Category: 112029-98-8

Electric Literature of 112029-98-8,Some common heterocyclic compound, 112029-98-8, name is (1-Methyl-1H-pyrazol-4-yl)methanol, molecular formula is C5H8N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step B 4-(methoxymethyl)-1-methyl-1,1-pyrazole To a suspension of sodium hydride (0.128 g, 3.21 mmol) in tetrahydrofuran (5 mL, 60 mmol) at 0° C. was added (1-methyl-1H-pyrazol-4-yl)methanol (0.300 g, 2.68 mmol) in tetrahydrofuran (2 mL, 20 mmol). The reaction was stirred at room temperature for 1 h, and then cooled down with ice bath. Methyl iodide (0.83 mL, 13 mmol) was added. The reaction was stirred at room temperature overnight. The reaction mixture was quenched with brine and extracted with EtOAc (3*). The combined organic phases were washed with water, brine, then dried over Na2SO4, and concentrated under reduced pressure to give 261 mg (77.2percent yield) of the desired product as colorless oil, which was directly used for the next reaction. LC/MS found: 127.2 (M+1)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (1-Methyl-1H-pyrazol-4-yl)methanol, its application will become more common.

Reference:
Patent; Incyte Corporation; Huang, Taisheng; Feng, Hao; Kong, Lingquan; Wang, Anlai; Ye, Hai Fen; US2013/96144; (2013); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

These common heterocyclic compound, 112029-98-8, name is (1-Methyl-1H-pyrazol-4-yl)methanol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 112029-98-8

To a cooled solution of (1-methyl-1H-pyrazol-4-yl)-methanol (8.61 g, 0.076 mole) in DCM (100 mL) under N2 atmosphere, thionyl chloride (8.7 mL, 0.12 mole) was added drop wise. The reaction mixture was warmed to RT and stirred for 2 hours. The reaction mixture was concentrated under vacuum at 23 ? 25 °C to obtain the titlecompound.Yield: 12.77 g (99 percent); ?H – NMR (DMSO-d6, 400 MHz) oe ppm: 3.85 (s, 3H), 4.67 (s, 2H), 4.76 – 4.79 (t, 1H), 4.88 (bs, 1H), 7.47 (s, 1H), 7.78 (s, 1H).

The synthetic route of (1-Methyl-1H-pyrazol-4-yl)methanol has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SUVEN LIFE SCIENCES LIMITED; NIROGI, Ramakrishna; SHINDE, Anil Karbhari; MOHAMMED, Abdul Rasheed; SUBRAMANIAN, Ramkumar; BENADE, Vijay Sidram; BHYRAPUNENI, Gopinadh; JASTI, Venkateswarlu; (89 pag.)WO2017/42643; (2017); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application of 112029-98-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 112029-98-8 name is (1-Methyl-1H-pyrazol-4-yl)methanol, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Under a stream of nitrogen, cyanomethylenetributylphosphorane (0.06 mL) was dropped into a 0.2-mL toluene solution of the compound (30 mg) produced in Reference Example 20 and (1-methylpyrazol-4-yl)methanol (9.6 mg), and the mixture was stirred overnight at 100C. The reaction mixture was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography to obtain the title compound (7 mg) having the following physical property values. 1H-NMR (CDCl3): delta 1.26, 1.39-1.42, 1.68-1.85, 2.28-2.51, 2.55-2.65, 2.83-3.05, 3.87-4.01, 4.04-4.18, 4.89, 6.40, 6.72-6.79, 7.06-7.38, 7.41, 7.51, 8.77, 9.13.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, (1-Methyl-1H-pyrazol-4-yl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; Ono Pharmaceutical Co., Ltd.; YOSHIDA, Takao; SHOYAMA, Akiko; TAKANO, Hirotsugu; (103 pag.)EP3482760; (2019); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 112029-98-8, name is (1-Methyl-1H-pyrazol-4-yl)methanol, A new synthetic method of this compound is introduced below., HPLC of Formula: C5H8N2O

To a neat mixture of 3-(3-((6-fluoropyridin-3-yl)methyl)isoxazol-5-yl)pyridin-2 -amine (Intermediate E, 50 mg, O. l9mmol) and 1 -methyl -lH-pyrazol -4 -yl -methanol (207mg, l.85mmol) was added potassium 2-methylpropane-2-olate (1M in THF, l.85mL, l.85mmol) and the mixture was stirred for 30min. The mixture was transferred to a silica gel samplet which was subsequently loaded on to a Biotage Snap column. The residue was purified by column chromatography (Si02, hexane/ethyl acetate). Combined fractions were concentrated under reduced pressure. Residue was dissolved in acetonitrile (5mL) and water (lOmL), frozen and lyophilized to yield 3-(3-((6-((l-methyl-lH-pyrazol-4- yl)methoxy)pyridin-3-yl)methyl)isoxazol-5-yl)pyridin-2-amine (8.5mg, 0.023mmol, 13%) as a white solid. MS: 363.2 [M+H]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Related Products of 112029-98-8,Some common heterocyclic compound, 112029-98-8, name is (1-Methyl-1H-pyrazol-4-yl)methanol, molecular formula is C5H8N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Intermediate 70 (160mg, 1 eq.) was dissolved in re-distilled dichloromethane, and dichlorosulfoxide (310 mul, 3 eq.) was added under ice bath. The mixture was reacted for 1 h, evaporated to remove solvent. The product was directly used in the next step without purification

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (1-Methyl-1H-pyrazol-4-yl)methanol, its application will become more common.

Application of 112029-98-8, These common heterocyclic compound, 112029-98-8, name is (1-Methyl-1H-pyrazol-4-yl)methanol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Under a stream of nitrogen, cyanomethylenetributylphosphorane (0.06 mL) was dropped into a 0.2-mL toluene solution of the compound (30 mg) produced in Reference Example 20, and (1-methylpyrazol-4-yl)methanol (9.6 mg), and the mixture was stirred overnight at 100C. The reaction mixture was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography to obtain the title compound (7 mg) having the following physical property values. 1H-NMR (CDCl3): delta 1.26, 1.39-1.42, 1.68-1.85, 2.28-2.51, 2.55-2.65, 2.83-3.05, 3.87-4.01, 4.04-4.18, 4.89, 6.40, 6.72-6.79, 7.06-7.38, 7.41, 7.51, 8.77, 9.13.

The synthetic route of 112029-98-8 has been constantly updated, and we look forward to future research findings.

Application of 112029-98-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 112029-98-8, name is (1-Methyl-1H-pyrazol-4-yl)methanol belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

[00775] Compound 58-a was synthesized according to Method A. Amide 58-b was synthesized from compound 58-a and 2-aminopyrazolo[ 1 ,5-a]pyrimidine-3-carboxylic acid according to Method D. Potassium teftbutoxide (0.25 mmol, 1.5 equiv was then suspended in anhydrous tetrahydrofuran (1 mL). A solution of (1-methyl- 1H-pyrazol-4-yl)methanol in tetrahydrofuran (1 mL) was then added and the mixture was heated to 40 ¡ãC. A solution of compound 58-b (0.17 mmol, 1.0 equiv) in tetrahydrofiaran (1 mL) was added and the temperature was increased to 60 ¡ãC. The reaction was heated for 45 mm after which there was no more starting material by LC/MS analysis. The mixture was cooled and poured into brine and then extracted with ethylacetate (2x). The combined organic layers were dried and concentrated onto silica gel (2g). The residue was then purified using flash silica gel chromatography (ISCO, Si-i 2g column, gradient of 0-10percent methanol, methylene chloride). The product containing fractions were then concentrated and further purified using reverse phase HPLC (Interchim-sunfire, gradient of 5- 50percent acetonitrile water, ammonium bicarbonate buffer) to provide compound 67 as the desired product. ESI-MS m/z: 535.4 [M+H]+.

The synthetic route of (1-Methyl-1H-pyrazol-4-yl)methanol has been constantly updated, and we look forward to future research findings.

Application of 112029-98-8, These common heterocyclic compound, 112029-98-8, name is (1-Methyl-1H-pyrazol-4-yl)methanol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To the solution of alcohol 4b (0.50?g, 2.67?mmol) and DMSO (0.41?g, 5.34?mmol) in ethyl acetate (5?ml) was added ?T3P (1.84?g, 6.68?mmol, 2.5?equiv, 50percent solution in ethyl acetate) at 0?¡ãC. The resulting mixture was allowed to warm to RT and stirred for 1?h. Pyrazine-2-amine 3a (0.254?g, 2.67?mmol) was added to the above mixture and stirred for 15?min, which was followed by the addition of isocyanide 1c (0.33?g, 4.01?mmol) at room temperature and stirring for 4?h. Progress of the reaction was monitored by TLC. After the reaction was complete, the reaction mixture was diluted with ethyl acetate and neutralized with aqueous sodium bicarbonate solution. The organic layer was separated and the aqueous layer was extracted with ethyl acetate (25?mL?¡Á?2), the combined organic phases were washed with water, brine solution, dried over anhydrous sodium sulfate, and concentrated under vacuum to afford a crude product, which was purified on silica gel using ethyl acetate and petroleum ether.

Statistics shows that (1-Methyl-1H-pyrazol-4-yl)methanol is playing an increasingly important role. we look forward to future research findings about 112029-98-8.