Category: 64781-79-9

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 64781-79-9, name is 4-Methyl-1H-pyrazol-3-amine, A new synthetic method of this compound is introduced below., Recommanded Product: 4-Methyl-1H-pyrazol-3-amine

EXAMPLE 28 3-Methyl-7-(3-thienyl)pyrazolo[1,5-a]pyrimidine A mixture of 0.01 mole of 3-dimethylamino-1-(3-thienyl)-2-propen-1-one and 0.01 mole of 3-amino-4-methylpyrazole in glacial acetic acid is heated at reflux temperature for 8 hours. The solvent is removed in vacuo to give the product of the example.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; American Cyanamid Company; US4281000; (1981); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

64781-79-9, name is 4-Methyl-1H-pyrazol-3-amine, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C4H7N3

(A) A 8.06 g portion of 3-amino-4-methyl-1H-pyrazole was dissolved in 30 ml of acetonitrile and, with cooling on an ice bath, 12.9 g of ethyl propionimidate hydrochloride was added to the solution. The resulting mixture was stirred for 1 hour at the same temperature and then overnight at room temperature. After removing insoluble materials by filtration, the resulting filtrate was concentrated under a reduced pressure, and the thus obtained residue was subjected to silica gel column chromatography. Elution with methanol-chloroform (1:9-3:7, v/v) gave 8.40 g of N-(4-methyl-1H-pyrazol-3-yl)propionamidine hydrochloride.

The synthetic route of 64781-79-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Yamanouchi Pharmaceutical Co., Ltd.; US5475114; (1995); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthetic Route of 64781-79-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 64781-79-9, name is 4-Methyl-1H-pyrazol-3-amine, This compound has unique chemical properties. The synthetic route is as follows.

Compound 6 (40 mmol) was dissolved in DMF (100 mL), then 4-methyl-2-aminopyrazole(44 mmol), sodium iodide (48 mmol) and diisopropylethylamine (DIPEA) (48 mmol). the solution was heated to 100 deg.] C, overnight,then cooled to room temperature, diluted with ethyl acetate (200 mL), saturated sodium bicarbonate solution (3 ¡Á 200mL), dried and reducedpressure concentrated and purified by flash chromatography on silica gel, washing wherein release agent, 0% to 4% methanol / dichloromethane to give a white-basedcolor solid 10- (sec-butyl) -5 – ((4-methyl -1H- pyrazol-3-yl) amino) -7 – oxo -2,3,7,10- tetrahydro – [1,4]dioxin [2], 3-H] quinoline-8-carboxylate, 15.09g, yield 91.5%,

The chemical industry reduces the impact on the environment during synthesis 4-Methyl-1H-pyrazol-3-amine. I believe this compound will play a more active role in future production and life.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 64781-79-9, name is 4-Methyl-1H-pyrazol-3-amine, A new synthetic method of this compound is introduced below., Recommanded Product: 4-Methyl-1H-pyrazol-3-amine

EXAMPLE 3 3-Methyl-7-(3-pyridyl)pyrazolo[1,5-a]pyrimidine As for Example 2, 3-amino-4-methylpyrazole is heated at reflux temperature for 6 hours with 3-dimethylamino-1-(3-pyridyl)-2-propen-1-one in glacial acetic acid to give the product of the example.

The synthetic route of 64781-79-9 has been constantly updated, and we look forward to future research findings.