Category: 1254717-53-7

Electric Literature of 1254717-53-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1254717-53-7 name is (5-(Trifluoromethyl)-1H-pyrazol-3-yl)methanamine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(3-(Trifluoromethyl)-1 H-pyrazol-5-yl)methanamine (0.7 g, 4.2 mmol, 1 eq) was charged in dichloromethane (70 ml) at room temperature, then to that TEA (.42g, 4.2 mmol, 1eq ) was added at room temperature and stirred for 10 min and cooled to 0-5C. (Boc)20 (0.92 g, 4.2 mmol, 1 eq) was added drop wise to reaction mixture for 30 min and maintained for 3 h at 0-5C. Progress of the reaction was monitored by the TLC (30 % Ethyl acetate/Hexane). On completion of the reaction, dichloromethane was distilled, the residue obtained was treated water (50 ml) and extracted with ethyl acetate (100 ml). The combined organic layer was dried over sodium sulphate, distilled the solvent under vacuum. The obtained crude was purified with column chromatography to yield the required product as a white colored solid (0.5 g, 44 % yield).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, (5-(Trifluoromethyl)-1H-pyrazol-3-yl)methanamine, and friends who are interested can also refer to it.

Reference:
Patent; GRUeNENTHAL GMBH; FRANK, Robert; CHRISTOPH, Thomas; LESCH, Bernhard; LEE, Jeewoo; WO2012/62462; (2012); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Some common heterocyclic compound, 1254717-53-7, name is (5-(Trifluoromethyl)-1H-pyrazol-3-yl)methanamine, molecular formula is C5H6F3N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: (5-(Trifluoromethyl)-1H-pyrazol-3-yl)methanamine

Step 11 :To a stirred solution of compound 11 (2.8 g, 13.9 mmol) in DCM (76 mL) was added TEA (7 mL, 41 .7mmol, 3.0 eq) followed by phenyl 3-fluoro-4-(hydroxymethyl)phenyl-carbamate (3.63 g, 31 .9mmol, 1 .0 eq.) (synthesis described for in example A58) at room temperature and the mixture was stirred for 16 h. After completion of the reaction, a solid precipitate was filtered and washed with DCM (2 mL) followed by n-pentane (5 mL) and dried to get 12 (3.38 g, 73 %).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1254717-53-7, its application will become more common.

Reference:
Patent; GRUeNENTHAL GMBH; FRANK, Robert; CHRISTOPH, Thomas; SCHIENE, Klaus; DE VRY, Jean; DAMANN, Nils; LESCH, Bernhard; BAHRENBERG, Gregor; SAUNDERS, Derek John; STOCKHAUSEN, Hannelore; KIM, Yong-Soo; KIM, Myeong-Seop; LEE, Jeewoo; WO2013/68461; (2013); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Reference of 1254717-53-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1254717-53-7 name is (5-(Trifluoromethyl)-1H-pyrazol-3-yl)methanamine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(3-(Trifluoromethyl)-1 H-pyrazol-5-yl)methanamine (0.7 g, 4.2 mmol, 1 eq) was charged in dichloromethane (70 ml) at room temperature, then to that TEA (.42g, 4.2 mmol, 1eq ) was added at room temperature and stirred for 10 min and cooled to 0-5C. (Boc)20 (0.92 g, 4.2 mmol, 1 eq) was added drop wise to reaction mixture for 30 min and maintained for 3 h at 0-5C. Progress of the reaction was monitored by the TLC (30 % Ethyl acetate/Hexane). On completion of the reaction, dichloromethane was distilled, the residue obtained was treated water (50 ml) and extracted with ethyl acetate (100 ml). The combined organic layer was dried over sodium sulphate, distilled the solvent under vacuum. The obtained crude was purified with column chromatography to yield the required product as a white colored solid (0.5 g, 44 % yield).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, (5-(Trifluoromethyl)-1H-pyrazol-3-yl)methanamine, and friends who are interested can also refer to it.

Reference:
Patent; GRUeNENTHAL GMBH; FRANK, Robert; CHRISTOPH, Thomas; LESCH, Bernhard; LEE, Jeewoo; WO2012/62462; (2012); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application of 1254717-53-7, The chemical industry reduces the impact on the environment during synthesis 1254717-53-7, name is (5-(Trifluoromethyl)-1H-pyrazol-3-yl)methanamine, I believe this compound will play a more active role in future production and life.

(3-(Trifluoromethyl)-1 H-pyrazol-5-yl)methanamine (7 g, 42.4 mmol) was dissolved in DCM (7 mL) at room temperature, then to that TEA (5.86 mL, 72.4 mmol ) was added at room temperature and the mixture was stirred for 10 min and cooled to 0-5 ‘C. (Boc)20 (9.24 g, 42.4 mmol) was added drop wise to reaction mixture for 30 min and maintained for 3 h at 0-5 C. Progress of the reaction was monitored by the TLC (30 % ethyl acetate/n-hexane). On completion of the reaction, the reaction mixture was brought to room temperature for 2 h and the DCM was distilled off, the residue obtained was treated with water (50 mL) and extracted with ethyl acetate (100 mL). The combined organic layer was dried over sodium sulphate, and the solvent evaporated under vacuum. The obtained crude was purified with CC to yield tert-butyl (3-(trifluoromethyl)-1 H-pyrazol-5-yl)methylcarbamate as a white colored solid (5 g, 44 %).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (5-(Trifluoromethyl)-1H-pyrazol-3-yl)methanamine, other downstream synthetic routes, hurry up and to see.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1254717-53-7, name is (5-(Trifluoromethyl)-1H-pyrazol-3-yl)methanamine, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: (5-(Trifluoromethyl)-1H-pyrazol-3-yl)methanamine

Step i: (3-(Trifluoromethyl)-1H-pyrazol-5-yl)methanamine (0.7 g, 4.2 mmol, 1 eq) was charged in dichloromethane (70 ml) at room temperature, then to that TEA (0.42 g, 4.2 mmol, 1 eq) was added at room temperature and stirred for 10 min and cooled to 0-5 C. (Boc)2O (0.92 g, 4.2 mmol, 1 eq) was added drop wise to reaction mixture for 30 min and maintained for 3 h at 0-5 C. Progress of the reaction was monitored by the TLC (30% Ethyl acetate/Hexane). On completion of the reaction, dichloromethane was distilled, the residue obtained was treated water (50 ml) and extracted with ethyl acetate (100 ml). The combined organic layer was dried over sodium sulphate, distilled the solvent under vacuum. The obtained crude was purified with column chromatography to yield the required product as a white colored solid (0.5 g, 44% yield).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1254717-53-7.