Category: 956951-01-2

Some common heterocyclic compound, 956951-01-2, name is 3-Nitro-1H-pyrazole-1-ethanol, molecular formula is C5H7N3O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C5H7N3O3

A solution of 3-nitropyrazole (300mg, 2.65mmol), potassium carbonate (2eq) and 2- bromoethanol (l . leq) in acetonitrile (lOmL) was heated at 60C for 18h. After cooling to rt the mixture was diluted with EtOAc and washed with H20. The organic phase was collected, dried (hydrophobic frit) and concentrated in vacuo. The crude residue was dissolved in methanol (lOmL), palladium on carbon (50mg) was added and the reaction was stirred under a balloon of hydrogen for 18h. The resulting mixture was filtered through Celite and the filtrate concentrated in vacuo to give 2-(3-amino-lH-pyrazol-l-yl)ethanol.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 956951-01-2, its application will become more common.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 956951-01-2, name is 3-Nitro-1H-pyrazole-1-ethanol, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 3-Nitro-1H-pyrazole-1-ethanol

To a stirred solution of compound 95 (4.0 g, 25.477 mmol) in CH2C12 (50 mL) was added triethylamine (8.86 mL, 30.573 mmol) at 0 C and stirred. To this reaction mixture was added methanesulfonyl chloride (2.35 mL, 30.573 mmol) in CH2C12 (5 mL) dropwise over 10 min at 0 C and stirred at the room temperature for 2 h. The reaction was monitored by TLC for complete consumption of compound 95. The reaction mixture was quenched with water (50 mL) and extracted with EtOAc (50 mL x 2). The combined organic layer was washed with brine (50 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford 96 (6 g, crude). 1H NMR (400 MHz, DMSO-d6) delta 3.15 (s, 3H), 4.61 (s, 4H), 7.09 (d, J=2.45 Hz, 1H), 8.09 (d, J=2.45 Hz, 1H). LCMS: 236 (M+H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 956951-01-2.

Reference of 956951-01-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 956951-01-2 name is 3-Nitro-1H-pyrazole-1-ethanol, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A solution 2-(3-nitro-pyrazol-1-yl)-ethanol (3.46 g, 22.02 mmol) in ethanol (40 mL) was placed in a Parr shaker bottle and treated with 10% palladium on carbon (350 mg). The bottle was then put on the Parr shaker and charged with hydrogen to 50 psi and let shake for 1 h. After this time, the reaction mixture was filtered through celite and the celite washed with ethanol. The filtrate was then concentrated in vacuo and azeotroped with acetonitrile and then chloroform to afford 2-(3-amino-pyrazol-1-yl)-ethanol (3.02 g, >quant.) as a light yellow viscous oil: 1H NMR (300 MHz, DMSO-d6 delta ppm 7.26 (d, J=1.83 Hz, 1H), 5.34 (d, J=2.20 Hz, 1H), 4.76 (t, J=5.31 Hz, 1H), 4.50 (s, 2H), 3.78-3.88 (m, 2H), 3.62 (q, J=5.74 Hz, 2H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Nitro-1H-pyrazole-1-ethanol, and friends who are interested can also refer to it.

Related Products of 956951-01-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 956951-01-2, name is 3-Nitro-1H-pyrazole-1-ethanol belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

2- (3-Nitro-lH-pyrazol-l-yl) ethanol (2.48 g, 15.8 mmol) was dissolved in ethyl acetate (15 ml) . 10%wt Pd/C (1 g) was added and the suspension was stirred under hydrogen gas at room temperature for overnight. The suspension was filtered through celite and concentrated in vacuo to give 1.8 g of the title compound (90%) as a light yellow oil. [M+H] calc’d for C5H9N3O, 128 found, 128.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Nitro-1H-pyrazole-1-ethanol, other downstream synthetic routes, hurry up and to see.