75457-13-5, name is 3-Methylquinolin-8-ol, belongs to quinolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C10H9NO
A) A solution of 3-methyl-8-hydroxyquinoline (15.9 g, 0.10 mole) is added to a mixture of 70% nitric acid (162 g, 1.8 mole) (18 molar equivalents) and Manganese dioxide (0.33 g, 0.0038 mole) (0.038 molar equivalents) at a temperature of 80-100 C. over a 1 hour period, with stirring. The resultant overhead gases are scrubbed and vented. The reaction mixture is heated at 100-105 C. for 4 hours, cooled to 85 C., treated with 88% formic acid at 85-95 C. over a 20 minute period, further heated at 85-95 C. for 0.5 hour, cooled to 0 C., stirred for 0.5 hour and filtered. The filtercake is washed with acetone to give 5-methyl-2,3-pyridinedicarboxylic acid, 13.6 g (78.3% yield), 98.8% purity by HPLC analysis.
The synthetic route of 75457-13-5 has been constantly updated, and we look forward to future research findings.