Category: 13788-84-6

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13788-84-6, name is 3-Methyl-4-phenyl-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., category: pyrazoles-derivatives

Example 4(2R)-N-hvdroxy-2-methyl-4-(3-methyl-4-phenyl-1 H-pyrazol-1-yl)-2-Step A: ethyl (2R)-2-methyl-4-(3-methyl-4-phenyl-1 H-pyrazol-1 -yl)-2-(methylsulfonvDbutanoateTo a solution of the 3-methyl-4-phenylpyrazole (400 mg, 2.53 mmol, 1 eq) in THF (25 mL) was added cesium carbonate (2.52 g, 7.70 mmol, 3 eq) and (R)-ethyl 4-bromo-2-methyl-2-(methylsulfonyl)butanoate (950 mg, 3.31 mmol, 1 .3 eq). The resulting suspension was heated to 70 C and stirred overnight. The reaction was filtered through celite, and the filter pad was washed with ethyl acetate (2x 100 mL). Combined filtrates were concentrated and the crude material was purified on a Analogix SF15-24g column using an eluant of ethyl acetate in heptane (0-80%) to give ethyl (2R)-2-methyl-4-(3-methyl-4-phenyl-1 H-pyrazol-1 -yl)-2- (methylsulfonyl)butanoate (178 mg, 19.3%). LC-MS M+H+ 365.1

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 13788-84-6.

Related Products of 13788-84-6, These common heterocyclic compound, 13788-84-6, name is 3-Methyl-4-phenyl-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a nitrogen-purged glove box, (oxybis(2,1-phenylene))bis(diphenylphosphine) (1.0 g, 1.85 mmol) and toluene (30 mL) were added to a glass jar, equipped with a PTFE-coated stir bar. While stirring, mesitylcopper(I) (0.31 g, 1.70 mmol) was added. After a few minutes, 3-methyl-4-phenyl-1H-pyrazole (0.30 g, 1.90) was added, and the resulting mixture was heated at 90C for 3 hours. The mixture was then cooled to 60C, and stirred overnight. After cooling to room temperature, the solid that had formed was collected by filtration. The isolated solid was rinsed with toluene, followed by hexanes, and dried at 70C, under vacuum, to afford the title compound (0.66 g). Crystals were grown by slow evaporation of dichloromethane, and characterized by single crystal X-Ray crystallography, supporting the above molecular structure.

The synthetic route of 13788-84-6 has been constantly updated, and we look forward to future research findings.