Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 104239-97-6, name is (4aR,4bS,6aS,7S,9aS,9bS,11aR)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid, A new synthetic method of this compound is introduced below., name: (4aR,4bS,6aS,7S,9aS,9bS,11aR)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid
3-Oxo-4-aza-5alpha-androst-ene-17beta-carboxylic acid (50 gram) and toluene (750 ml) were mixed together and heated at azeotropic reflux condition for 30 to 60 minutes. (Trace amount of water was removed azeotropically). The resulting solution was cooled to 25 to 35 degree C. under nitrogen atmosphere. Pyridine (6.3 ml) was added to the cooled solution, which was then stirred for about 15 minutes. Then, thionyl chloride (14.0 ml) was added slowly for over 20 minutes. The resulting reaction mixture was maintained at 25-35 C. temperature for about 2-3 hours and then ammonia gas was passed through the reaction mixture till the reaction was completed (8 to 10 hrs). After the completion of the reaction mixture was filtered and washed with toluene (100 ml). The resulting compound was dried for 1-2 hours. The resultant wet material was slurried in water (500 ml) for about 2 hours. Filtered the solid and washed with water (50.0 ml) to get the reaction mass pH up to 6.5 to 7.5. The filtered compound was dried at 70-75 C.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.