methylene]-2-(3-formyl-1 H-pyrazol-1-yl)-5-nitrobenzenesulfonamide.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Electric Literature of 25016-16-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 25016-16-4, name is 1-(1H-Pyrazol-4-yl)ethanone belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Step 1. 1-(1-((6-(trifluoromethyl)pyridin-3-yl)methyl)-1H-pyrazol-4-yl)ethan-1-one Sodium hydride (60% oil dispersion; 800 mg, 20 mmol) was added to a cooled (0 C.) solution of 1-(1H-pyrazol-4-yl)ethanone (2 g, 18.2 mmol) in DMF (20 ml) and stirred for 1 hour at 0 C. 5-(Chloromethyl)-2-(trifluoromethyl)pyridine (3.91 g, 20 mmol) was added to the reaction and allowed to warm to room temperature overnight. The reaction mixture was poured into ice water and extracted with ethyl acetate (3*75 ml). The combined organic extracts were dried over magnesium sulfate, filtered, and evaporated in vacuo. The crude product was purified by column chromatography (SiO2) eluting with a gradient of 0-5% methanol in dichloromethane. The desired fractions were evaporated to afford the title product as a yellow solid. ESMS(M+1)=270.14.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(1H-Pyrazol-4-yl)ethanone, other downstream synthetic routes, hurry up and to see.