Category: 68500-37-8

Continuously updated synthesis method about 68500-37-8

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 68500-37-8, its application will become more common.

Some common heterocyclic compound, 68500-37-8, name is 4-Chloro-7-methoxyquinoline, molecular formula is C10H8ClNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C10H8ClNO

2-hydroxyacetic acid (5.00 g, 65 mmol) and KOH (6.00 g,90 mmol) were mixed and heated to 170 C. 4-chloro-7-methoxyquinoline (5.00 g, 26 mmol) dissolved in DMSO (20 mL)was added dropwise. The reaction mixture was stirred at 170 C for2.5 h. After cooled to room temperature, the solutionwas poured to50 mL ice water. Saturated aqueous sodium carbonate solutionwasadded to adjust the PH to 7-8. The mixture was filtered and driedin vacuo to give 3.70 g of 4 as brown solid: 62% yield. m.p.:223-225 C; HRMS (ESI+) m/z 234.0763 (234.0761 calcd forC12H12NO4+, [M+H]+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 68500-37-8, its application will become more common.

The important role of 68500-37-8

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 68500-37-8.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 68500-37-8, name is 4-Chloro-7-methoxyquinoline, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 4-Chloro-7-methoxyquinoline

Add 4-chloro-7-methoxyquinoline 5.0g (25.91mmol), 2-fluoro-4-nitrophenol 4.1g (25.91mmol), toluene 50mL and DIPEA 10.1g (77.73mmol) in a 100 mL single-necked flask. After 24 hours of reflux reaction, the reaction was complete by TLC.The reaction liquid was cooled to room temperature, and sand was obtained. Column chromatography gave 5.2 g of pale yellow solid, yield 64.1%

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 68500-37-8.