Category: 119022-51-4

These common heterocyclic compound, 119022-51-4, name is 1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3(2H)-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3(2H)-one

Step 1 : Synthesis of 4-bromo-l-methyl-5-(trifluoromethyl)-2,3-dihydro-lH-pyrazol- 3-one: [01064] To a stirred solution of l-methyl-5-(trifluoromethyl)-lH-pyrazol-3-ol (2g, 12.0 mmol) in ethanol (15 mL) was added bromine (0.74 mL, 14.5 mmol). The resulting solution was stirred at room temperature overnight. After which time, the reaction was concentrated in vacuo and the residue was basified (pH 8) with a saturated aqueous solution of sodium hydrogen carbonate (20 mL). The product was extracted with DCM (5×15 mL) and the combined organics were washed with brine (20 mL). The aqueous phase was back-extracted with DCM (2×5 mL). The combined organics were dried over MgS04, filtered and concentrated in vacuo to afford the title compound as an off white solid (2.48 g, 83% yield), which was used directly in the next step without purification. LC-MS 99%, 1.69 min (3 minute LC-MS method), m/z=244.80, 246.85, XH NMR (500 MHz, Methanol-d4) delta 3.81 (d, J = 1.1 Hz, 3H).

The synthetic route of 1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3(2H)-one has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 119022-51-4, name is 1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3(2H)-one, A new synthetic method of this compound is introduced below., Safety of 1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3(2H)-one

Example 2: Preparation of 2-(1 -methyl-5-trifluoromethyl-1 H-pyrazol-3-yloxy)-thiazole- 5-sulfonic acid (2-methoxy-pyridin-4-ylmethyl)-amide (Table I, example I-4) Example 2.1 : Preparation of 2-(1-methyl-5-trifluoromethyl-1 H-pyrazol-3-yloxy)-thiazole 1-Methyl-5-trifluoromethyl-1 H-pyrazol-3-ol (5.1 g) in dry DMF (50 ml) under nitrogen was treated at 00C with sodium hydride (0.82 g). After the initial effervescence ceased 2-bromothiazol (5 g) and Kl (4.4 g) were added. The mixture was stirred for 23 h at1400C, the solvent was removed by rotary evaporation and the residue was purified by flash column chromatography on silica gel (cyclohexan/ethyl acetate) to yield the title compound as yellow oil (4.94 g). 1H-NMR (CDCI3): d= 3.98 (s, 3H), 6.6 (s, 1 H), 6.9 (s, 1 H), 7.3 ppm (s,1 H)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.