Category: 57012-20-1

Adding a certain compound to certain chemical reactions, such as: 57012-20-1, name is (1,3-Dimethyl-1H-pyrazol-5-yl)methanol, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 57012-20-1, Quality Control of (1,3-Dimethyl-1H-pyrazol-5-yl)methanol

To a stirring solution of (2,5-dimethyl-2H-pyrazol-3-yl)-methanol (100 mg, 0.79 mmol) in diethyl ether (3 ml.) is added PBr3 (25 //L, 0.26 mmol). The reaction is stirred at room temperature for 18 hours, then water is added. The diethyl ether layer is separated and stored over solid NaOH and used in Step 71b without further characterization.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (1,3-Dimethyl-1H-pyrazol-5-yl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2007/68418; (2007); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 57012-20-1, name is (1,3-Dimethyl-1H-pyrazol-5-yl)methanol belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C6H10N2O

2-((l,3-dimethyl-lH-pyrazol-5-yl)methoxy)-5-fluoronicotinic acid (21x)To a solution of 2-chloro-5-fluoronicotinic acid (1.0g, 5.7mmol) in THF (20ml) under a N2 atmosphere was added (l,3-dimethyl-lH-pyrazol-5-yl)methanol (l .Og, 8.0mmol) followed by a portion-wise addition of NaH (60% dispersion in mineral oil, 0.68g, 17mmol). The resulting suspension was stirred at 70C for 16h and then cooled to room temperature and quenched with 1M NaOH (15ml). After washing with DCM (x2), the aqueous layer was acidified with concentrated HC1 until the product precipitated out of solution (~ pH 5). The solids were filtered, washed with ¾0 and then dried under high vacuum to afford the title compound(1.34g, 89%) as a white solid.NMR delta 8.37 (1H, d, J 3.1), 8.02 (1H, dd, J 8.2, 3.1), 6.10 (1H, s), 5.36 (2H, s), 3.75 (3H, s), 2.08 (3H, s);MS (m/e) 266 [M+H]+, Rt 0.71min (QC Method 1)

The synthetic route of 57012-20-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ARROW THERAPEUTICS LIMITED; ASTRAZENECA UK LIMITED; BARNES, Michael, Christopher, Stratton; FLACK, Stephen, Sean; FRASER, Ian; LUMLEY, James, Andrew; PANG, Pui Shan; SPENCER, Keith, Charles; TIBERGHIEN, Nathalie, Anne, Laure; TOMKINSON, Gary, Peter; WO2011/151651; (2011); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Reference of 57012-20-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 57012-20-1, name is (1,3-Dimethyl-1H-pyrazol-5-yl)methanol belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Dissolve ETHYL-3-METHYLPYRAZOLE-5-CARBOXYLATE (1.0893 g, 7.07 mmol) in 10 mL tetrahydrofuran and add it dropwise to a suspension OF SODIUM HYDRIDE (60%) (377. 6 mg, 9.44 mmol) in 10 mL tetrahydrofuran. After 2 hours, quench the reaction with methyl iodide (excess) and stir for an additional 2 hours. Add water to the reaction and remove the tetrahydrofuran in vacuo. Partition the residue between ethyl acetate and brine. Dry the organic layer with magnesium sulfate. Filter and remove the solvent in VACUO to afford 950. 0 mg of crude 2,5-dimethyl-2H-pyrazole-3-carboxylic acid ethyl ester. Dissolve this material (950.0 mg, 5.65 mmol) in 10 mL tetrahydrofuran and add it dropwise to a slurry of lithium alumininum hydride (220.2 mg) in 20 mL tetrahydrofuran at 0 C. After 30 minutes at this temperature, heat the reaction to reflux for 2 hours. Cool the reaction to room temperature and add 20 mL ethyl acetate to the reaction. Add 5N sodium hydroxide to the reaction until a white precipitate appears. Filter the reaction and concentrate the filtrate in vacuo. Partition the residue between ethyl acetate and water. Dry the organic layer with magnesium sulfate. Filter and remove the solvent in vacuo to afford 493.7 mg of crude (2, 5-DIMETHYL-2H-PYRAZOL-3-YL)-METHANOL. Dissolve this crude material (493.7 mg, 3.91 mmol) in 20 mL methylene chloride and add MN02 (1.2939 g, 14.88 mmol) to the reaction mixture. Heat the reaction mixture to reflux and allow it to stir for 16 hours. Cool the reaction and filter it through a pad of celite. Concentrate the filtrate in W . CO to afford 444.5 mg of crude product. Purify via Biotage chromatography (25% ethyl acetate/Hexanes) to afford 138.7 mg of the title compound’H NMR (CDCL3) 8 9. 81 (1 H, s), 6.46 (1 H, s), 3.82 (3 H, s), 2.24 (3 H, S).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (1,3-Dimethyl-1H-pyrazol-5-yl)methanol, other downstream synthetic routes, hurry up and to see.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 57012-20-1 as follows. Recommanded Product: 57012-20-1

Example 253; 4-{1-[(1,3-dimethyl-1H-pyrazol-5-yl)methyl]-3,5-dimethyl-1H-pyrazol-4-yl}benzonitrile A resin reagent (PS-triphenylphosphine) (about 220 mg) was charged in a polypropylene tube equipped with a filter ?cap, and preconditioned therein. Then, a solution (0.42 mol/L, 0.643 mL) of (1,3-dimethyl-1H-pyrazol-5-yl)methanol in THF and a solution (0.28 mol/L, 0.643 mL) of 2-chloro-4-(3,5-dimethyl-1H-pyrazol-4-yl)benzonitrile synthesized in Reference Example in THF were added and the mixture was stirred. A solution (0.70 mol/L, 0.643 mL) of di-tert-butyl azodicarboxylate in THF was added and the mixture was stirred at room temperature for 24 hr. The resin reagent was removed by filtering and washing the reaction mixture. The filtrate was concentrated. The residue was applied to reversed-phase preparative HPLC (Gilson, UniPoint system, YMC ODS column 30¡Á75 mm, 0.1% TFA containing acetonitrile-water (5:95-100:0)) and the eluted fraction was concentrated under reduced pressure, and obtained residue was further purified by silica gel column chromatography (50-100% ethyl acetate/hexane) to give the title compound (17.8 mg).MS (ESI+, m/e) 306 (M+1)1H-NMR (DMSO-d6) delta: 2.07 (3H, s), 2.16 (3H, s), 2.29 (3H, s), 3.79 (3H, s), 5.32 (2H, s), 5.87 (1H, s), 7.49 (2H, d), 7.86 (2H, d).

According to the analysis of related databases, 57012-20-1, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 57012-20-1, name is (1,3-Dimethyl-1H-pyrazol-5-yl)methanol, This compound has unique chemical properties. The synthetic route is as follows., Formula: C6H10N2O

Example 1.2: Preparation of 2,5-dimethyl-2H-pyrazole-3-carbaldehyde1.3 g of oxalic acid chloride in 40 ml DCM were cooled to -700C and 1 ,6 g DMSO in 10 ml DCM were added dropwise. After 5 min of stirring at -700C 1 g of (2,5-dimethyl- 2H-pyrazol-3-yl)-methanol (example 1.1 ) in 10 ml DCM and 6 g triethylamine were added and the reaction mixture was allowed to warm to about 20 to 25C. After extrac- tion with water the reaction mixture was dried. After removing the solvents in vacuo, the resulting residue was purified by column chromatography over silica with cyclohex- ane/ethylacetate mixtures yielding 0.6 g of the title compound as a yellowish oil. 1H-NMR (CDCI3, delta in ppm): 9.8 (s, 1 H); 6.7 (s, 1 H); 4.1 (s, 3H); 2.3 (s, 3H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 57012-20-1.

Some common heterocyclic compound, 57012-20-1, name is (1,3-Dimethyl-1H-pyrazol-5-yl)methanol, molecular formula is C6H10N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of (1,3-Dimethyl-1H-pyrazol-5-yl)methanol

71 a) To a stirring solution of (2,5-dimethyl-2H-pyrazol-3-yl)-methanol (100 mg, 0.79 mmol) in diethyl ether (3 mL) is added PBr3 (25 muL, 0.26 mmol). The reaction is stirred at room temperature for 18 hours, then water is added. The diethyl ether layer is separated and stored over solid NaOH and used in Step 71 b without further characterization. 71b) BEMP (137 pL, 0.47 mmol) is added to a solution of (2-methyl-1H-pyrrolo[2,3- b]pyridin-3-yl)-acetic acid methyl ester (60 mg, 0.29 mmol) in DMF (0.8 mL). After 35 minutes, the diethyl ether layer from Step 71 a (1.8 mL) is added. After 3 days, the reaction is partitioned between water and 1:1 EtOAc/ether. The organic layer is washed with brine then evaporated. The residue is purified by flash column chromatography (49:1 EtOAc/MeOH elution) to furnish [1-(2,5-dimethyl-2H-pyrazol-3-ylmethyl)-2-methyl-1H- pyrrolo[2,3-b]pyridin-3-yl]-acetic acid methyl ester; MH+ = 313.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 57012-20-1, its application will become more common.

Related Products of 57012-20-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 57012-20-1, name is (1,3-Dimethyl-1H-pyrazol-5-yl)methanol, This compound has unique chemical properties. The synthetic route is as follows.

Step 2: Preparation of 2,5-dimethyl-2H-pyrazole-3-carbaldehyde (15) A mixture of compound 14 (3 grams, 23.8 mmol) and pyridinium dichromate (13.4 grams, 35.7 mmol) in dichloromethane (100 mL) was stirred at 25 C. under nitrogen atmosphere for 16 hours. The reaction mixture was then filtered. The filtrate was collected, dried over anhydrous Na2SO4 and concentrated under reduced pressure. The crude thus obtained was passed through the silica gel to afford the desired compound 2,5-dimethyl-2H-pyrazole-3-carbaldehyde (15) 1 gram as a brown solid. Yield: 34%; 1H NMR (200 MHz, CDCl3): delta 9.8 (s, H), 6.6(s, H), 4.1 (s, 3H), 2.3 (s, 3H). Mass (CI method, i-butane): 125 (M+1, 100%); IR: numax (KBr, cm-1): 1688.

The chemical industry reduces the impact on the environment during synthesis (1,3-Dimethyl-1H-pyrazol-5-yl)methanol. I believe this compound will play a more active role in future production and life.