Category: 871239-17-7

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 871239-17-7, name is 3-Bromo-1-(2-chlorophenyl)-1H-pyrazole-5-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 3-Bromo-1-(2-chlorophenyl)-1H-pyrazole-5-carboxylic acid

Step H: Preparation of 2-[3-bromo-1-(2-chlorophenyl)-1H-pyrazol-5-yl]-8-methyl-4- oxo-4H-3,1-benzoxazine-6-carbonitrile; To a solution of 3-bromo-1- (2-chlorophenyl)-1H-pyrazole-5-carboxylic (i. e. the carboxylic acid product of Step E) (2.0 g, 6.29 mmol) and 2-amino-3-methyl-5- cyanobenzoic acid (i. e. the product of Step G) (1.1 g, 6.29 mmol) in acetonitrile (60 mL) at room temperature was added 3-picoline (3.2 mL, 32.7 mmol). The reaction mixture was stirred for 5 minutes and then cooled to-10 C. Methanesulfonyl chloride (1.3 mL, 16.4 mmol) was then added dropwise, and after completion of the addition the reaction mixture was warmed to room temperature. On stirring overnight at room temperature, the reaction mixture formed a solid precipitate. The solid was isolated by filtration, washed with water, dissolved in excess methylene chloride and dried (MgS04). After removal of solvent, the residue was purified by chromatography on silica gel to afford the title compound (1.9 g). ¹H NMR (CDCI3) No. 8.31 (s, 1 H), 7.73 (s,lH), 7.45-7.6 (m, 4H), 7.31 (s,lH), 1.84 (s,lH).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 871239-17-7.

Reference:
Patent; E.I. DUPONT DE NEMOURS AND COMPANY; WO2005/118552; (2005); A2;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 871239-17-7, name is 3-Bromo-1-(2-chlorophenyl)-1H-pyrazole-5-carboxylic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C10H6BrClN2O2

EXAMPLE 3; Preparation of 3-bromo-1- (2-chlorophenyl)-N-[2,4-dichloro carbonyl]phenyl]-1H-pyrazol-5-carboxamide; Step A: Preparation of 2-[3-bromo-1-(2-chlorophenyl)-1H-pyrazol-5-yl]-6,8-dichloro- 4H-3, 1 -benzoxazin-4-one; To a mixture of 3-bromo-1-(2-chlorophenyl)-lH-pyrazole-5-carboxylic acid (i. e. the carboxylic acid product of Example 1, Step E) (3.0 g, 9.44 mmol) and 3,5-dichloroanthranilic acid (1.94 g, 9.44 mmol) in acetonitrile (60 mL) was added 3-picoline (4.81 mL, 49.1 mmol) at room temperature, and the reaction mixture was stirred for 5 minutes. The reaction mixture was cooled to -10 C and methanesulfonyl chloride (1.91 mL, 24.56 mmol) in acetonitrile (5 mL) was added dropwise. The reaction mixture was warmed to room temperature and stirred overnight. The resulting solids were isolated by filtration, washed with water, then dissolved in excess methylene chloride and dried (MgS04). The solvent was evaporated under reduced pressure, and the residual solid was purified by chromatography on silica gel to afford the title compound (2.0 g). 1H NMR (CDC13) No. 8.0 (s, 1H), 7.72 (s, 1H), 7.4-7.55 (m, 4H), 7.28 (s, 1H)

The synthetic route of 871239-17-7 has been constantly updated, and we look forward to future research findings.