Category: 3279-90-1

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3279-90-1 as follows. Safety of 6-Bromo-3,4-dihydro-1H-quinolin-2-one

00104] A solution of 6-bromo-3,4-dihydroquinolin-2(lH)-one, 13 (10.0 g, 44.2 mmol) in THF (25 mL) was added to stirred solution of 60% NaH (3.53 g, 88.4 mmol) in THF (100 mL) at 0 C and the mixture was stirred for 30 min. A solution of 2-(4-(bromomethyl)phenyl)-l,l, l,3,3,3- hexafluoropropan-2-ol, 2 (18.4 g, 55.3 mmol) in THF (25 mL) was added and the mixture was slowly heated to 65 C overnight. The progress of the reaction was monitored by TLC (TLC system: 30 % EtO Ac/Pet ether, Rf value: 0.45). [00105] After completion of the reaction, the reaction mixture was poured into ice cold water and extracted with ethyl acetate (2 x 200 mL). The combined organic layers were dried over anhydrous sodium sulfate and the solvent was removed under reduced pressure to afford crude product. The crude product was washed with pet ether followed by dichloromethane to afford 6- bromo- l-(4-(l,l, l,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)-3,4-dihydroquinolin-2(lH)-one, 14. LC/MS calc M+H 482, obs 482; lH NMR (400 MHz, DMSO-d6) delta: 8.65 (s, 1 H), 7.61 (d, 2 H, J = 8.4 Hz), 7.47 (d, 1 H, J= 2.0 Hz), 7.35-7.30 (m, 3 H), 6.85 (d, 1 H, J= 8.4 Hz), 5.17 (s, 2 H), 2.98 (t, 2 H, J= 6.8 Hz), 2.71 (m, 2 H).

According to the analysis of related databases, 3279-90-1, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3279-90-1, name is 6-Bromo-3,4-dihydro-1H-quinolin-2-one, A new synthetic method of this compound is introduced below., Application In Synthesis of 6-Bromo-3,4-dihydro-1H-quinolin-2-one

Under nitrogen protection,100mL three bottles,The compound 6-bromo-3,4-dihydroquinolin-2 (1H) -one (2.5 g, 11.06 mmol)And N, N-dimethylformamide (2.5 g, 11.06 mmol) were dissolved in dry tetrahydrofuran (50 mL) and cooled to -78 C.A solution of tert-butyllithium (24.1 mL, 38.7 mmol, 1.6 M in pentane) was slowly added dropwise,After completion of the dropwise addition, the reaction was continued at -78 C for 4 hours,Acetic acid (2.5 mL) was added and the temperature was slowly warmed to room temperature.The reaction solution was diluted with ethyl acetate (100 mL) and washed successively with saturated sodium bicarbonate solution and brine. The organic phase was dried, filtered and concentrated to give 2-oxo-1,2,3,4-tetrahydroquinoline-6-carbaldehyde (0.6 g) in 30% yield.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3279-90-1 as follows. SDS of cas: 3279-90-1

To a solution of 6-bromo-3,4-dihydro-1 H-quinolin-2-one (339 mg, 1.50 mmol) in 15 ml dry DMF was added potassium tert-butylate (336 mg, 3.0 mmol). After the mixture was stirred for 30 min at room temperature, a solution of methyl iodide (426 mg, 3.0 mmol) in 5 ml dry DMF was added. Following overnight stirring, the mixture was diluted with 100 ml 1 N HCI.Extraction with ethyl acetate (2 x 100 ml_) followed by washing of the organic extracts with water and brine, drying over MgSO4 and removal of the solvent in vacuo gave a light yellow solid. Purification by flash chromatography (hexanes/ethyl acetate, 7/3, R, = 0.21) gave 6- bromo-1-methyl-3,4-dihydro-1H-quinolin-2-one (281 mg, 1.17 mmol, 78 %) as colorless needles.

According to the analysis of related databases, 3279-90-1, the application of this compound in the production field has become more and more popular.