Category: 27258-32-8

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 27258-32-8 as follows. Recommanded Product: 27258-32-8

17. Preparation of 3-difluoromethyl-1-methylpyrazole from 1-methylpyrazole-3-carbaldehydeAt -20° C., (diethylamino)sulfur trifluoride (DAST, 87.8 g, 0.54 mol) was added dropwise to a solution of 1-methylpyrazole-3-carbaldehyde (20 g, 0.18 mol) in methylene chloride (200 ml). The reaction mixture was stirred at room temperature overnight. The reaction mixture was then added carefully to ice/water (400 g) and extracted twice with methylene chloride (100 ml each). The combined organic phase was washed twice with water (100 ml each) and twice with NaCl solution (100 ml each) and dried over magnesium sulfate, and the solvent was removed under reduced pressure. The residue was separated by fractional distillation. 3-Difluoromethyl-1-methylpyrazole (16.5 g, transition temperature 141° C. at 570 mbar) was isolated in a purity of 95percent. This corresponds to a yield of 66.8percent.

According to the analysis of related databases, 27258-32-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BASF SE; US2010/174094; (2010); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 27258-32-8, name is 1-Methyl-1H-pyrazole-3-carbaldehyde, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 27258-32-8, Recommanded Product: 1-Methyl-1H-pyrazole-3-carbaldehyde

in room temperature, Mix 1-methyl-1H-pyrazole-3-carbaldehyde (11.0 g, 0.1 mol), sodium bromate (4.5 g, 0.03 mol) and 100 g of acetic acid (1.67 mol), add 25 g of ammonia-containing molecular mass concentration 25percent ammonia water and 400 ml water, heated to 90 ° C, the reaction exotherm, maintain the reaction temperature 100 ° C, reflux reaction for 1 hour until 1-methyl-1H-pyrazole-3-carbaldehyde reaction is complete, the reaction solution is cooled to room temperature Pour into ice water to quench and dilute, neutralize until the reaction solution is neutral, extract with ethyl acetate, dry, concentrate the product, distill it under reduced pressure and recrystallize to obtain 8.6 g of product, yield 80percent, purity 98percent the above.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-pyrazole-3-carbaldehyde, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Changsha Luxing Biological Technology Co., Ltd.; Tan Yongjun; (14 pag.)CN108707113; (2018); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

27258-32-8, name is 1-Methyl-1H-pyrazole-3-carbaldehyde, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C5H6N2O

[00346] 55A. 3-((2-(4-bromophenyl)hydrazono)methyl)-l-methyl-lH-pyrazole: To a solution of (4-bromophenyl)hydrazine hydrochloride (1 150 mg, 5.04 mmol) and 1- methyl-lH-pyrazole-3-carbaldehyde (580 mg, 5.00 mmol) in DMF (5.1 mL) was added triethylamine (0.84 mL, 6.00 mmol). The mixture was stirred at rt under argon for 21 h, water (9 mL) was added and stirring was continued for 1 h. The solid that resulted was filtered, rinsed with water (5 mL) and dissolved in CH2C12 (120 mL). The CH2C12 solution was dried (Na2S04) and concentrated to provide 55A (1400 mg, 5.02 mmol, 100 percent yield) as a yellowish solid: lH NMR (400MHz, CDC13) d 7.76 (s, 1H), 7.63 (s, 1H), 7.34 (m, 3H), 6.97 (d, J= 8.8 Hz, 2H), 3.91 (s, 3H).

The synthetic route of 27258-32-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; HERNANDEZ, Andres S.; ELLSWORTH, Bruce A.; EWING, William R.; CHEN, Bin; WO2014/78608; (2014); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 27258-32-8, name is 1-Methyl-1H-pyrazole-3-carbaldehyde belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 27258-32-8

To (E)-3-(2-((5-methyl-2 H-tetrazol-2-yl)methyl)-4-(trifluoromethyl) phenyl)- 1 -(piperazin- 1- yl)prop-2-en-1-one (Example 88, step 2) (110 mg, 0.289 mmol) in methanol (2.62 1 mL) was added acetic acid (0.262 m L) and 1-methyl-i H-pyrazole-3-carbaldehyde (commerciallyavailable) (47.8 mg, 0.434 mmol) and the mixture was stirred for 5 minutes. 2-Picoline borane (49.0 mg, 0.463 mmol) was added and the mixture was stirred at room temperature for 18 h. The solvent was removed under reduced pressure. Purification of the crude product by chromatography on silica using a gradient from 0 – 100percent EtOAc in iso-hexane followed by methanol in EtOAc (10percent) afforded the title compound;LC-MS: Rt = 2.i6mins; [M+H] 475.4, Method 8minLowpHvoi.1H NMR (400 MHz, DMSO-d6) O 8.07 (1H, d), 7.85 (1H, 5), 7.80 (1H, d), 7.75 (1H, d), 7.6 (1H, 5), 7.24 (1H, 5), 6.15-6.07 (3H, mult), 3.79 (3H, 5), 3.67-3.50 (4H, mult), 3.48-3.28 (4H, mult), 2.44-2.32 (7H, mult).

The synthetic route of 27258-32-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NOVARTIS AG; BEATTIE, David; BAETTIG, Urs; LEGRAND, Darren Mark; LISTER, Andrew Stuart; MCKENNA, Jeffrey; PEARCE, David William; SANDHAM, David Andrew; STEWARD, Oliver Ross; THOMSON, Christopher; WO2015/8230; (2015); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 27258-32-8, name is 1-Methyl-1H-pyrazole-3-carbaldehyde, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 27258-32-8, SDS of cas: 27258-32-8

To a solution of 1-methyl-1H-pyrazole-3-carbaldehyde (150 g, 1.36 mol) in DMF (1000 mL) was added NBS (240 g, 1.35 mol). The resulting solution was stirred for 2 h at 50¡ã C. and then was quenched by the addition of ice water (2000 mL). The reaction mixture was cooled to ?10¡ã C. with an ice/salt bath, and the solids were collected by filtration to provide the desired product as a white solid (200 g, 78percent). 1H NMR (300 MHz, CDCl3): delta 9.90 (d, J=0.7 Hz, 1H), 7.46 (s, 1H), 3.96 (s, 3H) ppm.

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