Synthetic Route of 111493-52-8,Some common heterocyclic compound, 111493-52-8, name is 5-Chloro-1-methyl-1H-pyrazole-4-carbonitrile, molecular formula is C5H4ClN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 4: 5-(5-chloro- l -methyl-lH-pyrazole-4-yl)-2H-tetrazole The above product, 5-chloro- l -methyl- lH-pyrazole-4-carbonitrile ( 13.0 gm, 0.092 moles), was dissolved in DMF (40 ml), followed by addition of ammonium chloride (9.9 gm, 0.184 moles) and sodium azide (12.0 gm, 0.184 moles) and stirred at 100- 140C for 10- 16 hours. The progress of the reaction was monitored by HPLC. The reaction mixture was cooled at 0- 5C and quenched with aqueous HC1 (78.0 ml) and stirred for 30-60 min at 0-5C. The solid material obtained was filtered, washed with cold DM water (40 ml) and dried at 60-65C to yield the product, 5-(5-chloro-l -methyl- lH-pyrazole-4-yl)-2H-tetrazole Dry wt : 16.2 gm Yield . : 1 .25 w/w (96%) HPLC purity : 99.26% MP : 215-219C
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Chloro-1-methyl-1H-pyrazole-4-carbonitrile, its application will become more common.