Category: 10199-57-2

Application of 10199-57-2, These common heterocyclic compound, 10199-57-2, name is 5-Methyl-1-phenyl-1H-pyrazole-3-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 74 Production of N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-5-methyl-1-phenyl-1H-pyrazole-3-carboxamide Using 5-methyl-1-phenyl-1H-pyrazole-3-carboxylic acid (196 mg, 0.97 mmol), tetrahydrofuran (2.0 mL), N,N-dimethylformamide (30 muL, 0.39 mmol), oxalyl chloride (85 muL, 0.97 mmol), N-[6-(4-aminophenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide (200 mg, 0.65 mmol) and N,N-dimethylacetamide (4.0 mL), and in the same manner as in Example 255, the title compound (223 mg, 70%) was obtained as a white powder. 1H-NMR (DMSO-d6, 300 MHz) delta 0.76-0.83 (4H, m), 1.86-1.96 (1H, m), 2.31 (3H, s), 6.85 (1H, s), 7.02 (1H, d, J=9.6 Hz), 7.23 (2H, d, J=9.3 Hz), 7.36-7.46 (5H, m), 7.71 (2H, J=9.3 Hz), 7.92 (1H, s), 8.01 (1H, d, J=9.6 Hz), 10.62 (1H, s), 11.05 (1H, s).

Statistics shows that 5-Methyl-1-phenyl-1H-pyrazole-3-carboxylic acid is playing an increasingly important role. we look forward to future research findings about 10199-57-2.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; US2009/137595; (2009); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Related Products of 10199-57-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 10199-57-2, name is 5-Methyl-1-phenyl-1H-pyrazole-3-carboxylic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: Compounds 19a,b were refluxed for 5 h with 15 mL of thionylchloride. After this time, the mixture was evaporated underreduced pressure to give the appropriate chlorides 20a,b that wereused crude for the next reaction.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Methyl-1-phenyl-1H-pyrazole-3-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Cascioferro, Stella; Maggio, Benedetta; Raffa, Demetrio; Raimondi, Maria Valeria; Cusimano, Maria Grazia; Schillaci, Domenico; Manachini, Barbara; Plescia, Fabiana; Daidone, Giuseppe; European Journal of Medicinal Chemistry; vol. 123; (2016); p. 58 – 68;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

10199-57-2, name is 5-Methyl-1-phenyl-1H-pyrazole-3-carboxylic acid, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 5-Methyl-1-phenyl-1H-pyrazole-3-carboxylic acid

General procedure: EDCI (1.1 equiv.) and HOBt (1.1 equiv) were added to a solution of the intermediate acid compound 1a-j (1 equiv.) in anhydrous DMF. The reaction mixture was stirred for 1h at ambient temperature, and the L-serine ester (1.1 equiv.) and DIEA (3 equiv.) were added. The solution was heated to 70C for 6h and then cooled to room temperature. The reaction mixture was poured into ice water, and the resulting solid was filtered and dried to give the desired compound.

The synthetic route of 10199-57-2 has been constantly updated, and we look forward to future research findings.