Category: 5775-82-6

Electric Literature of 5775-82-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5775-82-6, name is 4-Bromo-1,3-dimethyl-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Preparation 75: 4-(1 ,3-dimethyl-1 -/-pyrazol-4-yl)-2-methoxyaniline A suspension of 2-methoxy-4-(4,4,5,5-tetramethy-1 ,3,2-dioxaborolan-2-yl)aniline (50 mg, 0.201 mmol), 4-bromo-1 ,3-methylpyrazole (35 mg, 0.201 mmol), CsF (91 mg, 0.602 mmol) and Pd(PPh3)4 (12 mg, 10.04 umol) in DME/MeOH (2:1 , 1 .5 mL) was heated to 150 Patent; CANCER RESEARCH TECHNOLOGY LIMITED; HOELDER, Swen; BLAGG, Julian; SOLANKI, Savade; WOODWARD, Hannah; NAUD, Sebastian; BAVETSIAS, Vassilios; SHELDRAKE, Peter; INNOCENTI, Paolo; CHEUNG, Jack; ATRASH, Butrus; WO2014/37750; (2014); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5775-82-6 as follows. name: 4-Bromo-1,3-dimethyl-1H-pyrazole

To a suspension of 4-bromo-l,3-dimethyl-pyrazole (5.00 g, 28.60 mmol) in anhydrous 1,4-dioxane (100.0 mL) were added 4,4,4′,4′,5,5,5′,5l-octamethyl-2,2′-bi(l,3,2-dioxaborolane) (8.71 g, 34.32 mmol), acetoxy potassium (5.63 g, 57.41 mmol) and Pd(dppf)2Cl2 dichloromethane complex (2.38 g, 2.86 mmol). The mixture was degassed and refilled with nitrogen for several times and then heated to 100 C and stirred overnight. The mixture was concentrated in vacuo. The residue was diluted with water (30 mL), and the resulting mixture was extracted with EtOAc (50 mLchi3). The combined organic layers was dried over anhydrous Na2S04, filtered and concentrated in vacuo. The residue was purified by silica chromatography (EtOAc/PE (v/v) = 1/20 to 1/8) to afford the title compound as brown sticky liquid (3.80 g, yield 60%).MS (ESI, pos. ion) m/z: 223.3 [M+H]+

According to the analysis of related databases, 5775-82-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; CALITOR SCIENCES, LLC; XI, Ning; LI, Xiaobo; LI, Mingxiong; ZHANG, Tao; HU, Haiyang; WU, Yanjun; (139 pag.)WO2018/169700; (2018); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 5775-82-6, name is 4-Bromo-1,3-dimethyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5775-82-6, category: pyrazoles-derivatives

0142-1 2,2′-Azobis(isobutyronitrile) (27 mg) was added to a solution of 4-bromo-1,3-dimethyl-1H-pyrazole (286 mg) and N-bromosuccinimide (320 mg) in chlorobenzene (6 mL), followed by stirring at 80 C. for 7 hours. The reaction mixture was cooled to room temperature, and ethyl acetate and a saturated sodium hydrogen carbonate aqueous solution were added thereto. The organic layer was collected by separation, washed with a saturated sodium chloride aqueous solution, and dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure, thereby obtaining 4-bromo-3-(bromomethyl)-1-methyl-1H-pyrazole (465 mg) as a white solid. MS m/z (M+H): 253.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5775-82-6, name is 4-Bromo-1,3-dimethyl-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 4-Bromo-1,3-dimethyl-1H-pyrazole

Into a dry flask under N2 is added dry diethyl ether (150 mL) and 1 ,3-dimethyl-4- bromopyrazole (5g, 28.6 mmol, Combi-Blocks). The mixture is cooled to -78C in a dry ice/acetone bath. To this solution is added f-BuLi (37 mL, 62.9 mmol, 1.7 M in pentane) over 5 min, which is allowed to stir for 30 min at -78 C. 2-isopropoxy-4,4,5,5- tetramethyl-1 ,3,2-dioxaborolane (6.4 mL, 31.4 mmol) is added in one portion via syringe. Stirring is continued at -78 C for 15 min. The reaction mixture is allowed to warm to RT and is then stirred for 30 min. The reaction mixture is poured into saturated NH4CI, then extracted with EtOAc (3x). The combined organic layers are dried (Na2S04), filtered and evaporated under reduced pressure. The residue is dissolved in hexanes (6 mL). The solvent is evaporated under reduced pressure and then dried under high vacuum for 48 h to provide boronate ester 24a.

According to the analysis of related databases, 5775-82-6, the application of this compound in the production field has become more and more popular.