Category: 129768-30-5

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 129768-30-5 as follows. category: pyrazoles-derivatives

Example 11; N-(2-ethoxybenzyl)-1-(1-(2-(methylamino)ethyl)piperidin-4-yl)-3-(trifluoromethyl)-1 H-pyrazole-5-carboxamide (98); Step 1 tert-butyl 4-(5-(ethoxycarbonyl)-3-(trifluoromethyl)-1 H-pyrazol-1-yl)piperidine-1- carboxylate (93); [0268] tert-Butyl 4-iodopiperidine-i-carboxylate (5 683, 18 26 mmol, E G Corley et al, JOC, 2004, 69, 5120-5123) in DMF (30 7 ml) was added to a mixture of ethyl 3- (trifluoromethyl)-1 H-pyrazole-5-carboxylate (3 2 g, 15 37 mmol, M -A Plancquaert et al, Tetrahedron, 52, 4383-4396) and potassium carbonate 95 31 g, 38 4 mmol) and the mixture was stirred at 80oC for 16h After cooling, water was added and the mixture was extracted with EtOAc, and the organic extraxts were dried, filtered and concentrated Chromatographic purification of the residue by Biotage (5-20% EtOAc m Hexanes, 25M column) gave compound 93 as colorless oil (2 4 g, 39 9% yield) LFRMS (ESI) calc 391 4, found 414 1 (M+Na)+

According to the analysis of related databases, 129768-30-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; METHYLGENE INC.; WO2008/104077; (2008); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthetic Route of 129768-30-5,Some common heterocyclic compound, 129768-30-5, name is Ethyl 3-(Trifluoromethyl)pyrazole-5-carboxylate, molecular formula is C7H7F3N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of ethyl 3-(trifluoromethyl)-lH-pyrazole-5-carboxylate (2 g, 9.615 mmol, 1 eq) in THF (30 ml) was added LiAlH4 (1.09g, 28.846 mmol, 3 eq), portionwise at 0C for 10 min. The RM was stirred at RT for 2h.The RM was quenched with sat Na2S04 (50 ml) and most of the solvent was removed under reduced pressure. The residue was diluted with water (100 ml) and extracted with EtOAc (3x 100 ml). The combined organic layers were washed with brine (100ml), dried(Na2S04) and concentrated to afford the title compound (1.5 g, 94%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 3-(Trifluoromethyl)pyrazole-5-carboxylate, its application will become more common.

Reference:
Patent; GRUeNENTHAL GMBH; SCHUNK, Stephan; REICH, Melanie; KOENIGS, Rene, Michael; (72 pag.)WO2017/59966; (2017); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 129768-30-5 as follows. category: pyrazoles-derivatives

Example 11; N-(2-ethoxybenzyl)-1-(1-(2-(methylamino)ethyl)piperidin-4-yl)-3-(trifluoromethyl)-1 H-pyrazole-5-carboxamide (98); Step 1 tert-butyl 4-(5-(ethoxycarbonyl)-3-(trifluoromethyl)-1 H-pyrazol-1-yl)piperidine-1- carboxylate (93); [0268] tert-Butyl 4-iodopiperidine-i-carboxylate (5 683, 18 26 mmol, E G Corley et al, JOC, 2004, 69, 5120-5123) in DMF (30 7 ml) was added to a mixture of ethyl 3- (trifluoromethyl)-1 H-pyrazole-5-carboxylate (3 2 g, 15 37 mmol, M -A Plancquaert et al, Tetrahedron, 52, 4383-4396) and potassium carbonate 95 31 g, 38 4 mmol) and the mixture was stirred at 80oC for 16h After cooling, water was added and the mixture was extracted with EtOAc, and the organic extraxts were dried, filtered and concentrated Chromatographic purification of the residue by Biotage (5-20% EtOAc m Hexanes, 25M column) gave compound 93 as colorless oil (2 4 g, 39 9% yield) LFRMS (ESI) calc 391 4, found 414 1 (M+Na)+

According to the analysis of related databases, 129768-30-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; METHYLGENE INC.; WO2008/104077; (2008); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 129768-30-5 as follows. COA of Formula: C7H7F3N2O2

Reference Synthesis Example 55 (0639) 5-(Chloromethyl)-3-(trifluoromethyl)-1H-pyrazole (0640) To a tetrahydrofuran solution (4 mL) of ethyl 3-(trifluoromethyl)-1H-pyrazol-5-carboxylate (104 mg, 0.50 mmol), diisobutylaluminum hydride (1.75 mL, 1.75 mmol, toluene solution) was added at 0 C. and the resultant solution was stirred for 2 hours. To the reaction solution, saturated sodium sulfate aqueous solution was added and the resultant mixture was dried over anhydrous magnesium sulfate and concentrated under reduced pressure. Subsequently, to a dichloromethane solution of the obtained residue (28 mg), thionyl chloride (39.4 mg, 0.33 mmol) was added and the resultant mixture was stirred at room temperature for 1 day. After completion of the reaction, the reaction solution was concentrated under reduced pressure to obtain a crude product of the title compound. The crude product was used in the next reaction as it was.

According to the analysis of related databases, 129768-30-5, the application of this compound in the production field has become more and more popular.

Related Products of 129768-30-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 129768-30-5, name is Ethyl 3-(Trifluoromethyl)pyrazole-5-carboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a solution of ethyl 3-(trifluoromethyl)-li/-pyrazole-5-carboxylate (1.00 g, 4.80 mmol) in l,2-dichloroethane (40 mL) were added cyclopropylboronic acid (0.825 g, 9.61 mmol) and sodium carbonate (1.02 g, 9.61 mmol). The reaction mixture was warmed to 70 C and 2,2′- bipyridine (0.750 g, 4.80 mmol) and copper(II) acetate (0.873 g, 4.80 mmol) were added and the reaction mixture was allowed to stir for 18 h at 70 C. The reaction mixture was cooled to ambient temperature and diluted with a saturated aqueous solution of sodium bicarbonate and extracted with ethyl acetate (2 x). The combined organic extracts were washed with a saturated aqueous solution of sodium chloride and concentrated under reduced pressure. The residue was purified by silica gel chromatography, eluting with a gradient of hexanes: ethyl acetate – 95:5 to 50:50 to afford the title compound. MS: m/z = 249.1 [M+H]

The synthetic route of Ethyl 3-(Trifluoromethyl)pyrazole-5-carboxylate has been constantly updated, and we look forward to future research findings.