Category: 92534-69-5

Reference of 92534-69-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 92534-69-5 name is 1-Methyl-4-nitro-1H-pyrazole-5-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A solution of 1-methyl-4-nitro-1H-pyrazole-5-carboxylic acid (1.03 g, 6 mmol), EtBr (3 mL) and K2CO3 (1.66 g, 12 mmol) in DMF (30 mL) was stirred for 1 hour at 60 oC. Then it was poured into water and extracted with EA(3x) to give desired compound as a light yellow solid. (995 mg, 83 %). ESI-MS m/z: 200.2 [M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Methyl-4-nitro-1H-pyrazole-5-carboxylic acid, and friends who are interested can also refer to it.

Synthetic Route of 92534-69-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 92534-69-5 as follows.

A mixture of 2-methyl-4-nitro-2H-pyrazole-3-carboxylic acid (138.8 mmol) and thionyl chloride (300 mL) is heated under reflux for 12 h. The mixture is then concentrated to dryness under reduced pressure. The resulting oil is dissolved in acetone (200 mL) and it is added to cold aqueous ammonium hydroxide with stirring. The precipitate is collected by filtration and it is dried to give 2- methyl-4-nitro-2H-pyrazole-3-carboxylic acid amide as an off-white solid. Compound wt: 10.5g, 45% yield.[00253] 1H NMR (400 MHz, DMSO-^6) delta: 8.47 (IH, s); 8.32 (IH, s); 8.27 (IH, s); 3.86 (3H, s).

According to the analysis of related databases, 92534-69-5, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 92534-69-5, name is 1-Methyl-4-nitro-1H-pyrazole-5-carboxylic acid, A new synthetic method of this compound is introduced below., Quality Control of 1-Methyl-4-nitro-1H-pyrazole-5-carboxylic acid

1-Methyl-4-nitroimidazole-5-carboxylic acid (or 1-methyl-4-nitropyrazole-5-carboxylic acid) (0.51 g, 3 mM, dry tetrahydrofuran (90 mL) and triethylamine (0.6 mL) were cooled to -10C. A solution of ethyl chloroformate (0.36 mL) in dry tetrahydrofuran (10 mL) was added to the resulting mixture and was stirred for further 30 min. The mixture of 2-(6-methoxy-1-methyl-9H-carbazol-2-yl)ethylamine 5 (0.75 g, 3 mM), tetrahydrofuran (90 mL) and triethylamine (0.6 mL) was added dropwise at -10C. The resulting mixture was left for 24 h to reach room temperature with stirring and evaporation under reduced pressure afforded a residue which was put into water (100 mL), alkalized with sodium hydrogen carbonate, and extracted with methylene chloride. The extract was dried over magnesium sulfate. After evaporation of the solvent, the solid residue was purified by column chromatography on silica gel and eluted with chloroform : methanol (9 : 1).

The synthetic route of 92534-69-5 has been constantly updated, and we look forward to future research findings.