Category: 5334-41-8

Application of 5334-41-8, A common heterocyclic compound, 5334-41-8, name is 5-Amino-1-methyl-1H-pyrazole-4-carbonitrile, molecular formula is C5H6N4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 20 2-(Azetidin-1-yl)-4-difluoromethoxybenzooxazole-7-carboxylic acid (4-cyano-2-methyl-2H-pyrazol-3-yl)-amide Starting from 2-(azetidin-1-yl)-4-difluoromethoxybenzooxazole-7-carboxylic acid 4-nitro-phenyl ester (178 mg) and 5-amino-1-methyl-1H-pyrazole-4-carbonitrile (107 mg). Purification by column chromatography on silica eluding with 3% methanol in dichloromethane followed by trituration in diethyl ether afforded the title compound as a white solid (124 mg). TLC Rf 0.31 (ethyl acetate). M.p. 247-248 C.

The synthetic route of 5334-41-8 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5334-41-8, name is 5-Amino-1-methyl-1H-pyrazole-4-carbonitrile belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 5-Amino-1-methyl-1H-pyrazole-4-carbonitrile

Alternatively, a mixture of 5 -amino- 1 -methyl- lH-pyrazolo 4-carbonitrile 2 (3.00 g, 24.59 mmol), IM aqueous solution of sodium hydroxide (1.1 equiv., 27 ml) and -30% aqueous solution of hydrogen peroxide (5 equiv., 14 ml) were stirred in methanol (30 ml) at room temperature overnight. The volume of reaction mixture was reduced in vacuo, precipitate filtered and dried to give 5 -amino- 1 -methyl- lH-pyrazolo-4-carboxylic acid amide 3 (2.99 g, 87 %).

The synthetic route of 5334-41-8 has been constantly updated, and we look forward to future research findings.

5334-41-8, name is 5-Amino-1-methyl-1H-pyrazole-4-carbonitrile, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C5H6N4

Example 1.1.: 5-amino-1-methyl-1H-pyrazole-4-carboxamide (2) 12.2 g (100 mmol) of 5-amino-1-methyl-1H-pyrazole-4-carbonitrile, 1 (Commercial supplier: BIONET-INTER) are dissolved in 50 mL of conc. sulfuric acid and stirred at RT for 3 h. The reaction mixture is cooled to 0-5 C and neutralized at that temperature by addition of aqueous ammonia. The water phase is extracted with chloroform, the solvent is evaporated and the residue crystallized from water to yield the title compound.

The synthetic route of 5334-41-8 has been constantly updated, and we look forward to future research findings.