Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 40261-59-4, name is 1-Phenyl-1H-pyrazole-3-carbaldehyde, A new synthetic method of this compound is introduced below., Recommanded Product: 40261-59-4
Step 1 : l-(l-Phenyl-lH-pyrazol-3-yl)-propan-l-ol[0142] 1 -Phenyl- lH-pyrazole-3-carbaldehyde (779 mg, 4.53 mmol) was dissolved in anhydrous TEtaF (9 mL) and chilled in an ice bath. EtMgBr (3.0 M in Et20, 4.5 mL) was added dropwise. After 1.5 hours, the reaction mixture was allowed to warm to ambient temperature. TLC (2:1 hexanes:EtOAc indicated complete consumption of aldehyde starting material. The reaction mixture was quenched with water and extracted with EtOAc (2x). The EtOAc layers were washed with brine (Ix), dried over Na2SO4 and concentrated. The residue was purified by silica gel chromatography (2:1 hexanes: EtOAc) to provide the title compound (631 mg, 69%) as a yellow oil. 1H NMR (400 MHz, CDCl3) delta 7.85 (d, IH, J= 2.4 Hz), 7.65 (d, 2H, J= 7.6 Hz), 7.42 (t, 2H, J= 7.6 Hz), 7.27 (d, IH, J= 7.2 Hz), 6.38 (d, IH, J = 2.4 Hz), 4.79 (dd, IH, J= 12, 5.6 Hz), 2.38 (d, IH, J= 4.8 Hz), 1.98-1.81 (m, 2H), 1.01 (t, 3H, J= 7.2 Hz). MS (ES) m/z 203.1 (M+H+).
The synthetic route of 40261-59-4 has been constantly updated, and we look forward to future research findings.