Category: 4054-67-5

These common heterocyclic compound, 4054-67-5, name is 3,3′,5,5′-Tetramethyl-1H,1’H-4,4′-bipyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 4054-67-5

General procedure: A mixture of H2L (0.15 mmol, 0.057 g), phen (0.25 mmol, 0.050 g), Zn(Ac)2·2H2O (0.40 mmol, 0.088 g) and 12 mL H2O was placed in a 25 mL Teflon-lined stainless steel container, heated to 180 C for 72 h,and then cooled to room temperature at a rate of 5 C/h.

The synthetic route of 3,3′,5,5′-Tetramethyl-1H,1’H-4,4′-bipyrazole has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wang, Jun; Bai, Chao; Hu, Huai-Ming; Yuan, Fei; Xue, Gang-Lin; Journal of Solid State Chemistry; vol. 249; (2017); p. 87 – 97;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application of 4054-67-5,Some common heterocyclic compound, 4054-67-5, name is 3,3′,5,5′-Tetramethyl-1H,1’H-4,4′-bipyrazole, molecular formula is C10H14N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The ligands 5-(4-carboxyphenoxy)isophthalicacid (H3L) (0.10 mmol, 0.031 g) and 3,3?,5,5?-tetramethyl-4,4?-bipyrazole(bpz) (0.10 mmol, 0.020 g) as well as Cd(OOCCH3)2·2H2O(0.10 mmol, 0.027 g) were dissolved in 10 mL of H2O and the mixturewas stirred for 30 min and then transferred and sealed in a 25 mLTeflon-lined reactor and heated to 160 C for 72 h, and thereafter cooledto room temperature at a rate of 5 C/h. Yellow block crystals of 1 wereobtained in 62% yield based on cadmium. IR: 3397(v); 2924(m);1615(m); 1557(vs); 1509(m); 1450(s); 1372(vs); 1246(vs); 1108(m);970(m); 779(m); 724(m); 640(m).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,3′,5,5′-Tetramethyl-1H,1’H-4,4′-bipyrazole, its application will become more common.

Reference:
Article; Cai, Shu-Lan; Lu, Lu; Wu, Wei-Ping; Wang, Jun; Sun, Yan-Chun; Ma, Ai-Qing; Singh, Amita; Kumar, Abhinav; Inorganica Chimica Acta; vol. 484; (2019); p. 291 – 296;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

4054-67-5, name is 3,3′,5,5′-Tetramethyl-1H,1’H-4,4′-bipyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 4054-67-5

A mixture of Co(CH3COO)2·4H2O (0.050 g, 0.20 mmol), H2bpdc (0.072 g, 0.30 mmol) and H2bpz (0.038 g, 0.20 mmol) in DMF (5 mL) and CH3CN (5 mL) was placed in a Teflon-lined stainless steel vessel (15 mL). The vessel was heated at 140 C for 72 h, then slowly cooled to room temperature. The purple crystals of 1 were isolated by filtrating, washing with DMF, and dried in vacuo. Yield: 24 mg (23.4%). Anal. Calcd for C44H54Co2N6O15: C, 51.57; H, 5.31; N, 8.20%. Found: C, 51.45; H, 5.17; N, 8.11%. IR (KBr, cm-1): 3426(vs), 2919(w), 1680(s), 1605(s), 1540(m), 1394(s), 1297(m), 1172(w), 1130(w), 851(m), 765(s).

The synthetic route of 4054-67-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Jia, Li-Na; Zhao, Yang; Hou, Lei; Cui, Lin; Wang, Hai-Hua; Wang, Yao-Yu; Journal of Solid State Chemistry; vol. 210; (2014); p. 251 – 255;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application of 4054-67-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4054-67-5, name is 3,3′,5,5′-Tetramethyl-1H,1’H-4,4′-bipyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: ,3?,5,5?-Tetramethyl-4,4?-bipyrazole (Me4bpz) was synthesized according to literature methods [33], using acetyl acetone (Acros, 99+ %), sodium hydride (Acros, 60% dispersion in mineral oil), iodine (Sigma-Aldrich, 99.8%) as well as hydrazine hydrate (Merck, ca. 100%). Diethyl ether was dried with sodium/benzophenone and stored under nitrogen atmosphere. All other solvents were used as obtained. Diphenic acid (Acros, 99%) as well as the metal acetate hydrates were used as obtained from the distributors stated above. Metal acetate hydrates, diphenic acid and 3,3?,5,5?-tetramethyl-4,4?-bipyrazole were reacted under hydrothermal conditions (solvent volume: 5 ml) in amounts specified in Table 1 . The autoclaves of type 4749 (Parr, volume 23 ml, Teflon liner, Tmax = 250 C, pmax = 124 bar) were tempered using a drying oven ULE400 (Memmert) with RS232-interface and the control software CELSIUS2000 (Memmert). The reaction vessels were heated to 150 C within 10 h. After 20 h at 150 C the autoclaves were cooled to 25 C within 120 h with constant cooling rate. The generated crystalline solids were filtrated from the liquids and washed with 50 ml hot water and 50 ml hot methanol. Thereafter the products were dried at 120 C in a drying oven. All syntheses were performed at least two times to ensure reproducibility of the results.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,3′,5,5′-Tetramethyl-1H,1’H-4,4′-bipyrazole, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Hunger, Jens; Inorganica Chimica Acta; vol. 397; (2013); p. 60 – 68;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

These common heterocyclic compound, 4054-67-5, name is 3,3′,5,5′-Tetramethyl-1H,1’H-4,4′-bipyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 3,3′,5,5′-Tetramethyl-1H,1’H-4,4′-bipyrazole

General procedure: A mixture of H2L (0.15 mmol, 0.057 g), phen (0.25 mmol, 0.050 g), Zn(Ac)2·2H2O (0.40 mmol, 0.088 g) and 12 mL H2O was placed in a 25 mL Teflon-lined stainless steel container, heated to 180 C for 72 h,and then cooled to room temperature at a rate of 5 C/h.

The synthetic route of 3,3′,5,5′-Tetramethyl-1H,1’H-4,4′-bipyrazole has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wang, Jun; Bai, Chao; Hu, Huai-Ming; Yuan, Fei; Xue, Gang-Lin; Journal of Solid State Chemistry; vol. 249; (2017); p. 87 – 97;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthetic Route of 4054-67-5,Some common heterocyclic compound, 4054-67-5, name is 3,3′,5,5′-Tetramethyl-1H,1’H-4,4′-bipyrazole, molecular formula is C10H14N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The ligands 5-(4-carboxyphenoxy)isophthalicacid (H3L) (0.10 mmol, 0.031 g) and 3,3?,5,5?-tetramethyl-4,4?-bipyrazole(bpz) (0.10 mmol, 0.020 g) as well as Cd(OOCCH3)2·2H2O(0.10 mmol, 0.027 g) were dissolved in 10 mL of H2O and the mixturewas stirred for 30 min and then transferred and sealed in a 25 mLTeflon-lined reactor and heated to 160 C for 72 h, and thereafter cooledto room temperature at a rate of 5 C/h. Yellow block crystals of 1 wereobtained in 62% yield based on cadmium. IR: 3397(v); 2924(m);1615(m); 1557(vs); 1509(m); 1450(s); 1372(vs); 1246(vs); 1108(m);970(m); 779(m); 724(m); 640(m).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,3′,5,5′-Tetramethyl-1H,1’H-4,4′-bipyrazole, its application will become more common.

Reference:
Article; Cai, Shu-Lan; Lu, Lu; Wu, Wei-Ping; Wang, Jun; Sun, Yan-Chun; Ma, Ai-Qing; Singh, Amita; Kumar, Abhinav; Inorganica Chimica Acta; vol. 484; (2019); p. 291 – 296;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4054-67-5, name is 3,3′,5,5′-Tetramethyl-1H,1’H-4,4′-bipyrazole, This compound has unique chemical properties. The synthetic route is as follows., name: 3,3′,5,5′-Tetramethyl-1H,1’H-4,4′-bipyrazole

General procedure: A mixture of Ag2O (11.6 mg, 0.05 mmol), bpz (19 mg, 0.1 mmol), maleic acid (11.6 mg, 0.1 mmol), 5 mL H2O, and 0.15 mL pyridine was heated to 90 C for 8 h in a 25 mL Teflon-lined reaction vessel, kept at 90 C for 50 h, then slowly cooled to 30 C in 10 h. The pH values of the system were 6.06 and 6.10 before and after the hydrothermal reaction, respectively. Colorless block crystals of 1 were isolated by filtration, washed with H2O, and dried in air.

According to the analysis of related databases, 4054-67-5, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4054-67-5 as follows. name: 3,3′,5,5′-Tetramethyl-1H,1’H-4,4′-bipyrazole

A mixture of H4L (0.05 mmol, 0.023 g), bpz (0.10 mmol, 0.020 g), Co(NO3)26H2O (0.15 mmol, 0.044 g) and 6mL of acetonitrile/H2O (v/v 1:1) was stirred for 30 min and then transferred and sealed in a 25mL Teflon-lined reactor and heated to 120 C for 72 h, and then cooled toroom temperature at a rate of 5 C/h. Red block crystals of 1 were obtained in 58% yield based on cobalt. Calcd (%) for C34H30N4O11Co2, C,51.79; H, 3.84; N, 7.11. Found C, 51.35; H, 3.49; N, 7.01. IR: 3393(vs);3176(m); 2933(m); 2355(m); 1605(v); 1524(m); 1443(v); 1261(m);1128(v); 1037(m); 774(m); 733(m).

According to the analysis of related databases, 4054-67-5, the application of this compound in the production field has become more and more popular.