Category: 1191616-45-1

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1191616-45-1, name is 4-(4-Bromophenyl)-1-methyl-1H-pyrazole, A new synthetic method of this compound is introduced below., COA of Formula: C10H9BrN2

Into a 500-mL 3-necked round-bottom flask, were placed 4-(4-bromophenyl)- 1-methyl-1H-pyrazole (3.80 g, 16.0 mmol) and tetrahydrofuran (50 mL). This was followed by the addition of n-BuLi (7.00 mL, 74.3 mmol) dropwise with stirring at -80 C within 5 min. To this was added 1-benzyl-5-bromo-N- methoxy-N-methyl-1 H-indazole-3-carboxamide (2.00 g, 5.34 mmol, synthesis see below). The resulting solution was stirred for 150 min at -80 C. The reaction was then quenched by the addition of 50 mL of ice water. The resulting solution was extracted twice with 50 mL of ethyl acetate and the organic layers combined and dried over anhydrous sodium sulfate and concentrated under vacuo. The residue was applied onto a silica gel column with dichloromethane/methanol (100/1). This resulted in 1.70 g (60%) of 5- bromo-3-[[4-(1-methyl-1 H-pyrazol-4-yl)phenyl]carbonyl]-1-(1-phenylpentyl)- 1 H-indazole as a yellow solid.

The synthetic route of 1191616-45-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK PATENT GMBH; CANCER RESEARCH TECHNOLOGY LTD.; SCHIEMANN, Kai; (173 pag.)WO2016/41618; (2016); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1191616-45-1, name is 4-(4-Bromophenyl)-1-methyl-1H-pyrazole, A new synthetic method of this compound is introduced below., SDS of cas: 1191616-45-1

Compound 6c (1.5g, 5.0mmol), 4-(4-bromophenyl)-1-methyl-1H-pyrazole (1.2g, 5.0mmol), catalyst Pd(dba) 2 (144mg, 0.25mmol) , Tri-tert-butylphosphine (101mg, 0.5mmol), sodium tert-butoxide (576mg, 6.0mmol) were dissolved in toluene (50ml), heated to 100 and stirred for 12 hours, TLC detection reaction, direct concentration column chromatography separation 1.6 g of off-white solid was obtained with a yield of 69.3%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 1191616-45-1, The chemical industry reduces the impact on the environment during synthesis 1191616-45-1, name is 4-(4-Bromophenyl)-1-methyl-1H-pyrazole, I believe this compound will play a more active role in future production and life.

Compound 11c (1.4g, 5.0mmol),1-(4-Bromophenyl)-1-methyl-1H-pyrazole(1.2g, 5.0mmol), catalyst Pd(dba)2 (144mg, 0.25mmol), tri-tert-butylphosphine (101mg, 0.5mmol), sodium tert-butoxide (576mg, 6.0mmol) were dissolved in toluene (50ml) The temperature was raised to 100C and the reaction was stirred for 12 hours. The reaction was detected by TLC, and directly concentrated by column chromatography to obtain 1.4g of off-white solid with a yield of 63.1%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-(4-Bromophenyl)-1-methyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.