Category: 5334-28-1

Application of 5334-28-1,Some common heterocyclic compound, 5334-28-1, name is 5-Amino-1-(4-bromophenyl)-1H-pyrazole-4-carbonitrile, molecular formula is C10H7BrN4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1.4: 5-Amino-1-(4-bromo-phenyl)-1H-pyrazole-4-carboxylic acid amide5-Amino-1-(4-bromo-phenyl)-1 H-pyrazole-4-carbonitrile (18.3 g, 69.8 mmol) is slowly added to 93 ml concentrated sulfuric acid (1680 mmol) to keep the temperature between 10-15 C. After the complete addition of the starting material, the reaction mixture is stirred for one hour. Afterwards, the mixture is poured on ice/water and the pH is adjusted to pH 8. The formed precipitate is isolated by filtration and is dried at the high vacuum pump, yielding the title compound. HPLC: tR = 7.91 min; MS-ES+: (M+H)+ = 282

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Amino-1-(4-bromophenyl)-1H-pyrazole-4-carbonitrile, its application will become more common.

Related Products of 5334-28-1,Some common heterocyclic compound, 5334-28-1, name is 5-Amino-1-(4-bromophenyl)-1H-pyrazole-4-carbonitrile, molecular formula is C10H7BrN4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A suspension of the appropriate derivatives 2a-d or 9(0.001 mol) was dissolved in glacial acetic acid (3 mL) then POCl3(0.2 mL) was added quickly. The reaction mixture was refluxedfor 2 h (the reaction system was carefully observed by TLC). Aftercooling the mixture, ice-water was added and the formed precipitatewas filtered, washed with water, dried and recrystallized fromformic acid to give compounds 3e-h or 10b

The synthetic route of 5334-28-1 has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5334-28-1 as follows. Recommanded Product: 5-Amino-1-(4-bromophenyl)-1H-pyrazole-4-carbonitrile

General procedure: A suspension of the appropriate intermediates 2a-d or 9(0.01 mol) in 85% formic acid (40 mL) was heated under refluxfor 10 h. The reaction mixture was cooled and the separated precipitatewas filtered, washed with water, dried and recrystallizedfrom formic acid to afford desired compounds 3a-d or 10a

According to the analysis of related databases, 5334-28-1, the application of this compound in the production field has become more and more popular.

Application of 5334-28-1,Some common heterocyclic compound, 5334-28-1, name is 5-Amino-1-(4-bromophenyl)-1H-pyrazole-4-carbonitrile, molecular formula is C10H7BrN4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: 5-amino-1-aryl-1H-pyrazole-4-carbonitriles 4(aei) (0.001 mol),2.0 mL of 1,2-diaminoethane (ethylenediamine) and carbon disulfide(0.004 mol) were added into a 50 mL round-bottom flaskadapted with a glass condenser. The mixture was kept at 110-115oCfor 12-14 hours. After that, the productwas poured into cold water,the precipitate was filtered out and washed with cold water. Thereactions were accompanied by means of TLC and dichloromethaneas eluent.

The synthetic route of 5334-28-1 has been constantly updated, and we look forward to future research findings.