Category: 10250-63-2

Adding a certain compound to certain chemical reactions, such as: 10250-63-2, name is Ethyl 1-methyl-3-phenyl-1H-pyrazole-5-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10250-63-2, Application In Synthesis of Ethyl 1-methyl-3-phenyl-1H-pyrazole-5-carboxylate

Production Example 197c) 0.12 g of ethyl 1-methyl-3-phenyl-1H-5-pyrazolecarboxylate was dissolved in 5 ml ethanol. 1 ml of 5N aqueous sodium hydroxide solution was added thereto, followed by heating under reflux for 1 hour. The reaction solution was ice-cooled, neutralized with 2N hydrochloric acid and then extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous magnesium sulfate and evaporated, to give 0.11 g of 1-methyl-3-phenyl-1H-5-pyrazolecarboxylic acid. 1H-NMR(CDCl3) delta: 4.22(s, 3H) 7.22(s, 1H) 7.33(t, J=8.0Hz, 1H) 7.40(t, J=8.0Hz, 2H) 8.80(d, J=8.0Hz, 2H)

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Reference:
Patent; Eisai Co., Ltd.; EP1216980; (2002); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application of 10250-63-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 10250-63-2, name is Ethyl 1-methyl-3-phenyl-1H-pyrazole-5-carboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Production Example 197c) 0.12 g of ethyl 1-methyl-3-phenyl-1H-5-pyrazolecarboxylate was dissolved in 5 ml ethanol. 1 ml of 5N aqueous sodium hydroxide solution was added thereto, followed by heating under reflux for 1 hour. The reaction solution was ice-cooled, neutralized with 2N hydrochloric acid and then extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous magnesium sulfate and evaporated, to give 0.11 g of 1-methyl-3-phenyl-1H-5-pyrazolecarboxylic acid. 1H-NMR(CDCl3) delta: 4.22(s, 3H) 7.22(s, 1H) 7.33(t, J=8.0Hz, 1H) 7.40(t, J=8.0Hz, 2H) 8.80(d, J=8.0Hz, 2H)

The synthetic route of Ethyl 1-methyl-3-phenyl-1H-pyrazole-5-carboxylate has been constantly updated, and we look forward to future research findings.

Synthetic Route of 10250-63-2, These common heterocyclic compound, 10250-63-2, name is Ethyl 1-methyl-3-phenyl-1H-pyrazole-5-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of ester [[10250-63-2]] (1.7 g, 7.4 mmol) and aqueous 1 M KOH (10 mmol) in [ETOH] (20 mL) is stirred for 6 h. The reaction mixture is concentrated, and the residue is partitioned between cold aqueous 1 M HCl and EtOAc. The EtOAc solution is separated. The aqueous solution is further extracted with EtOAc. The combined EtOAc extracts are dried and concentrated to give [10250-64-3] as a powder: MS (ESI-) m/z 185.5.

Statistics shows that Ethyl 1-methyl-3-phenyl-1H-pyrazole-5-carboxylate is playing an increasingly important role. we look forward to future research findings about 10250-63-2.