Category: 2033-45-6

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2033-45-6, name is 3,5-Dimethyl-4-iodopyrazole, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 3,5-Dimethyl-4-iodopyrazole

To a solution of 3,5-Dimethyl-4-iodo-1 H-pyrazole (1 .69g, 7.61 mmol) in DCM (25ml_) was added 3,4- Dihydro-2H-pyran (1 .04mL, 1 1 .4mmol) and pyridinium p-toluenesulfonate (383mg, 1 .52mmol). The reaction was stirred at 40C overnight and then for for 4 days at room temperature. The mixture was diluted with DCM (50ml), washed with sat NaHC03 aq (50ml), dried over Na2S04, filtered and concentrated in vacuo. The residue was purified by flash column chromatography (40g Si02, 0-30% EtOAc in heptane) to provide 4-iodo-3,5-dimethyl-1 -tetrahydropyran-2-yl-pyrazole (2.36g,7.7mmol, 101 .19% yield) as a white solid. MS Method 2: RT: 1 .78 min, ES+ m/z 307.0 [M+H]+ H NMR (400MHz, CDCI3) delta/ppm: 5.23-5.26 (d, J=10.4Hz, 1 H), 4.05-4.08 (m, 1 H), 3.62-3.69 (m, 1 H), 2.39-2.49 (m, 1 H), 2.35 (s, 3H), 2.25 (s, 3H), 2.09-2.14 (m, 1 H). 1 .88-1 .94 (m, 1 H), 1 .64-1 .79 (m, 3H).

According to the analysis of related databases, 2033-45-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; REDX PHARMA PLC; BHAMRA, Inder; BINGHAM, Matilda; TESTAR, Richard; SARGENT, Louise; DONOGHUE, Craig; (128 pag.)WO2016/55786; (2016); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Reference of 2033-45-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2033-45-6, name is 3,5-Dimethyl-4-iodopyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A solution of 1.85g (0.01mol) of 2,4,6-trichloro-1,3,5-triazine in the 50mL THF was stirred at room temperature for 1h. Then, 3,5-dimethylpyrazole (2.94g, 0.03mmol) were added into the solution in batches. 5mL of triethylamine was added dropwise whilst stirring at room temperature. After 1h, the mixture was heated at 80C for 1h. After cooling and filtering off, the filtrate evaporated on a steam bath and then washed with hot-water.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Dimethyl-4-iodopyrazole, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Wang, Ji-Xiao; Zhu, Zi-Ran; Bai, Feng-Ying; Wang, Xin-Yu; Zhang, Xiao-Xi; Xing, Yong-Heng; Polyhedron; vol. 99; (2015); p. 59 – 70;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Reference of 2033-45-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2033-45-6, name is 3,5-Dimethyl-4-iodopyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A solution of pyrazole (2.04g, 0.03mol) in freshly distilled THF (20mL) was added to a stirred suspension of sodium hydride (60%, 2.04g, 0.03mol) in 20mL THF at room temperature. After 1h, Cyanuric chloride (1.85g, 0.01mol) in THF (15mL) was added to the above solution and white precipitate was formed. After being stirred and heating at 70C for 5h, the solution was filtered off, the filtrate evaporated on a steam bath, and then washed with hot-water. 2,4,6-tri(1H-pyrazol-1-yl)methyl)-1,3,5-triazine.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Dimethyl-4-iodopyrazole, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Wang, Ji-Xiao; Zhu, Zi-Ran; Bai, Feng-Ying; Wang, Xin-Yu; Zhang, Xiao-Xi; Xing, Yong-Heng; Polyhedron; vol. 99; (2015); p. 59 – 70;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 2033-45-6, name is 3,5-Dimethyl-4-iodopyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2033-45-6, Product Details of 2033-45-6

In a 50 ml reaction vessel under argon, a solution of crude 4-iodo-3,5-dimethyl-1 H- pyrazole x52 (1.15 g, 5.2 mmol) in 25 ml of dry CH2CI2 is added to 4- methylbenzenesulfonyl chloride (1.18 g, 6.2 mmol). Pyridine (0.42 ml, 5.2 mmol) is added EPO and the mixture is stirred for 16 h at room temperature. The organic phase is washed with water, dried over MgSOphi filtered and concentrated. The residue is purified by column chromatography on silicagel (Ch^C^/hexane: 70/30 (v/v)) to afford 4-iodo-3,5-dimethyl-1- [(4-methylphenyl)sulfonyl]-1H-pyrazole x53 (1.44 g).Yield : 74 %.LC-MS (MH+): 377.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Dimethyl-4-iodopyrazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; UCB S.A.; WO2006/128692; (2006); A2;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthetic Route of 2033-45-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2033-45-6, name is 3,5-Dimethyl-4-iodopyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a solution of 79 (3OOg, 135 immol) in 100 mL of degassed TI-IF was added successively Cul(257mg, i.35mmoi), 2 (2.65g, 27O2mmoi), Pd(PPh3)2C12 (948mg, i.35mmol) and Et3N (410g.40.54rnmol). The mixture was stirred at 80 C for 18 hours. LCM showed that the reaction was completed. The reaction mixture was filtered and the filtrate was concentrated and purified by chrornatograph column to give the product 80 (2.2 g, yield 85%).LCMS: in/z 193 (M+H)t

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Dimethyl-4-iodopyrazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; HUA MEDICINE (SHANGHAI) LTD.; CHEN, Li; JIN, Xiaowei; (176 pag.)WO2017/117708; (2017); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthetic Route of 2033-45-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2033-45-6 name is 3,5-Dimethyl-4-iodopyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(b) 4-iodo–3,5-dimethyl- I -tosyl- 1 H-pyrazole: Triethylamine (1 2.73g, 126. 8nunol) was added toa solution of 4-iodo-3,5-dimeihyl-1H-pyrazole (141)7g. 63.4nimol) in DCM (250 mL), followed byaddition of TsC1 (13.3g 69,7minoi). The mixture was then stirred overnight. After completionof the reaction, water (100 mL) was added and the mixture was extracted with EtOAc (3x80m1). The orgamie solvent was collected and removed under reduced pressure, the residue was purified by silica gel-column to obtaine 4-iodo-3,5-dhnethyl-1-tosyl-IH-pyrazoie (8.0g. yield 33.6%) as a white solid ,LCMS (022): 222.7 [M+H]t Rt :1.65 mm

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3,5-Dimethyl-4-iodopyrazole, and friends who are interested can also refer to it.

Related Products of 2033-45-6, A common heterocyclic compound, 2033-45-6, name is 3,5-Dimethyl-4-iodopyrazole, molecular formula is C5H7IN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1-(1,4-Dioxaspiro[4.5]dec-8-yl)-4-iodo-3,5-dimethyl-1H-pyrazole To a solution of 3,5-dimethyl-4-iodopyrazole (400.0 mg, 1.802 mmol) in DMF (7 mL, 100 mmol) was added sodium hydride (56.20 mg, 2.342 mmol), and the mixture was stirred at rt for 10 min. A solution of 1,4-dioxaspiro[4.5]dec-8-yl 4-methylbenzenesulfonate (619.1 mg, 1.982 mmol), prepared according to U.S. Pat. No. 4,360,531 example 1.B, in DMF was added, and the mixture was heated to 50 C. overnight. The material was extracted with EtOAc, and washed with water (3*). The organic layer was dry-loaded onto silica gel for column chromatography, eluting with 20-30% EtOAc/hexanes. The fractions containing the pure product were concentrated in vacuo to afford the title compound as a clear oil. 1H NMR (400 MHz, DMSO-d6): delta=1.61-1.80 (m, 6H), 1.94-2.06 (m, 2H), 2.08 (s, 3H), 2.25 (s, 3H), 3.82-3.93 (m, 4H), 4.23 (tt, J=11.5, 3.7 Hz, 1H). MS (ES+): m/z=364.07 (100) [MH+]. HPLC: tR=1.51 min (polar-3 min, HPLC-ACQUITY).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2033-45-6, name is 3,5-Dimethyl-4-iodopyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 3,5-Dimethyl-4-iodopyrazole

To a stirred degassed solution of 4-iodo-3,5-dimethyl-1 H-pyrazole (500 mg, 2.25 mmol) in DMF (5 mL) was added Zn(CN)2 (141 .2 mg, 1 .58 mmol) followed by Pd(dppf)CI2 (82.4 mg, 0.1 1 mmol) and Zn-dust (7.4 mg, 0.1 1 mmol) under inert atmosphere. Resulting mixture was heated at 100C for 4 hours. After completion, the reaction mixture was diluted with cold water and extracted with ethyl acetate. Combined organic layer was washed with water, brine, dried over sodium sulphate, filtered, and concentrated under reduced pressure. Crude compound was purified by column chromatography (30%-50% ethyl acetate-hexane) to afford 3,5-dimethyl-1 H- pyrazole-4-carbonitrile (120 mg, 44%) as light brown solid.

The synthetic route of 2033-45-6 has been constantly updated, and we look forward to future research findings.