Category: 31108-57-3

Electric Literature of 31108-57-3, The chemical industry reduces the impact on the environment during synthesis 31108-57-3, name is 1H-Pyrazole-4-carbonitrile, I believe this compound will play a more active role in future production and life.

To a solution of IV-B8 (44 mg, 0.11 mmol) in acetone (2 mL) was added lH-pyrazole-4- carbonitrile (16 mg, 0.17 mmol) and K2C03 (48 mg, 0.34 mmol). After stirring at 25C for 12 h, the mixture was diluted with water (5 mL) and extracted with EtOAc (2 x 10 mL). The combined organic solution was washed with brine (5 mL), dried over anhydrous Na2S04, filtered and concentrated. The residue was purified by flash column (0-43% of EtOAc in PE) to give IV-B9 (22 mg, 49%) as a solid. (3084) 1HNMR (400 MHz, CDCl3) dH 7.86 (s, 1H), 7.81 (s, 1H), 5.08-5.02 (m, 1H), 4.94-4.87 (m, 1H), 2.63 (t, j= 8.8 Hz, 1H), 2.26-2.16 (m, 1H), 2.06-1.99 (m, 1H), 1.82-1.70 (m, 6H), 1.46- 1.17 (m, 15H), 0.91-0.83 (m, 2H), 0.65 (s, 3H). LC-ELSD/MS purity 99%, MS ESI calcd. for C24H33N302 [M+H]+396.2, found 396.2

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-Pyrazole-4-carbonitrile, other downstream synthetic routes, hurry up and to see.

Reference of 31108-57-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 31108-57-3, name is 1H-Pyrazole-4-carbonitrile, This compound has unique chemical properties. The synthetic route is as follows.

Compound D (140 mg, 0.27 mmol) was dissolved in DMF (5 ml), then sodium carbonate (50 mg, 0.54 mmol), 1H-pyrazole-4-carbonitrile (57 mg, 0.54 mmol) was added, and the reaction was carried out at 25 C for 4 hours. . Pour into 1N NaOH aqueous solution (20 ml), extract EA four times (30ml x 4), wash twice with 1N hydrochloric acid (30ml x 2), Dry over anhydrous sodium sulfate, After concentration, silica gel column chromatography gave 30 mg of a colorless oily viscous liquid 2-1. The yield was 26%.

The chemical industry reduces the impact on the environment during synthesis 1H-Pyrazole-4-carbonitrile. I believe this compound will play a more active role in future production and life.

Synthetic Route of 31108-57-3, A common heterocyclic compound, 31108-57-3, name is 1H-Pyrazole-4-carbonitrile, molecular formula is C4H3N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a mixture of ABl (100 mg, 0.235 mmol) and K2C03 (64.9 mg, 0.47 mmol) in acetone (5 mL) was added lH-pyrazole-4-carbonitrile (32.7 mg, 0.352 mmol) at 25C. The reaction mixture was stirred at the 25C for 16 h. Then saturated aqueous H20 (50 mL) was added .The mixture was extracted with EtOAc (3 x 50 mL). The combined organic solution was washed with brine (20 mL), dried over Na2S04 and concentrated in vacuum to give the crude product .The crude product was purified by flash column (0-30% of EtOAc in PE) to give Compound 66 (38 mg, 37%) as a solid. (0895) 1H NMR (400 MHz, CDC13) delta 7.86 (s, 1H), 7.81 (s, 1H), 5.00 (d, J = 16.0 Hz, 1H), 4.85 (d, J = 16.0 Hz, 1H), 2.71-2.68 (m, 1H), 2.18-2.09 (m, 1H), 1.98-1.96 (m, 1H), 1.65-1.53 (m, 2H), 1.52-1.50 (m, 5H), 1.37-1.14 (m, 14H), 0.97 (d, J= 8 Hz, 4H), 0.85-0.81 (m, 1H), 0.75 (s, 3H), 0.68 (s, 3H). (0896) LCMS Rt = 2.594 min in 4.0 min chromatography, 30-90AB_220&254.1cm, purity 100%, MS ESI calcd. for C27H38N3O [M+H-H20]+ 420, found 420.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 31108-57-3, name is 1H-Pyrazole-4-carbonitrile, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C4H3N3

To a solution of crude reactant SB-FF (50.7 mg, 0.122 mmol, theoretical amount) in anhydrous THF (1.5 mL) was added 4-cyanopyrazole (22.7 mg, 0.244 mmol) followed by potassium carbonate (33.7 mg, 0.244 mmol). The solution was stirred at 25 C overnight. Then the solution was diluted with ethyl acetate (100 mL). The resulting solution was washed with brine (2×50 mL), dried over magnesium sulfate and concentrated in vacuo. The crude product was purified by reverse phase prep-HPLC to afford desired product (14.2 mg, 0.0332 mmol, two steps overall yield=27%) as white solid. 1HNMR (400 MHz, CDC13) 5(ppm): 7.85 (s, 1H), 7.81 (s, 1H), 5.03- 4.87 (m, 2H), 4.62-4.50 (m, 1H), 2.63-2.62 (m, 1H), 2.30-2.20 (m, 1H), 2.05-1.95 (m, 2H), 1.90- 1.60 (m, 6H), 1.50-1.20 (m, 15H), 0.70 (s, 3H). 19FNMR (376 MHz, CDCI3) 5(ppm): -193.13. LCMS: rt = 2.13 mm, m/z = 428.0 [M+H]+

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 31108-57-3.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 31108-57-3, name is 1H-Pyrazole-4-carbonitrile, A new synthetic method of this compound is introduced below., Application In Synthesis of 1H-Pyrazole-4-carbonitrile

To a solution of II-D4a (180 mg, 0.4 mmol) in acetone (5 mL) were added K2C03 (116 mg, 0.8 mmol) and lH-pyrazole-4-carbonitrile (78.7 mg, 0.8 mmol) at 25C. The reaction mixture was stirred for 12 hours at 25C. The reaction mixture was added into saturated NH4Cl (30 mL) and the aqueous layer was extracted with EtOAc (3 x 20 mL). The combined organic layer was washed with saturated brine (50 mL), dried over anhydrous Na2S0 , filtered and concentrated to give product. The residue was purified by flash column (10-20% of EtOAc in PE) to afford the product. The product was purified by prep-HPLC to afford II-D5a (59.6 mg, 32%) as a solid. (2696) 1H NMR (400 MHz, CDCl3) dH 7.85 (s, 1H), 7.81 (s, 1H), 4.95 (dd, J= 18.0, 49.6 Hz, 2H), 2.59 (t, J= 8.8 Hz, 1H), 2.25-2.13 (m, 1H), 2.07-2.01 (m, 1H), 1.92-1.82 (m, 1H), 1.80-1.60 (m, 7H), 1.55-1.12 (m, 15H), 1.05-0.90 (m, 2H), 0.85-0.75 (m, 4H), 0.65 (s, 3H); ELSD purity, 99%; MS ESI calcd. for C27H40N3O2 [M+H]+ 438, found 438

The synthetic route of 31108-57-3 has been constantly updated, and we look forward to future research findings.

31108-57-3, name is 1H-Pyrazole-4-carbonitrile, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C4H3N3

Prepared according General Procedure E, Step 2 from compound Cll (60 mg, 0.14 mmol) and lH-pyrazole-4-carbonitrile (63 mg, 0.67 mmol), with purification by column chromatography on silica gel to provide compound 27 as an off-white solid (27.3 mg, 44%): mp 176-178 C; 1HNMR (300 MHz, CDCI3) delta 7.83 (d, J = 12.3 Hz, 2H), 4.95 (q, J = 18.3 Hz, 2H), 3.53 (d, J = 9.0 Hz, IH), 3.33 (s, 3H), 3.22 (d, J = 9.0 Hz, IH), 2.59 (t, J = 9.3 Hz, IH), 2.26-1.35 (m, 17H), 1.31-1.08 (m, 9H), 0.66 (s, 3H) ppm; ESI MS m/z 437 [M+H-H2Of .

The synthetic route of 31108-57-3 has been constantly updated, and we look forward to future research findings.

Some common heterocyclic compound, 31108-57-3, name is 1H-Pyrazole-4-carbonitrile, molecular formula is C4H3N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 1H-Pyrazole-4-carbonitrile

To a solution of I-R15 (200 mg) in anhydrous THF (20 mL) was added lH-pyrazole-4- carbonitrile (90.9 mg, 1.0 mmol) and K2C03 (134 mg, 1.0 mmol) at 25C under N2. The mixture was stirred at 65C for 12 h. The reaction mixture was poured into ice-water (30 mL). The aqueous phase was extracted with EtOAc (2 x 50 mL). The combined organic phase was washed with saturated brine (2 x 50 mL), dried over anhydrous Na2S04, filtered and concentrated. The residue was purified by flash column (30-40% of EtOAc in PE) to give I-R16 (130 mg, 63%) as an oil. (2182) 1H NMR (400 MHz, CDCl3) dH 7.88 (s, 1H), 7.82 (s, 1H), 6.65 (s, 1H), 5.39-5.30 (m, 2H), 2.43 (dd, J= 6.0, 18.4 Hz, 1H), 2.16-2.07 (m, 1H), 2.00 (s, 1H), 1.97-1.49 (m, 7H), 1.43-0.99 (m, 17H), 0.96 (s, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 31108-57-3, its application will become more common.

Application of 31108-57-3, A common heterocyclic compound, 31108-57-3, name is 1H-Pyrazole-4-carbonitrile, molecular formula is C4H3N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a mixture of VI (150 mg, 0.351 mmol) and K2C03 (96.9 mg, 0.702 mmol) in acetone (5 mL) was added lH-pyrazole-4-carbonitrile (48.9 mg, 0.526 mmol) at 25C. The reaction mixture was stirred at the 25C for 16 h. The reaction mixture was quenched by water (20 mL) and extracted with EtOAc (2 x 20 mL). The combined organic layer was dried over Na2SC>4, filtered and concentrated in vacuum to give crude product (50 mg) which was triturated with MeCN (5 mL) to give Compound 47 (41 mg, 27%) as a solid. (0758) 1H NMR (400MHz, DMSO-d6) delta 8.31 (s, 1H), 8.05 (s, 1H), 5.87 (d, J= 18.2 Hz, 1H), 5.22 (d, J= 18.2 Hz, 1H), 4.92-4.88 (m, 1H), 3.88 (s, 1H), 3.56-3.49 (m, 1H), 2.86-2.76 (m, 1H), 1.96- 1.92 (m, 1H), 1.73-1.58 (m, 4H), 1.57-1.44 (m, 1H), 1.42-1.22 (m, 7H), 1.19-1.11 (m, 5H), 1.07 (s, 3H), 0.92-0.77 (m, 2H), 0.70 (s, 3H), 0.54 (s, 3H) LCMS Rt = 0.980 min in 2 min chromatography, 30-90 AB, purity 100%, MS ESI calcd. For C26H37N303Na+ [M+Na]+ 462, found 462.

The synthetic route of 31108-57-3 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 31108-57-3, These common heterocyclic compound, 31108-57-3, name is 1H-Pyrazole-4-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2-chloro-5-nitrobenzenesulfonamide (250 mg, 1.06 mmol) was dissolved in acetonitrile5 (10 mL), followed by addition of 1H-pyrazole-4-carbonitrile (148 mg, 1.59 mmol) and finely powdered potassium carbonate (438 mg, 3.17 mmol). The reaction mixture was stirred overnight at 10000. After cooling to room temperature dichloromethane and water were added and the organic phase was washed with brine solution, dried over sodium sulfate and concentrated in vacuo. Purification by preparative HPLC (Chromatorex 0-18 10pm,10 125x30mm, acetonitrile/water + 0.1% formic acid) gave the title compound (128 mg, 0.436 mmol, 41 % yield, 70 % purity).LC-MS (Method A): Rt = 0.78 mm; MS (ESIpos): mlz = 294 [M+H]1HNMR (400MHz, DMSO-d6) oe [ppm]: 7.94 (br d, 2H), 7.98 (d, 1 H), 8.42 (d, 1 H), 8.61 (dd,1H), 8.83 (d, 1H), 9.04 (d, 1H).

Statistics shows that 1H-Pyrazole-4-carbonitrile is playing an increasingly important role. we look forward to future research findings about 31108-57-3.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 31108-57-3, name is 1H-Pyrazole-4-carbonitrile, A new synthetic method of this compound is introduced below., Application In Synthesis of 1H-Pyrazole-4-carbonitrile

To a suspension of TEA (35.2 mg, 0.348 mmol) and lH-pyrazole-4-carbon (12.9 mg, 0.139 mmol) in DMF (5 mL) was added Jl (50 mg, 0.116 mmol) at 25C under N2. The mixture was stirred at 25C for 16 h. The mixture was concentrated to give a light yellow soild. The solid was purified by pre-HPLC (Column:YMC-Actus Triart CI 8 100*30mm*5um; Condition: water(0.05%HCl)-ACN; Gradient 53%-83%B; Gradient Time(min):9.5) to afford Compound 26 (22 mg, 43% ) as a solid. *H NMR (400 MHz, CDC13) delta 7.85 (s, 1H), 7.81 (s, 1H), 5.05-4.87 (m, 2H), 3.88-3.82 (m, 1H), 2.70-2.58 (m, 1H), 2.28-2.15 (m, 1H), 2.05-1.56 (m, 7H), 1.48-1.15 (m, 17H), 0.76 (s, 3H), 0.66 (s, 3H). (0615) LCMS Rt = 0.828 min in 1.5 min chromatography, 5-95 AB, purity 100 %, MS ESI calcd. for C26H34N3O [M+H-2H20]+ 404, found 404.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.