21168-41-2, name is Ethyl 4,6-dichloroquinoline-3-carboxylate, belongs to quinolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: quinolines-derivatives
A mixture of ethyl-4,6-dichloro-quinoline-3-carboxylate DK-I-35-1 (2 g, 7.4 mmol), 4-methoxyphenylhydrazine hydrochloride (1.55 g, 8.9 mmol), triethylamine (1.80g, 17.8 mmol) and xylenes (16 mL) was heated to reflux (138 oC) and held at reflux for 2 h. The resulting yellow-orange slurry was cooled to 100 oC and diluted with ethanol (16 mL). The reaction mixture was then refluxed at 80oC for 30 min and then cooled to 20-25 oC. The solids were collected by filtration and washed twice with a 1:1 mixture of ethanol (2.5 mL x 2) and hexanes (2.5 mL x 2) and then washed twice with hexanes (5 mL x 2). The solid was dried to afford the product as a yellow powder Comp 11 (1.7 g, 71.0%): 1H NMR (300 MHz, DMSO) delta 12.95 (d, J = 5.6 Hz, 1H), 8.72 (d, J = 6.2 Hz, 1H), 8.14 (d, J = 2.1 Hz, 1H), 8.08 (d, J = 9.0 Hz, 2H), 7.70 (dt, J = 8.9, 5.5 Hz, 2H), 7.02 (d, J = 9.1 Hz, 2H), 3.79 (s, 3H); 13C NMR (75 MHz, DMSO) delta 161.37, 156.48, 141.97, 139.79, 134.59, 133.87, 131.04, 130.46, 122.08, 121.50, 120.89, 120.48, 114.29, 106.86, 55.71; HRMS m/z calculated for C17H13ClN3O2 (M+H)+ 326.0696 found 326.25.
The synthetic route of 21168-41-2 has been constantly updated, and we look forward to future research findings.